Formulary Overlay
BEXSERO (Meningococcal Group B Vaccine) targets 4 distinct antigenic components to help protect against meningitis B strains1,2
BEXSERO induces antibodies to these 4 antigenic components3,*
Contributes to bacterial survival in the blood4,5
Promotes adherence of bacteria to human epithelial cells and invasion into these cells6-8
Major Outer Membrane Vesicle protein has been shown to induce strain-specific bactericidal response9
Contributes to bacterial survival in the blood10
*
The susceptibility of serogroup B meningococci to complement-mediated antibody-dependent killing following vaccination with BEXSERO is dependent on both the antigenic similarity of the bacterial and vaccine antigens, as well as the amount of antigen expressed on the surface of the invading meningococci.3
fHbp=factor H binding protein; NadA=Neisserial adhesin A; NHBA=Neisserial Heparin Binding Antigen; PorA=Porin A P1.4 present in Outer Membrane Vesicles (OMV).