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welcome<00:00:09.269><c> to</c><00:00:09.480><c> the</c><00:00:09.570><c> daily</c><c.colorE5E5E5><00:00:09.719><c> highlights</c><00:00:09.929><c> videos</c></c>

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welcome to the daily<c.colorE5E5E5> highlights videos
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welcome to the daily<c.colorE5E5E5> highlights videos
from<00:00:10.740><c> the</c><00:00:10.950><c> ers</c></c><c.colorCCCCCC><00:00:11.519><c> my</c><00:00:12.240><c> name</c><00:00:12.389><c> is</c><00:00:12.509><c> Neil</c><00:00:12.660><c> Martin</c><00:00:12.900><c> I'm</c></c>

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from the ers<c.colorCCCCCC> my name is Neil Martin I'm
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from the ers<c.colorCCCCCC> my name is Neil Martin I'm
one<00:00:13.380><c> of</c><00:00:13.500><c> the</c><00:00:13.620><c> global</c></c><c.colorE5E5E5><00:00:13.889><c> medical</c><00:00:14.280><c> experts</c><00:00:14.759><c> who</c></c>

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one of the global<c.colorE5E5E5> medical experts who
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one of the global<c.colorE5E5E5> medical experts who
works<00:00:15.150><c> for</c><00:00:15.330><c> GSK</c><00:00:15.780><c> and</c></c><c.colorCCCCCC><00:00:16.049><c> I'm</c><00:00:16.470><c> joined</c><00:00:16.740><c> by</c><00:00:17.130><c> today</c></c>

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works for GSK<c.colorE5E5E5> and</c><c.colorCCCCCC> I'm joined by today
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works for GSK<c.colorE5E5E5> and</c><c.colorCCCCCC> I'm joined by today
but<00:00:18.300><c> with</c><00:00:18.449><c> my</c><00:00:18.570><c> colleague</c></c><c.colorE5E5E5><00:00:18.900><c> Emilio</c><00:00:19.380><c> please</c></c>

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but with my colleague<c.colorE5E5E5> Emilio please
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but with my colleague<c.colorE5E5E5> Emilio please</c>
<c.colorCCCCCC>zucchini</c><c.colorE5E5E5><00:00:19.920><c> one</c><00:00:20.400><c> of</c><00:00:20.490><c> our</c></c><c.colorCCCCCC><00:00:20.609><c> Jimmy's</c><00:00:21.029><c> from</c><00:00:21.330><c> Brazil</c></c>

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<c.colorCCCCCC>zucchini</c><c.colorE5E5E5> one of our</c><c.colorCCCCCC> Jimmy's from Brazil
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<c.colorCCCCCC>zucchini</c><c.colorE5E5E5> one of our</c><c.colorCCCCCC> Jimmy's from Brazil</c>
<c.colorE5E5E5>we<00:00:23.010><c> both</c><00:00:23.189><c> went</c><00:00:23.400><c> to</c><00:00:23.730><c> a</c><00:00:24.029><c> lunchtime</c><00:00:24.390><c> session</c></c>

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<c.colorE5E5E5>we both went to a lunchtime session
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<c.colorE5E5E5>we both went to a lunchtime session
today<00:00:25.140><c> which</c><00:00:25.470><c> was</c><00:00:25.650><c> run</c><00:00:25.890><c> based</c><00:00:26.640><c> around</c><00:00:26.880><c> new</c></c>

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today<c.colorE5E5E5> which was run based around new
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today<c.colorE5E5E5> which was run based around new
biologic<00:00:27.840><c> agents</c><00:00:28.320><c> for</c><00:00:28.560><c> severe</c><00:00:28.830><c> asthma</c></c>

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biologic agents for severe asthma
 

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biologic agents for severe asthma
<c.colorE5E5E5>I<00:00:29.580><c> mean</c></c><c.colorCCCCCC><00:00:30.330><c> though</c><00:00:30.449><c> there</c><00:00:30.570><c> was</c><00:00:30.660><c> a</c><00:00:30.689><c> lot</c></c><c.colorE5E5E5><00:00:30.750><c> of</c></c>

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<c.colorE5E5E5>I mean</c><c.colorCCCCCC> though there was a lot</c><c.colorE5E5E5> of
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<c.colorE5E5E5>I mean</c><c.colorCCCCCC> though there was a lot</c><c.colorE5E5E5> of
discussion<00:00:31.590><c> and</c><00:00:31.769><c> the</c><00:00:32.239><c> seminar</c><00:00:33.239><c> today</c></c>

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discussion<c.colorE5E5E5> and the seminar today
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discussion<c.colorE5E5E5> and the seminar today
starting<00:00:34.530><c> with</c><00:00:34.559><c> Sally</c><00:00:35.190><c> Wenzel</c><00:00:35.640><c> who</c><00:00:36.390><c> went</c></c>

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starting with<c.colorE5E5E5> Sally Wenzel who went
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starting with<c.colorE5E5E5> Sally Wenzel who went
through</c><c.colorCCCCCC><00:00:36.719><c> then</c><00:00:37.079><c> an</c><00:00:37.230><c> overview</c><00:00:37.649><c> of</c><00:00:37.739><c> the</c><00:00:37.860><c> biology</c></c>

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through<c.colorCCCCCC> then an overview of the biology
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through<c.colorCCCCCC> then an overview of the biology
of<00:00:38.430><c> all</c><00:00:38.700><c> the</c><00:00:38.820><c> different</c><00:00:39.090><c> biologic</c><00:00:39.570><c> agents</c><00:00:39.960><c> and</c></c>

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of all the different biologic agents and
 

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of all the different biologic agents and
one<00:00:40.770><c> of</c><00:00:40.829><c> the</c><00:00:40.890><c> things</c><00:00:41.010><c> that</c><c.colorE5E5E5><00:00:41.100><c> really</c><00:00:41.160><c> stood</c><00:00:41.550><c> out</c></c>

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one of the things that<c.colorE5E5E5> really stood out
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one of the things that<c.colorE5E5E5> really stood out</c>
<c.colorCCCCCC>to<00:00:41.879><c> me</c><00:00:41.910><c> was</c><00:00:42.210><c> the</c></c><c.colorE5E5E5><00:00:42.239><c> importance</c><00:00:43.050><c> of</c><00:00:43.170><c> the</c><00:00:43.680><c> presence</c></c>

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<c.colorCCCCCC>to me was the</c><c.colorE5E5E5> importance of the presence
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<c.colorCCCCCC>to me was the</c><c.colorE5E5E5> importance of the presence
or<00:00:44.309><c> absence</c><00:00:44.489><c> of</c></c><c.colorCCCCCC><00:00:44.879><c> ES</c></c><c.colorE5E5E5><00:00:45.180><c> and</c></c><c.colorCCCCCC><00:00:45.239><c> a</c></c><c.colorE5E5E5><00:00:45.390><c> filling</c></c>

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or<c.colorE5E5E5> absence of</c><c.colorCCCCCC> ES</c><c.colorE5E5E5> and</c><c.colorCCCCCC> a</c><c.colorE5E5E5> filling
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or<c.colorE5E5E5> absence of</c><c.colorCCCCCC> ES</c><c.colorE5E5E5> and</c><c.colorCCCCCC> a</c><c.colorE5E5E5> filling
inflammation<00:00:46.320><c> in</c><00:00:46.980><c> severe</c><00:00:47.789><c> asthma</c></c><c.colorCCCCCC><00:00:48.210><c> what</c><00:00:48.870><c> was</c></c>

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inflammation in severe asthma<c.colorCCCCCC> what was
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inflammation in severe asthma<c.colorCCCCCC> what was
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your take on that well<c.colorCCCCCC> I think sister
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your take on that well<c.colorCCCCCC> I think sister
the<00:00:53.520><c> research</c><00:00:54.149><c> that</c></c><c.colorE5E5E5><00:00:54.180><c> start</c><00:00:54.809><c> with</c></c>

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the research that<c.colorE5E5E5> start with
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the research that<c.colorE5E5E5> start with
bronchoscopy</c><c.colorCCCCCC><00:00:55.829><c> and</c><00:00:56.670><c> this</c><00:00:57.300><c> has</c><00:00:57.539><c> been</c></c>

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bronchoscopy<c.colorCCCCCC> and this has been
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bronchoscopy<c.colorCCCCCC> and this has been</c>
<c.colorE5E5E5>highlighted</c><c.colorCCCCCC><00:00:58.440><c> in</c><00:00:59.039><c> the</c><00:00:59.190><c> meeting</c><00:00:59.520><c> that</c></c><c.colorE5E5E5><00:00:59.730><c> we</c></c>

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<c.colorE5E5E5>highlighted</c><c.colorCCCCCC> in the meeting that</c><c.colorE5E5E5> we
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<c.colorE5E5E5>highlighted</c><c.colorCCCCCC> in the meeting that</c><c.colorE5E5E5> we
understood<00:01:01.320><c> that</c><00:01:01.579><c> asthma</c><00:01:02.579><c> is</c><00:01:03.019><c> heterogeneous</c></c>

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understood that<c.colorE5E5E5> asthma is heterogeneous
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understood that<c.colorE5E5E5> asthma is heterogeneous
disease<00:01:04.400><c> some</c><00:01:05.400><c> patients</c><00:01:05.909><c> have</c><00:01:06.060><c> asthma</c><00:01:06.810><c> that</c></c>

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<c.colorE5E5E5>disease some patients have asthma that
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<c.colorE5E5E5>disease some patients have asthma that
is<00:01:07.439><c> rich</c><00:01:07.740><c> in</c><00:01:08.040><c> the</c><00:01:08.250><c> original</c></c><c.colorCCCCCC><00:01:08.549><c> field</c></c><c.colorE5E5E5><00:01:08.820><c> aged</c><00:01:09.299><c> too</c></c>

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<c.colorE5E5E5>is rich in the original</c><c.colorCCCCCC> field</c><c.colorE5E5E5> aged too
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<c.colorE5E5E5>is rich in the original</c><c.colorCCCCCC> field</c><c.colorE5E5E5> aged too
high<00:01:10.439><c> and</c><00:01:10.770><c> some</c><00:01:11.430><c> patients</c><00:01:11.820><c> have</c><00:01:11.939><c> an</c><00:01:12.180><c> asthma</c></c>

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high<c.colorE5E5E5> and some patients have an asthma
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high<c.colorE5E5E5> and some patients have an asthma</c>
<c.colorCCCCCC>that<00:01:12.750><c> does</c><00:01:13.080><c> not</c><00:01:13.320><c> have</c><00:01:13.619><c> the</c><00:01:13.860><c> zeal</c><00:01:14.070><c> of</c><00:01:14.159><c> yours</c></c>

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<c.colorCCCCCC>that does not have the zeal of yours
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<c.colorCCCCCC>that does not have the zeal of yours
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what you have<c.colorE5E5E5> understood also</c><c.colorCCCCCC> that there
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what you have<c.colorE5E5E5> understood also</c><c.colorCCCCCC> that there
are</c><c.colorE5E5E5><00:01:18.030><c> critical</c></c><c.colorCCCCCC><00:01:18.479><c> characters</c><00:01:18.990><c> that</c><00:01:19.320><c> may</c></c>

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are<c.colorE5E5E5> critical</c><c.colorCCCCCC> characters that may
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are<c.colorE5E5E5> critical</c><c.colorCCCCCC> characters that may
differentiate</c><c.colorE5E5E5><00:01:20.070><c> those</c><00:01:20.580><c> in</c><00:01:20.759><c> the</c><00:01:20.850><c> physical</c></c>

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differentiate<c.colorE5E5E5> those in the physical
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differentiate<c.colorE5E5E5> those in the physical</c>
<c.colorCCCCCC>model<00:01:21.600><c> to</c></c><c.colorE5E5E5><00:01:21.780><c> the</c></c><c.colorCCCCCC><00:01:21.900><c> FIDIC</c><00:01:22.170><c> asthma</c></c><c.colorE5E5E5><00:01:22.590><c> but</c><00:01:23.040><c> mostly</c><00:01:23.780><c> we</c></c>

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<c.colorCCCCCC>model to</c><c.colorE5E5E5> the</c><c.colorCCCCCC> FIDIC asthma</c><c.colorE5E5E5> but mostly we
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<c.colorCCCCCC>model to</c><c.colorE5E5E5> the</c><c.colorCCCCCC> FIDIC asthma</c><c.colorE5E5E5> but mostly we
need<00:01:25.020><c> to</c><00:01:25.140><c> use</c><00:01:25.350><c> a</c><00:01:25.380><c> biomarker</c><00:01:25.979><c> to</c><00:01:26.340><c> predict</c><00:01:26.759><c> to</c></c>

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need to use a biomarker to predict<c.colorE5E5E5> to
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need to use a biomarker to predict<c.colorE5E5E5> to
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understand what kind of asthma those
 

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understand what kind of asthma those
patients<00:01:30.900><c> have</c><00:01:31.310><c> the</c><00:01:32.310><c> biomarkers</c><c.colorCCCCCC><00:01:33.270><c> that</c><00:01:33.450><c> have</c></c>

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patients have the biomarkers<c.colorCCCCCC> that have
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patients have the biomarkers<c.colorCCCCCC> that have
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been spoken about where you know<c.colorCCCCCC> fuse
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been spoken about where you know<c.colorCCCCCC> fuse</c>
<c.colorE5E5E5>fuse<00:01:36.450><c> oh</c></c><c.colorCCCCCC><00:01:36.659><c> and</c><00:01:36.900><c> blood</c><00:01:37.340><c> Perry</c><00:01:38.340><c> Austin</c></c><c.colorE5E5E5><00:01:38.820><c> and</c></c>

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<c.colorE5E5E5>fuse oh</c><c.colorCCCCCC> and blood Perry Austin</c><c.colorE5E5E5> and
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<c.colorE5E5E5>fuse oh</c><c.colorCCCCCC> and blood Perry Austin</c><c.colorE5E5E5> and
phenyl<00:01:40.490><c> and</c></c><c.colorCCCCCC><00:01:41.490><c> so</c><00:01:42.270><c> Elizabeth</c></c><c.colorE5E5E5><00:01:42.630><c> Bell</c><00:01:42.810><c> then</c><00:01:43.020><c> gave</c></c>

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phenyl and<c.colorCCCCCC> so Elizabeth</c><c.colorE5E5E5> Bell then gave
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phenyl and<c.colorCCCCCC> so Elizabeth</c><c.colorE5E5E5> Bell then gave
the<00:01:43.380><c> second</c></c><c.colorCCCCCC><00:01:43.799><c> table</c></c><c.colorE5E5E5><00:01:44.009><c> looking</c><00:01:44.820><c> at</c><00:01:45.000><c> the</c></c>

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the second<c.colorCCCCCC> table</c><c.colorE5E5E5> looking at the
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the second<c.colorCCCCCC> table</c><c.colorE5E5E5> looking at the
translational<00:01:46.020><c> science</c><00:01:46.560><c> so</c><00:01:47.280><c> we</c><00:01:47.399><c> have</c><00:01:47.520><c> this</c></c>

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translational science<c.colorE5E5E5> so we have this
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translational science<c.colorE5E5E5> so we have this
range<00:01:47.970><c> of</c><00:01:48.270><c> biomarkers</c><00:01:48.990><c> which</c><00:01:49.200><c> indicate</c></c><c.colorCCCCCC><00:01:50.009><c> th2</c></c>

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<c.colorE5E5E5>range of biomarkers which indicate</c><c.colorCCCCCC> th2
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<c.colorE5E5E5>range of biomarkers which indicate</c><c.colorCCCCCC> th2
high<00:01:50.700><c> disease</c><00:01:51.030><c> as</c><00:01:51.180><c> you</c></c><c.colorE5E5E5><00:01:51.210><c> say</c><00:01:51.479><c> but</c><00:01:52.229><c> it</c><00:01:52.320><c> was</c><00:01:52.470><c> clear</c></c>

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high disease as you<c.colorE5E5E5> say but it was clear
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high disease as you<c.colorE5E5E5> say but it was clear
that<00:01:52.799><c> the</c><00:01:53.250><c> presence</c><00:01:54.060><c> or</c><00:01:54.149><c> absence</c><00:01:54.299><c> of</c><00:01:54.810><c> a</c><00:01:55.170><c> high</c></c>

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that the presence or absence of<c.colorE5E5E5> a high
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that the presence or absence of<c.colorE5E5E5> a high
blood<00:01:55.829><c> is</c></c><c.colorCCCCCC><00:01:56.100><c> of</c></c><c.colorE5E5E5><00:01:56.369><c> a</c><00:01:56.490><c> kind</c></c><c.colorCCCCCC><00:01:56.729><c> seemed</c><00:01:57.450><c> to</c><00:01:57.659><c> determine</c></c>

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blood is<c.colorCCCCCC> of</c><c.colorE5E5E5> a kind</c><c.colorCCCCCC> seemed to determine
 </c>

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blood is<c.colorCCCCCC> of</c><c.colorE5E5E5> a kind</c><c.colorCCCCCC> seemed to determine
response<00:01:58.409><c> to</c><00:01:58.560><c> therapy</c><00:01:58.710><c> in</c><00:01:58.920><c> other</c><00:01:59.009><c> words</c><00:01:59.159><c> it</c></c>

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response to therapy in other words it
 

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response to therapy in other words it
was<00:01:59.430><c> a</c><00:01:59.460><c> predictive</c><00:02:00.090><c> biomarker</c><00:02:00.810><c> for</c><c.colorCCCCCC><00:02:00.990><c> these</c></c>

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was a predictive biomarker for<c.colorCCCCCC> these
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was a predictive biomarker for<c.colorCCCCCC> these
patients<00:02:01.619><c> responding</c><00:02:02.250><c> to</c><00:02:02.340><c> biologics</c><00:02:03.049><c> yet</c></c>

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patients responding to biologics yet
 

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patients responding to biologics yet
understand<00:02:04.710><c> the</c><c.colorE5E5E5><00:02:04.770><c> road</c><00:02:05.040><c> about</c><00:02:05.369><c> civilians</c><00:02:05.880><c> in</c></c>

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understand the<c.colorE5E5E5> road about civilians in
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understand the<c.colorE5E5E5> road about civilians in
the<00:02:06.119><c> field</c></c><c.colorCCCCCC><00:02:06.299><c> chiasma</c></c><c.colorE5E5E5><00:02:06.780><c> it's</c><00:02:06.960><c> mainly</c><00:02:07.290><c> about</c></c>

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the field<c.colorCCCCCC> chiasma</c><c.colorE5E5E5> it's mainly about
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the field<c.colorCCCCCC> chiasma</c><c.colorE5E5E5> it's mainly about</c>
<c.colorE5E5E5>understanding<00:02:08.429><c> the</c><00:02:08.550><c> role</c><00:02:08.700><c> of</c><00:02:08.729><c> blood</c></c>

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<c.colorE5E5E5>understanding the role of blood
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<c.colorE5E5E5>understanding the role of blood
eosinophils<00:02:09.929><c> our</c><00:02:10.110><c> biomarker</c><00:02:10.890><c> in</c><00:02:11.489><c> the</c></c>

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eosinophils our biomarker in the
 

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eosinophils our biomarker in the
beginning<00:02:11.910><c> that</c><00:02:12.150><c> was</c><00:02:12.360><c> not</c>

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beginning that was not
 

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beginning that was not
the<00:02:13.420><c> road</c><00:02:13.660><c> that</c><00:02:13.870><c> was</c><00:02:14.080><c> choosing</c><c.colorCCCCCC><00:02:14.560><c> foremost</c><00:02:15.070><c> at</c></c>

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the road that was choosing<c.colorCCCCCC> foremost at
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the road that was choosing<c.colorCCCCCC> foremost at
pharmaceutical<00:02:16.060><c> companies</c><00:02:16.480><c> to</c><00:02:16.950><c> understand</c></c>

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pharmaceutical companies<c.colorCCCCCC> to understand
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pharmaceutical companies<c.colorCCCCCC> to understand
that</c><c.colorE5E5E5><00:02:18.160><c> at</c><00:02:18.370><c> the</c><00:02:18.400><c> response</c><00:02:18.910><c> to</c><00:02:19.030><c> treatment</c><00:02:19.480><c> but</c></c>

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that<c.colorE5E5E5> at the response to treatment but
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that<c.colorE5E5E5> at the response to treatment but
later<00:02:20.050><c> on</c><00:02:20.250><c> parasitical</c><00:02:21.250><c> companies</c></c><c.colorCCCCCC><00:02:21.700><c> develop</c></c>

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later on<c.colorE5E5E5> parasitical companies</c><c.colorCCCCCC> develop
 </c>

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later on<c.colorE5E5E5> parasitical companies</c><c.colorCCCCCC> develop
in<00:02:22.750><c> New</c><00:02:22.990><c> England</c><00:02:23.290><c> biological</c><00:02:24.270><c> choose</c><00:02:25.270><c> body</c></c>

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<c.colorCCCCCC>in New England biological choose body
 </c>

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<c.colorCCCCCC>in New England biological choose body
asana<00:02:26.350><c> fuels</c><00:02:26.590><c> has</c></c><c.colorE5E5E5><00:02:27.130><c> been</c><00:02:27.400><c> made</c><00:02:27.640><c> biomarker</c><00:02:28.390><c> to</c></c>

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<c.colorCCCCCC>asana fuels has</c><c.colorE5E5E5> been made biomarker to
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<c.colorCCCCCC>asana fuels has</c><c.colorE5E5E5> been made biomarker to
follow<00:02:28.810><c> those</c><00:02:29.050><c> patients</c><00:02:29.260><c> and</c><00:02:30.040><c> then</c><00:02:30.670><c> it</c></c>

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follow those patients<c.colorE5E5E5> and then it
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follow those patients<c.colorE5E5E5> and then it
becomes<00:02:31.120><c> a</c><00:02:31.390><c> challenge</c><00:02:31.720><c> because</c><00:02:32.110><c> we</c></c><c.colorCCCCCC><00:02:32.350><c> have</c><00:02:33.040><c> one</c></c>

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becomes a challenge<c.colorE5E5E5> because we</c><c.colorCCCCCC> have one
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becomes a challenge<c.colorE5E5E5> because we</c><c.colorCCCCCC> have one
biomarker<00:02:34.090><c> which</c><00:02:35.040><c> predicts</c><00:02:36.040><c> responds</c><00:02:36.490><c> to</c></c>

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biomarker which predicts<c.colorCCCCCC> responds to
 </c>

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biomarker which predicts<c.colorCCCCCC> responds to
many<00:02:36.820><c> different</c><00:02:37.000><c> drugs</c></c><c.colorE5E5E5><00:02:37.390><c> and</c><00:02:37.660><c> roland</c></c><c.colorCCCCCC><00:02:38.080><c> bull</c></c>

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many different<c.colorCCCCCC> drugs</c><c.colorE5E5E5> and roland</c><c.colorCCCCCC> bull
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many different<c.colorCCCCCC> drugs</c><c.colorE5E5E5> and roland</c><c.colorCCCCCC> bull
from</c><c.colorE5E5E5><00:02:38.530><c> germany</c><00:02:38.890><c> then</c><00:02:39.150><c> gave</c><00:02:40.150><c> us</c><00:02:40.270><c> a</c><00:02:40.360><c> little</c></c>

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from<c.colorE5E5E5> germany then gave us a little
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from<c.colorE5E5E5> germany then gave us a little
rundown<00:02:40.750><c> of</c><00:02:41.020><c> how</c><00:02:41.230><c> they</c><00:02:41.470><c> look</c><00:02:41.680><c> in</c><00:02:41.800><c> clinical</c></c>

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rundown<c.colorE5E5E5> of how they look in clinical
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rundown<c.colorE5E5E5> of how they look in clinical
practice</c><c.colorCCCCCC><00:02:42.160><c> to</c></c><c.colorE5E5E5><00:02:42.520><c> try</c><00:02:42.820><c> and</c><00:02:42.940><c> work</c><00:02:43.060><c> out</c><00:02:43.240><c> which</c></c>

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practice<c.colorCCCCCC> to</c><c.colorE5E5E5> try and work out which
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practice<c.colorCCCCCC> to</c><c.colorE5E5E5> try and work out which
patient<00:02:43.960><c> for</c><00:02:44.110><c> which</c><00:02:44.260><c> medicine</c><00:02:44.710><c> and</c><00:02:45.160><c> it</c><00:02:45.550><c> became</c></c>

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patient for which medicine<c.colorE5E5E5> and it became
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patient for which medicine<c.colorE5E5E5> and it became
obvious<00:02:45.940><c> it</c><00:02:46.210><c> was</c><00:02:46.330><c> quite</c><00:02:46.570><c> difficult</c></c><c.colorCCCCCC><00:02:46.810><c> and</c></c><c.colorE5E5E5><00:02:47.380><c> there</c></c>

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obvious it was quite difficult<c.colorCCCCCC> and</c><c.colorE5E5E5> there
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obvious it was quite difficult<c.colorCCCCCC> and</c><c.colorE5E5E5> there
was<00:02:47.620><c> a</c><00:02:47.650><c> call</c><00:02:47.950><c> for</c><00:02:48.280><c> some</c><00:02:48.570><c> way</c></c><c.colorCCCCCC><00:02:49.570><c> forward</c><00:02:50.230><c> of</c><00:02:50.440><c> how</c></c>

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was a call for some way<c.colorCCCCCC> forward of how
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was a call for some way<c.colorCCCCCC> forward of how
we<00:02:50.680><c> do</c><00:02:50.920><c> this</c><00:02:50.950><c> and</c><00:02:51.370><c> pragmatic</c></c><c.colorE5E5E5><00:02:52.060><c> randomized</c></c>

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we do this<c.colorCCCCCC> and pragmatic</c><c.colorE5E5E5> randomized
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we do this<c.colorCCCCCC> and pragmatic</c><c.colorE5E5E5> randomized
controlled<00:02:53.140><c> trials</c><00:02:53.530><c> how</c><00:02:53.650><c> do</c><00:02:53.710><c> you</c><00:02:53.830><c> think</c><00:02:54.040><c> we're</c></c>

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<c.colorE5E5E5>controlled trials how do you think we're
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<c.colorE5E5E5>controlled trials how do you think we're
going<00:02:54.370><c> to</c><00:02:54.460><c> do</c><00:02:54.670><c> this</c><00:02:54.820><c> going</c><00:02:55.060><c> forward</c><00:02:55.360><c> yeah</c><00:02:56.080><c> the</c></c>

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going<c.colorE5E5E5> to do this going forward yeah the
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going<c.colorE5E5E5> to do this going forward yeah the
reason<00:02:56.470><c> for</c><00:02:57.160><c> this</c><00:02:57.340><c> is</c><00:02:57.400><c> we</c><00:02:58.120><c> don't</c></c><c.colorCCCCCC><00:02:58.330><c> have</c><00:02:58.660><c> direct</c></c>

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reason for this is<c.colorE5E5E5> we don't</c><c.colorCCCCCC> have direct
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reason for this is<c.colorE5E5E5> we don't</c><c.colorCCCCCC> have direct
comparison<00:02:59.830><c> between</c><00:02:59.860><c> all</c><00:03:00.790><c> the</c><00:03:01.180><c> treatment</c></c>

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comparison between all the treatment
 

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comparison between all the treatment
drugs<00:03:01.960><c> that</c><00:03:02.170><c> we</c><00:03:02.320><c> have</c><c.colorE5E5E5><00:03:02.350><c> for</c><00:03:02.740><c> severe</c><00:03:03.070><c> asthma</c></c>

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drugs that we have<c.colorE5E5E5> for severe asthma
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drugs that we have<c.colorE5E5E5> for severe asthma</c>
<c.colorE5E5E5>however<00:03:05.110><c> we</c><00:03:05.380><c> have</c><00:03:06.360><c> meta-analysis</c><00:03:07.360><c> and</c><00:03:07.510><c> some</c></c>

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<c.colorE5E5E5>however we have meta-analysis and some
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<c.colorE5E5E5>however we have meta-analysis and some</c>
<c.colorCCCCCC>methanol's</c><c.colorE5E5E5><00:03:08.500><c> have</c><00:03:08.710><c> been</c><00:03:08.890><c> published</c><00:03:09.280><c> in</c><00:03:09.310><c> the</c></c>

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<c.colorCCCCCC>methanol's</c><c.colorE5E5E5> have been published in the
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<c.colorCCCCCC>methanol's</c><c.colorE5E5E5> have been published in the</c>
<c.colorCCCCCC>past</c><c.colorE5E5E5><00:03:09.490><c> the</c></c><c.colorCCCCCC><00:03:09.970><c> cochrane</c><00:03:10.330><c> mainly</c><00:03:10.750><c> showed</c><00:03:11.440><c> that</c></c>

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<c.colorCCCCCC>past</c><c.colorE5E5E5> the</c><c.colorCCCCCC> cochrane mainly showed that
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<c.colorCCCCCC>past</c><c.colorE5E5E5> the</c><c.colorCCCCCC> cochrane mainly showed that
there<00:03:11.890><c> was</c><00:03:12.040><c> no</c><00:03:12.220><c> difference</c><00:03:12.430><c> between</c></c>

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there was no difference<c.colorCCCCCC> between
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there was no difference<c.colorCCCCCC> between
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treatments but they<c.colorCCCCCC> recommend</c><c.colorE5E5E5> in in the
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treatments but they<c.colorCCCCCC> recommend</c><c.colorE5E5E5> in in the
end<00:03:15.280><c> that</c><00:03:16.000><c> a</c><00:03:16.390><c> network</c><00:03:16.990><c> meta</c><00:03:17.230><c> knowledge</c><00:03:17.620><c> could</c></c>

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end<c.colorE5E5E5> that a network meta knowledge could
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end<c.colorE5E5E5> that a network meta knowledge could
give<00:03:18.280><c> us</c><00:03:18.459><c> better</c><00:03:19.120><c> answer</c><00:03:19.810><c> and</c><00:03:20.050><c> it</c><00:03:20.890><c> has</c><00:03:21.130><c> been</c></c>

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give us better answer<c.colorE5E5E5> and it has been
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give us better answer<c.colorE5E5E5> and it has been
published<00:03:21.489><c> during</c><00:03:21.970><c> this</c><00:03:22.239><c> week</c></c><c.colorCCCCCC><00:03:22.510><c> paper</c><00:03:23.230><c> in</c><00:03:23.470><c> de</c></c>

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published<c.colorE5E5E5> during this week</c><c.colorCCCCCC> paper in de
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published<c.colorE5E5E5> during this week</c><c.colorCCCCCC> paper in de
jakke</c>

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jakke
 

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jakke
we're<00:03:24.550><c> a</c><00:03:24.580><c> network</c><c.colorCCCCCC><00:03:25.060><c> metallized</c><00:03:25.930><c> was</c><00:03:26.260><c> perform</c></c>

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we're a network<c.colorCCCCCC> metallized was perform
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we're a network<c.colorCCCCCC> metallized was perform
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<c.colorCCCCCC>at and comparison were made between
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<c.colorCCCCCC>at and comparison were made between
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subjects that they<c.colorCCCCCC> looked</c><c.colorE5E5E5> alike in
 </c>

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subjects that they<c.colorCCCCCC> looked</c><c.colorE5E5E5> alike in</c>
<c.colorCCCCCC>relation<00:03:33.730><c> to</c><00:03:33.760><c> do</c><00:03:34.090><c> synthetic</c></c><c.colorE5E5E5><00:03:34.420><c> inflammation</c><00:03:35.320><c> of</c></c>

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<c.colorCCCCCC>relation to do synthetic</c><c.colorE5E5E5> inflammation of
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<c.colorCCCCCC>relation to do synthetic</c><c.colorE5E5E5> inflammation of
the<00:03:35.680><c> airways</c><00:03:36.340><c> and</c><00:03:36.580><c> the</c><00:03:37.000><c> lack</c><00:03:37.630><c> of</c><00:03:37.660><c> the</c><00:03:38.020><c> control</c></c>

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the airways<c.colorE5E5E5> and the lack of the control
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the airways<c.colorE5E5E5> and the lack of the control</c>
<c.colorE5E5E5>and<00:03:38.950><c> when</c><00:03:39.580><c> we</c><00:03:39.760><c> use</c><00:03:40.000><c> those</c><00:03:40.360><c> elements</c><00:03:41.459><c> we</c><00:03:42.459><c> can</c></c>

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<c.colorE5E5E5>and when we use those elements we can
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<c.colorE5E5E5>and when we use those elements we can
see<00:03:42.910><c> that</c><00:03:43.090><c> response</c><00:03:43.660><c> to</c><00:03:43.840><c> maple</c><00:03:44.140><c> is</c></c><c.colorCCCCCC><00:03:44.260><c> Uma</c><00:03:44.470><c> is</c></c>

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see that<c.colorE5E5E5> response to maple is</c><c.colorCCCCCC> Uma is
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see that<c.colorE5E5E5> response to maple is</c><c.colorCCCCCC> Uma is
better<00:03:45.370><c> for</c><00:03:45.700><c> acceleration</c></c><c.colorE5E5E5><00:03:46.239><c> reduction</c><00:03:46.989><c> in</c></c>

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better for<c.colorCCCCCC> acceleration</c><c.colorE5E5E5> reduction in
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better for<c.colorCCCCCC> acceleration</c><c.colorE5E5E5> reduction in
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relation to the other<c.colorE5E5E5> two components and
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relation to the other<c.colorE5E5E5> two components and
and<00:03:51.280><c> and</c><00:03:51.550><c> you're</c><00:03:52.239><c> obviously</c><00:03:52.360><c> right</c><00:03:52.690><c> so</c><00:03:52.900><c> we</c></c>

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and and you're obviously<c.colorE5E5E5> right so we
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and and you're obviously<c.colorE5E5E5> right so we
have<00:03:53.170><c> this</c><00:03:53.320><c> network</c></c><c.colorCCCCCC><00:03:53.650><c> meta-analysis</c><00:03:54.520><c> but</c><00:03:55.000><c> the</c></c>

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have this<c.colorE5E5E5> network</c><c.colorCCCCCC> meta-analysis but the
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have this<c.colorE5E5E5> network</c><c.colorCCCCCC> meta-analysis but the
call<00:03:55.420><c> and</c><00:03:55.780><c> the</c><00:03:55.870><c> idea</c></c><c.colorE5E5E5><00:03:56.200><c> of</c><00:03:56.260><c> this</c><00:03:56.380><c> symposium</c><00:03:56.709><c> came</c></c>

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call and the idea<c.colorE5E5E5> of this symposium came
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call and the idea<c.colorE5E5E5> of this symposium came
from<00:03:57.310><c> jeff</c></c><c.colorCCCCCC><00:03:57.610><c> Drazen</c><00:03:58.060><c> from</c><00:03:58.540><c> the</c><00:03:58.690><c> New</c><00:03:58.780><c> England</c></c>

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from jeff<c.colorCCCCCC> Drazen from the New England
 </c>

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from jeff<c.colorCCCCCC> Drazen from the New England</c>
<c.colorE5E5E5>Journal<00:03:59.050><c> of</c><00:03:59.200><c> Medicine</c></c><c.colorCCCCCC><00:03:59.290><c> an</c><00:03:59.950><c> editorial</c></c>

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<c.colorE5E5E5>Journal of Medicine</c><c.colorCCCCCC> an editorial
 </c>

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<c.colorE5E5E5>Journal of Medicine</c><c.colorCCCCCC> an editorial
published<00:04:00.790><c> there</c><00:04:01.090><c> recently</c><00:04:01.510><c> saying</c><00:04:01.780><c> that</c></c>

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published there<c.colorCCCCCC> recently saying that
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published there<c.colorCCCCCC> recently saying that
what<00:04:02.230><c> we</c><00:04:02.260><c> as</c><00:04:02.500><c> clinicians</c><00:04:02.650><c> need</c><00:04:03.489><c> to</c><00:04:03.610><c> do</c><00:04:03.760><c> is</c><00:04:04.270><c> have</c></c>

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what we<c.colorCCCCCC> as clinicians need to do is have
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what we<c.colorCCCCCC> as clinicians need to do is have
a<00:04:05.080><c> pragmatic</c></c><c.colorE5E5E5><00:04:05.770><c> head-to-head</c><00:04:06.400><c> trials</c><00:04:06.820><c> can</c><00:04:07.540><c> you</c></c>

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a pragmatic<c.colorE5E5E5> head-to-head trials can you
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a pragmatic<c.colorE5E5E5> head-to-head trials can you
see<00:04:07.810><c> those</c><00:04:07.959><c> happening</c><00:04:08.410><c> soon</c></c><c.colorCCCCCC><00:04:08.680><c> I</c></c><c.colorE5E5E5><00:04:08.920><c> don't</c></c><c.colorCCCCCC><00:04:09.780><c> like</c></c>

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see those happening soon<c.colorCCCCCC> I</c><c.colorE5E5E5> don't</c><c.colorCCCCCC> like
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see those happening soon<c.colorCCCCCC> I</c><c.colorE5E5E5> don't</c><c.colorCCCCCC> like
the<00:04:10.900><c> difficult</c><00:04:11.290><c> thing</c><00:04:11.440><c> isn't</c></c><c.colorE5E5E5><00:04:11.650><c> it</c><00:04:11.769><c> to</c><00:04:11.860><c> do</c><00:04:11.980><c> those</c></c>

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the difficult thing isn't<c.colorE5E5E5> it to do those
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the difficult thing isn't<c.colorE5E5E5> it to do those</c>
<c.colorE5E5E5>things<00:04:12.660><c> the</c><00:04:13.660><c> final</c><00:04:14.080><c> thing</c><00:04:14.350><c> that</c><00:04:14.620><c> happened</c></c>

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<c.colorE5E5E5>things the final thing that happened
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<c.colorE5E5E5>things the final thing that happened
during</c><c.colorCCCCCC><00:04:15.250><c> the</c><00:04:15.670><c> symposium</c></c><c.colorE5E5E5><00:04:16.239><c> was</c><00:04:16.660><c> that</c><00:04:16.989><c> one</c><00:04:17.169><c> of</c></c>

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during<c.colorCCCCCC> the symposium</c><c.colorE5E5E5> was that one of
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during<c.colorCCCCCC> the symposium</c><c.colorE5E5E5> was that one of
Elizabeth<00:04:17.650><c> Bell's</c><00:04:17.859><c> patients</c><00:04:19.590><c> came</c><00:04:20.590><c> on</c><00:04:20.739><c> stage</c></c>

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<c.colorE5E5E5>Elizabeth Bell's patients came on stage
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<c.colorE5E5E5>Elizabeth Bell's patients came on stage</c>
<c.colorCCCCCC>very<00:04:21.250><c> bravely</c><00:04:21.549><c> to</c><00:04:21.910><c> speak</c><00:04:22.090><c> in</c><00:04:22.210><c> English</c></c><c.colorE5E5E5><00:04:22.350><c> as</c><00:04:23.350><c> a</c></c>

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<c.colorCCCCCC>very bravely to speak in English</c><c.colorE5E5E5> as a
 </c>

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<c.colorCCCCCC>very bravely to speak in English</c><c.colorE5E5E5> as a</c>
<c.colorCCCCCC>Dutch<00:04:23.650><c> patient</c><00:04:24.039><c> and</c><00:04:24.390><c> was</c><00:04:25.390><c> really</c><00:04:25.630><c> giving</c><00:04:26.289><c> us</c></c>

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<c.colorCCCCCC>Dutch patient and was really giving us
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<c.colorCCCCCC>Dutch patient and was really giving us
an<00:04:26.440><c> indication</c></c>

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an indication
 

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an indication
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what it was<c.colorE5E5E5> like to</c><c.colorCCCCCC> have</c><c.colorE5E5E5> severe asthma
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what it was<c.colorE5E5E5> like to</c><c.colorCCCCCC> have</c><c.colorE5E5E5> severe asthma
and<00:04:28.780><c> the</c><00:04:29.260><c> impact</c><00:04:29.680><c> at</c><00:04:29.920><c> being</c><00:04:30.100><c> on</c><00:04:30.190><c> a</c><00:04:30.280><c> biologic</c></c>

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and the impact at being on a biologic
 

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and the impact at being on a biologic
made<00:04:30.910><c> for</c><00:04:31.090><c> him</c><c.colorE5E5E5><00:04:31.240><c> and</c><00:04:31.690><c> Jeff</c><00:04:32.080><c> Jason</c><00:04:32.410><c> asked</c><00:04:32.770><c> him</c></c>

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made for him<c.colorE5E5E5> and Jeff Jason asked him
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made for him<c.colorE5E5E5> and Jeff Jason asked him
one<00:04:33.580><c> question</c><00:04:33.610><c> what</c><00:04:34.210><c> was</c><00:04:34.330><c> the</c><00:04:34.360><c> one</c><00:04:34.690><c> thing</c></c><c.colorCCCCCC><00:04:34.720><c> that</c></c>

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one question what was the<c.colorE5E5E5> one thing</c><c.colorCCCCCC> that
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one question what was the<c.colorE5E5E5> one thing</c><c.colorCCCCCC> that
improves</c><c.colorE5E5E5><00:04:37.480><c> and</c><00:04:37.890><c> you</c><00:04:38.890><c> know</c></c><c.colorCCCCCC><00:04:38.950><c> III</c><00:04:39.310><c> was</c><00:04:39.820><c> very</c><00:04:40.000><c> moved</c></c>

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<c.colorCCCCCC>improves</c><c.colorE5E5E5> and you know</c><c.colorCCCCCC> III was very moved
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<c.colorCCCCCC>improves</c><c.colorE5E5E5> and you know</c><c.colorCCCCCC> III was very moved</c>
<c.colorE5E5E5>by<00:04:40.210><c> yeah</c><00:04:40.480><c> yeah</c><00:04:40.870><c> so</c><00:04:41.800><c> in</c><00:04:42.310><c> the</c><00:04:42.490><c> beginning</c><00:04:42.640><c> the</c><00:04:43.180><c> the</c></c>

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<c.colorE5E5E5>by yeah yeah so in the beginning the the
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<c.colorE5E5E5>by yeah yeah so in the beginning the the</c>
<c.colorE5E5E5>speakers<00:04:44.170><c> were</c><00:04:44.350><c> speaking</c><00:04:45.130><c> about</c><00:04:45.370><c> the</c></c>

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<c.colorE5E5E5>speakers were speaking about the
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<c.colorE5E5E5>speakers were speaking about the
importance<00:04:46.150><c> of</c><00:04:46.330><c> prednisone</c><00:04:47.430><c> dependence</c><00:04:48.430><c> and</c></c>

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importance of prednisone<c.colorE5E5E5> dependence and
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importance of prednisone<c.colorE5E5E5> dependence and
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the side effects of the drug<c.colorCCCCCC> well and
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the side effects of the drug<c.colorCCCCCC> well and</c>
<c.colorCCCCCC>turned<00:04:52.300><c> that</c><00:04:52.540><c> was</c><00:04:52.780><c> the</c><00:04:52.900><c> patient</c><00:04:53.490><c> answered</c><00:04:54.490><c> the</c></c>

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<c.colorCCCCCC>turned that was the patient answered the
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<c.colorCCCCCC>turned that was the patient answered the
question<00:04:54.970><c> he</c><00:04:55.060><c> said</c><00:04:55.300><c> what</c><00:04:55.540><c> is</c><00:04:55.720><c> most</c><00:04:55.960><c> important</c></c>

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question he said what is most important
 

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question he said what is most important
is<00:04:56.920><c> my</c><00:04:57.160><c> quality</c><00:04:57.580><c> of</c><00:04:57.670><c> life</c><c.colorE5E5E5><00:04:57.820><c> I</c><00:04:58.270><c> can</c><00:04:58.660><c> go</c><00:04:59.650><c> up</c><00:04:59.860><c> in</c></c>

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is my quality of life<c.colorE5E5E5> I can go up in
 </c>

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is my quality of life<c.colorE5E5E5> I can go up in
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stairs if I can live normally she can
 

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stairs if I can live normally she can
<c.colorCCCCCC>stream<00:05:03.300><c> so</c><00:05:04.300><c> much</c><00:05:04.450><c> fun</c><00:05:04.750><c> yeah</c><00:05:05.290><c> and</c><00:05:05.470><c> he</c></c><c.colorE5E5E5><00:05:06.190><c> very</c></c>

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<c.colorCCCCCC>stream so much fun yeah and he</c><c.colorE5E5E5> very
 </c>

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<c.colorCCCCCC>stream so much fun yeah and he</c><c.colorE5E5E5> very</c>
<c.colorCCCCCC>clearly<00:05:06.760><c> put</c></c><c.colorE5E5E5><00:05:06.910><c> it</c><00:05:07.150><c> down</c><00:05:07.330><c> to</c><00:05:07.600><c> is</c><00:05:07.750><c> that</c><00:05:07.780><c> they're</c></c>

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<c.colorCCCCCC>clearly put</c><c.colorE5E5E5> it down to is that they're
 </c>

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<c.colorCCCCCC>clearly put</c><c.colorE5E5E5> it down to is that they're
not<00:05:08.740><c> having</c></c><c.colorCCCCCC><00:05:09.280><c> to</c><00:05:09.430><c> think</c><00:05:09.460><c> about</c></c><c.colorE5E5E5><00:05:09.970><c> it</c><00:05:10.210><c> so</c><00:05:10.420><c> in</c><00:05:10.540><c> other</c></c>

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not<c.colorE5E5E5> having</c><c.colorCCCCCC> to think about</c><c.colorE5E5E5> it so in other
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not<c.colorE5E5E5> having</c><c.colorCCCCCC> to think about</c><c.colorE5E5E5> it so in other
words<00:05:10.960><c> I</c><00:05:11.260><c> don't</c><00:05:11.620><c> have</c><00:05:11.800><c> to</c><00:05:11.950><c> what</c><00:05:12.160><c> I'm</c><00:05:12.280><c> doing</c></c>

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words I<c.colorE5E5E5> don't have to what I'm doing
 </c>

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words I<c.colorE5E5E5> don't have to what I'm doing
anything</c><c.colorCCCCCC><00:05:12.790><c> or</c><00:05:13.090><c> I'm</c><00:05:13.210><c> traveling</c></c><c.colorE5E5E5><00:05:13.620><c> about</c><00:05:14.620><c> what's</c></c>

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anything<c.colorCCCCCC> or I'm traveling</c><c.colorE5E5E5> about what's
 </c>

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anything<c.colorCCCCCC> or I'm traveling</c><c.colorE5E5E5> about what's
going<00:05:15.280><c> to</c></c><c.colorCCCCCC><00:05:15.310><c> happen</c><00:05:15.640><c> with</c><00:05:15.760><c> my</c><00:05:15.910><c> severe</c><00:05:16.210><c> asthma</c><00:05:16.510><c> so</c></c>

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going to<c.colorCCCCCC> happen with my severe asthma so
 </c>

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going to<c.colorCCCCCC> happen with my severe asthma so
thank<00:05:17.140><c> you</c><00:05:17.230><c> very</c><00:05:17.350><c> much</c></c><c.colorE5E5E5><00:05:17.500><c> for</c></c><c.colorCCCCCC><00:05:17.680><c> joining</c><00:05:17.860><c> me</c></c>

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thank you<c.colorCCCCCC> very much</c><c.colorE5E5E5> for</c><c.colorCCCCCC> joining me
 </c>

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thank you<c.colorCCCCCC> very much</c><c.colorE5E5E5> for</c><c.colorCCCCCC> joining me
Emilio</c><c.colorE5E5E5><00:05:18.370><c> and</c><00:05:18.580><c> thank</c><00:05:19.030><c> you</c><00:05:19.120><c> very</c><00:05:19.240><c> much</c><00:05:19.390><c> for</c></c>

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Emilio<c.colorE5E5E5> and thank you very much for
 </c>

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Emilio<c.colorE5E5E5> and thank you very much for
joining<00:05:19.600><c> us</c><00:05:19.960><c> for</c><00:05:20.260><c> the</c><00:05:20.410><c> daily</c><00:05:20.770><c> ers</c><00:05:21.220><c> highlights</c></c>

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joining<c.colorE5E5E5> us for the daily ers highlights
 </c>

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joining<c.colorE5E5E5> us for the daily ers highlights</c>
<c.colorCCCCCC>video<00:05:21.940><c> thank</c></c><c.colorE5E5E5><00:05:22.510><c> you</c></c>