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[Music]
hello<c.colorE5E5E5><00:00:08.790><c> welcome</c></c><c.colorCCCCCC><00:00:09.360><c> to</c><00:00:09.780><c> another</c><00:00:10.019><c> edition</c><00:00:10.679><c> of</c><00:00:10.710><c> the</c></c>

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hello<c.colorE5E5E5> welcome</c><c.colorCCCCCC> to another edition of the
 </c>

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hello<c.colorE5E5E5> welcome</c><c.colorCCCCCC> to another edition of the</c>
<c.colorE5E5E5>ers<00:00:11.759><c> highlights</c></c>

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<c.colorE5E5E5>ers highlights
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<c.colorE5E5E5>ers highlights
I'm<00:00:13.110><c> Paul</c><00:00:13.410><c> Jones</c><00:00:13.650><c> I'm</c><00:00:13.950><c> a</c><00:00:14.009><c> global</c><00:00:14.280><c> medical</c></c>

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I'm Paul Jones I'm a global medical
 

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I'm Paul Jones I'm a global medical
expert<00:00:15.210><c> with</c><c.colorCCCCCC><00:00:15.389><c> GSK</c><00:00:15.929><c> and</c><00:00:16.139><c> an</c><00:00:16.650><c> emeritus</c></c>

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expert with<c.colorCCCCCC> GSK and an emeritus
 </c>

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expert with<c.colorCCCCCC> GSK and an emeritus
professor<00:00:17.220><c> of</c></c><c.colorE5E5E5><00:00:17.760><c> respiratory</c><00:00:18.240><c> medicine</c><00:00:18.650><c> some</c></c>

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professor<c.colorCCCCCC> of</c><c.colorE5E5E5> respiratory medicine some
 </c>

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professor<c.colorCCCCCC> of</c><c.colorE5E5E5> respiratory medicine some</c>
<c.colorCCCCCC>George's<00:00:20.130><c> in</c><00:00:20.279><c> London</c></c><c.colorE5E5E5><00:00:20.670><c> and</c><00:00:21.029><c> I'm</c><00:00:21.480><c> delighted</c><00:00:21.960><c> to</c></c>

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<c.colorCCCCCC>George's in London</c><c.colorE5E5E5> and I'm delighted to
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<c.colorCCCCCC>George's in London</c><c.colorE5E5E5> and I'm delighted to</c>
<c.colorCCCCCC>be<00:00:22.439><c> joined</c><00:00:22.740><c> for</c></c><c.colorE5E5E5><00:00:22.859><c> my</c><00:00:23.100><c> friend</c><00:00:23.460><c> and</c><00:00:23.730><c> colleague</c></c>

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<c.colorCCCCCC>be joined for</c><c.colorE5E5E5> my friend and colleague
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<c.colorCCCCCC>be joined for</c><c.colorE5E5E5> my friend and colleague
professor<00:00:24.720><c> Jurgen</c><00:00:25.439><c> Vespa</c><00:00:25.890><c> past</c><00:00:26.640><c> president</c><00:00:27.269><c> of</c></c>

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professor Jurgen<c.colorE5E5E5> Vespa past president of
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professor Jurgen<c.colorE5E5E5> Vespa past president of</c>
<c.colorCCCCCC>the</c><c.colorE5E5E5><00:00:27.660><c> ARS</c><00:00:28.140><c> and</c><00:00:28.380><c> also</c><00:00:29.220><c> a</c><00:00:29.250><c> very</c><00:00:29.670><c> significant</c></c>

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<c.colorCCCCCC>the</c><c.colorE5E5E5> ARS and also a very significant
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<c.colorCCCCCC>the</c><c.colorE5E5E5> ARS and also a very significant
member<00:00:30.720><c> of</c><00:00:30.869><c> God</c><00:00:31.309><c> we</c><00:00:32.309><c> were</c><00:00:32.489><c> at</c><00:00:32.700><c> a</c><00:00:32.730><c> session</c><00:00:33.239><c> about</c></c>

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member of<c.colorE5E5E5> God we were at a session about
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member of<c.colorE5E5E5> God we were at a session about
lung<00:00:34.020><c> function</c><00:00:34.500><c> testing</c><00:00:34.980><c> that</c><00:00:36.170><c> rehashed</c><00:00:37.170><c> some</c></c>

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lung function testing that<c.colorE5E5E5> rehashed some
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lung function testing that<c.colorE5E5E5> rehashed some
of<00:00:37.620><c> the</c><00:00:37.710><c> older</c><00:00:38.100><c> data</c><00:00:38.280><c> and</c><00:00:38.640><c> challenged</c><00:00:39.120><c> us</c><00:00:39.270><c> to</c></c>

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of the older<c.colorE5E5E5> data and challenged us to
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of the older<c.colorE5E5E5> data and challenged us to</c>
<c.colorE5E5E5>think</c><c.colorCCCCCC><00:00:39.510><c> about</c></c><c.colorE5E5E5><00:00:40.260><c> new</c><00:00:41.010><c> types</c><00:00:41.550><c> of</c><00:00:41.790><c> investigations</c></c>

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<c.colorE5E5E5>think</c><c.colorCCCCCC> about</c><c.colorE5E5E5> new types of investigations
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<c.colorE5E5E5>think</c><c.colorCCCCCC> about</c><c.colorE5E5E5> new types of investigations</c>
<c.colorCCCCCC>so<00:00:43.739><c> you're</c><00:00:44.070><c> there</c><00:00:44.250><c> what's</c></c><c.colorE5E5E5><00:00:44.670><c> your</c><00:00:44.820><c> overall</c></c>

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<c.colorCCCCCC>so you're there what's</c><c.colorE5E5E5> your overall
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<c.colorCCCCCC>so you're there what's</c><c.colorE5E5E5> your overall</c>
<c.colorE5E5E5>impression<00:00:45.989><c> of</c><00:00:46.200><c> that</c><00:00:46.440><c> session</c><00:00:46.890><c> I</c><00:00:47.309><c> think</c></c><c.colorCCCCCC><00:00:47.640><c> first</c></c>

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<c.colorE5E5E5>impression of that session I think</c><c.colorCCCCCC> first
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<c.colorE5E5E5>impression of that session I think</c><c.colorCCCCCC> first</c>
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<c.colorE5E5E5>of all it was a</c><c.colorCCCCCC> lively session</c><c.colorE5E5E5> because
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<c.colorE5E5E5>of all it was a</c><c.colorCCCCCC> lively session</c><c.colorE5E5E5> because
it<00:00:49.770><c> was</c><00:00:49.890><c> a</c><00:00:49.920><c> pro/con</c><00:00:50.399><c> debate</c><00:00:50.789><c> on</c><00:00:51.000><c> three</c></c>

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it was a pro/con debate on three
 

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it was a pro/con debate on three
<c.colorCCCCCC>different<00:00:51.600><c> areas</c></c><c.colorE5E5E5><00:00:51.750><c> and</c><00:00:52.170><c> I</c><00:00:52.199><c> think</c></c><c.colorCCCCCC><00:00:52.230><c> that</c><00:00:52.559><c> heats</c></c>

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<c.colorCCCCCC>different areas</c><c.colorE5E5E5> and I think</c><c.colorCCCCCC> that heats
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<c.colorCCCCCC>different areas</c><c.colorE5E5E5> and I think</c><c.colorCCCCCC> that heats
up</c><c.colorE5E5E5><00:00:53.370><c> the</c></c><c.colorCCCCCC><00:00:53.579><c> atmosphere</c><00:00:53.730><c> a</c><00:00:54.149><c> little</c></c><c.colorE5E5E5><00:00:54.329><c> and</c><00:00:54.660><c> people</c></c>

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up<c.colorE5E5E5> the</c><c.colorCCCCCC> atmosphere a little</c><c.colorE5E5E5> and people
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up<c.colorE5E5E5> the</c><c.colorCCCCCC> atmosphere a little</c><c.colorE5E5E5> and people
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get a sort of a bit more<c.colorCCCCCC> aggressive
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get a sort of a bit more<c.colorCCCCCC> aggressive</c>
<c.colorE5E5E5>perhaps<00:00:57.600><c> and</c><00:00:57.870><c> it</c><00:00:58.020><c> was</c><00:00:58.230><c> good</c></c><c.colorCCCCCC><00:00:58.469><c> I</c><00:00:58.680><c> think</c><00:00:59.309><c> it</c><00:00:59.399><c> was</c></c>

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<c.colorE5E5E5>perhaps and it was good</c><c.colorCCCCCC> I think it was
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<c.colorE5E5E5>perhaps and it was good</c><c.colorCCCCCC> I think it was
highly<00:00:59.820><c> relevant</c><00:01:00.120><c> because</c><00:01:00.780><c> I</c><00:01:00.809><c> think</c><00:01:01.199><c> first</c></c><c.colorE5E5E5><00:01:01.980><c> of</c></c>

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highly relevant<c.colorCCCCCC> because I think first</c><c.colorE5E5E5> of
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highly relevant<c.colorCCCCCC> because I think first</c><c.colorE5E5E5> of
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<c.colorE5E5E5>all it highlights that</c><c.colorCCCCCC> we sometimes
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<c.colorE5E5E5>all it highlights that</c><c.colorCCCCCC> we sometimes
forget</c><c.colorE5E5E5><00:01:04.080><c> why</c><00:01:05.040><c> we</c><00:01:05.250><c> measure</c><00:01:05.460><c> lung</c><00:01:05.700><c> function</c><00:01:06.150><c> but</c></c>

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forget<c.colorE5E5E5> why we measure lung function but
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forget<c.colorE5E5E5> why we measure lung function but
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also<c.colorE5E5E5> it got</c><c.colorCCCCCC> away from this what is the
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also<c.colorE5E5E5> it got</c><c.colorCCCCCC> away from this what is the
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best<c.colorCCCCCC> only one because I think</c><c.colorE5E5E5> that's
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best<c.colorCCCCCC> only one because I think</c><c.colorE5E5E5> that's
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<c.colorE5E5E5>what we're going to discuss that</c><c.colorCCCCCC> if it's
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<c.colorE5E5E5>what we're going to discuss that</c><c.colorCCCCCC> if it's
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a heterogeneous disease<c.colorE5E5E5> why do we</c><c.colorCCCCCC> think
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a heterogeneous disease<c.colorE5E5E5> why do we</c><c.colorCCCCCC> think
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we can have one measure<c.colorCCCCCC> I think we got
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we can have one measure<c.colorCCCCCC> I think we got
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around some of<c.colorE5E5E5> those issues</c><c.colorCCCCCC> yes I think
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around some of<c.colorE5E5E5> those issues</c><c.colorCCCCCC> yes I think
it<00:01:19.560><c> was</c><00:01:19.740><c> a</c><00:01:20.009><c> general</c><00:01:20.610><c> agreement</c></c><c.colorE5E5E5><00:01:21.150><c> one</c><00:01:21.780><c> solitary</c></c>

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it was a general<c.colorCCCCCC> agreement</c><c.colorE5E5E5> one solitary
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it was a general<c.colorCCCCCC> agreement</c><c.colorE5E5E5> one solitary
measurement<00:01:23.009><c> isn't</c><00:01:23.189><c> all</c></c><c.colorCCCCCC><00:01:23.520><c> that</c><00:01:23.820><c> we</c><00:01:23.970><c> need</c><00:01:24.210><c> we</c></c>

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measurement isn't<c.colorE5E5E5> all</c><c.colorCCCCCC> that we need we
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measurement isn't<c.colorE5E5E5> all</c><c.colorCCCCCC> that we need we
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need more<c.colorE5E5E5> data to get a more complete
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need more<c.colorE5E5E5> data to get a more complete
picture<00:01:28.009><c> so</c><00:01:29.009><c> if</c><00:01:29.100><c> we</c><00:01:29.220><c> start</c><00:01:29.490><c> with</c></c><c.colorCCCCCC><00:01:29.610><c> the</c><00:01:29.939><c> fev1</c><00:01:30.180><c> hmm</c></c>

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<c.colorE5E5E5>picture so if we start with</c><c.colorCCCCCC> the fev1 hmm
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<c.colorE5E5E5>picture so if we start with</c><c.colorCCCCCC> the fev1 hmm
it<00:01:32.009><c> seems</c><00:01:32.369><c> to</c><00:01:32.610><c> me</c><00:01:32.759><c> that</c></c><c.colorE5E5E5><00:01:34.250><c> translating</c><00:01:35.250><c> the</c></c>

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<c.colorCCCCCC>it seems to me that</c><c.colorE5E5E5> translating the
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<c.colorCCCCCC>it seems to me that</c><c.colorE5E5E5> translating the
measurements<00:01:36.329><c> into</c><00:01:36.479><c> clinical</c><00:01:37.110><c> practice</c></c>

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measurements into clinical practice
 

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measurements into clinical practice
actually<c.colorE5E5E5><00:01:38.250><c> rather</c><00:01:38.700><c> limited</c></c><c.colorCCCCCC><00:01:39.030><c> it's</c><00:01:39.720><c> essential</c></c>

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actually<c.colorE5E5E5> rather limited</c><c.colorCCCCCC> it's essential
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actually<c.colorE5E5E5> rather limited</c><c.colorCCCCCC> it's essential
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for diagnosis as a member of<c.colorE5E5E5> gold you
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for diagnosis as a member of<c.colorE5E5E5> gold you</c>
<c.colorCCCCCC>will<00:01:42.750><c> still</c><00:01:43.020><c> say</c><00:01:43.229><c> that</c><00:01:43.460><c> but</c><00:01:44.460><c> in</c></c><c.colorE5E5E5><00:01:44.729><c> terms</c><00:01:45.210><c> of</c><00:01:45.329><c> its</c></c>

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<c.colorCCCCCC>will still say that but in</c><c.colorE5E5E5> terms of its
 </c>

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<c.colorCCCCCC>will still say that but in</c><c.colorE5E5E5> terms of its</c>
<c.colorCCCCCC>contribution</c><c.colorE5E5E5><00:01:46.200><c> to</c><00:01:46.590><c> how</c><00:01:47.130><c> we</c><00:01:47.189><c> make</c><00:01:47.520><c> decisions</c></c>

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<c.colorCCCCCC>contribution</c><c.colorE5E5E5> to how we make decisions
 </c>

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<c.colorCCCCCC>contribution</c><c.colorE5E5E5> to how we make decisions</c>
<c.colorCCCCCC>what</c><c.colorE5E5E5><00:01:49.320><c> do</c><00:01:49.439><c> you</c><00:01:49.530><c> think</c><00:01:49.710><c> about</c><00:01:49.829><c> that</c><00:01:50.189><c> now</c><00:01:51.030><c> I</c><00:01:51.060><c> think</c></c>

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<c.colorCCCCCC>what</c><c.colorE5E5E5> do you think about that now I think
 </c>

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<c.colorCCCCCC>what</c><c.colorE5E5E5> do you think about that now I think
it<00:01:51.479><c> first</c><00:01:51.869><c> of</c><00:01:51.990><c> all</c><00:01:52.140><c> I'm</c><00:01:52.409><c> a</c><00:01:52.920><c> lot</c><00:01:53.790><c> in</c><00:01:54.000><c> favor</c><00:01:54.270><c> of</c></c>

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it first of all I'm a lot in<c.colorE5E5E5> favor of
 </c>

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it first of all I'm a lot in<c.colorE5E5E5> favor of
measuring<00:01:55.020><c> if</c><00:01:55.140><c> everyone</c><00:01:55.560><c> and</c><00:01:55.799><c> it</c><00:01:56.310><c> mainly</c></c>

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measuring if<c.colorE5E5E5> everyone and it mainly
 </c>

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measuring if<c.colorE5E5E5> everyone and it mainly
comes<00:01:56.850><c> because</c><00:01:57.090><c> apart</c></c><c.colorCCCCCC><00:01:58.049><c> from</c><00:01:58.170><c> being</c><00:01:58.320><c> clinician</c></c>

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comes because apart<c.colorCCCCCC> from being clinician
 </c>

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comes because apart<c.colorCCCCCC> from being clinician
I<00:01:58.950><c> see</c><00:01:59.159><c> patients</c><00:01:59.640><c> I'm</c><00:01:59.820><c> also</c><00:02:00.030><c> an</c></c>

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I see<c.colorCCCCCC> patients I'm also an
 </c>

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I see<c.colorCCCCCC> patients I'm also an
epidemiologist<00:02:00.960><c> and</c><00:02:01.229><c> fev1</c></c><c.colorE5E5E5><00:02:01.860><c> you</c><00:02:02.310><c> can</c><00:02:02.490><c> measure</c></c>

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epidemiologist and fev1<c.colorE5E5E5> you can measure
 </c>

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epidemiologist and fev1<c.colorE5E5E5> you can measure
in<00:02:02.909><c> huge</c><00:02:03.210><c> populations</c><00:02:03.990><c> and</c><00:02:04.229><c> that's</c><00:02:04.860><c> why</c><00:02:05.100><c> we</c></c>

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in huge populations<c.colorE5E5E5> and that's why we
 </c>

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in huge populations<c.colorE5E5E5> and that's why we
know<00:02:05.490><c> a</c><00:02:05.520><c> lot</c></c><c.colorCCCCCC><00:02:05.759><c> about</c><00:02:05.820><c> the</c><00:02:06.210><c> natural</c><00:02:06.360><c> history</c></c><c.colorE5E5E5><00:02:06.689><c> of</c></c>

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know a lot<c.colorCCCCCC> about the natural history</c><c.colorE5E5E5> of
 </c>

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know a lot<c.colorCCCCCC> about the natural history</c><c.colorE5E5E5> of
the<00:02:07.110><c> disease</c><00:02:07.140><c> about</c><00:02:07.710><c> progression</c></c><c.colorCCCCCC><00:02:08.280><c> of</c><00:02:08.580><c> fev1</c></c>

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<c.colorE5E5E5>the disease about progression</c><c.colorCCCCCC> of fev1
 </c>

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<c.colorE5E5E5>the disease about progression</c><c.colorCCCCCC> of fev1
and<00:02:09.390><c> we</c><00:02:10.229><c> know</c><00:02:10.410><c> it</c></c><c.colorE5E5E5><00:02:10.739><c> is</c><00:02:10.890><c> a</c><00:02:11.099><c> proper</c><00:02:11.580><c> tool</c><00:02:11.790><c> for</c></c>

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and we know it<c.colorE5E5E5> is a proper tool for
 </c>

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and we know it<c.colorE5E5E5> is a proper tool for
making<00:02:12.360><c> the</c><00:02:12.629><c> diagnosis</c></c><c.colorCCCCCC><00:02:13.230><c> of</c></c><c.colorE5E5E5><00:02:13.290><c> the</c></c>

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making<c.colorE5E5E5> the diagnosis</c><c.colorCCCCCC> of</c><c.colorE5E5E5> the
 </c>

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making<c.colorE5E5E5> the diagnosis</c><c.colorCCCCCC> of</c><c.colorE5E5E5> the</c>
<c.colorCCCCCC>Rachele<00:02:13.890><c> however</c><00:02:14.340><c> we</c><00:02:14.580><c> measure</c><00:02:14.790><c> it</c></c><c.colorE5E5E5><00:02:15.030><c> express</c></c><c.colorCCCCCC><00:02:15.660><c> it</c></c>

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<c.colorCCCCCC>Rachele however we measure it</c><c.colorE5E5E5> express</c><c.colorCCCCCC> it
 </c>

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<c.colorCCCCCC>Rachele however we measure it</c><c.colorE5E5E5> express</c><c.colorCCCCCC> it
is<00:02:16.200><c> a</c><00:02:16.260><c> good</c><00:02:16.680><c> measure</c></c><c.colorE5E5E5><00:02:17.040><c> airflow</c><00:02:17.580><c> limitation</c><00:02:17.610><c> and</c></c>

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is a good measure<c.colorE5E5E5> airflow limitation and
 </c>

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is a good measure<c.colorE5E5E5> airflow limitation and
that's<00:02:19.140><c> where</c><00:02:19.380><c> all</c><00:02:19.560><c> the</c><00:02:19.710><c> goods</c><00:02:19.890><c> things</c></c><c.colorCCCCCC><00:02:20.190><c> stop</c></c>

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that's where<c.colorE5E5E5> all the goods things</c><c.colorCCCCCC> stop
 </c>

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that's where<c.colorE5E5E5> all the goods things</c><c.colorCCCCCC> stop
because<00:02:21.720><c> first</c><00:02:21.990><c> of</c><00:02:22.170><c> all</c><00:02:22.290><c> we</c><00:02:22.590><c> can</c><00:02:23.130><c> debate</c></c><c.colorE5E5E5><00:02:23.310><c> which</c></c>

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because first of all we<c.colorCCCCCC> can debate</c><c.colorE5E5E5> which
 </c>

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because first of all we<c.colorCCCCCC> can debate</c><c.colorE5E5E5> which
cut<00:02:24.180><c> offs</c><00:02:24.390><c> of</c><00:02:24.600><c> fev1</c></c><c.colorCCCCCC><00:02:25.020><c> would</c><00:02:25.890><c> signify</c></c><c.colorE5E5E5><00:02:26.340><c> mild</c></c>

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cut offs of fev1<c.colorCCCCCC> would signify</c><c.colorE5E5E5> mild
 </c>

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cut offs of fev1<c.colorCCCCCC> would signify</c><c.colorE5E5E5> mild
moderate<00:02:27.390><c> or</c><00:02:27.570><c> severe</c><00:02:27.840><c> disease</c><00:02:28.230><c> we</c><00:02:28.980><c> know</c><00:02:29.250><c> that</c></c>

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moderate or severe disease we know that
 

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moderate or severe disease we know that
<c.colorCCCCCC>it's<00:02:30.060><c> not</c><00:02:30.270><c> predictive</c><00:02:30.960><c> of</c><00:02:31.080><c> treatment</c><00:02:31.560><c> effects</c></c>

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<c.colorCCCCCC>it's not predictive of treatment effects
 </c>

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<c.colorCCCCCC>it's not predictive of treatment effects</c>
<c.colorE5E5E5>we've<00:02:32.100><c> actually</c><00:02:32.580><c> taken</c></c><c.colorCCCCCC><00:02:32.940><c> fev1</c></c><c.colorE5E5E5><00:02:33.480><c> out</c><00:02:34.200><c> of</c><00:02:34.560><c> the</c></c>

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<c.colorE5E5E5>we've actually taken</c><c.colorCCCCCC> fev1</c><c.colorE5E5E5> out of the
 </c>

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<c.colorE5E5E5>we've actually taken</c><c.colorCCCCCC> fev1</c><c.colorE5E5E5> out of the</c>
<c.colorE5E5E5>treatment<00:02:35.070><c> recommendations</c></c><c.colorCCCCCC><00:02:35.760><c> within</c></c><c.colorE5E5E5><00:02:35.970><c> gold</c></c>

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<c.colorE5E5E5>treatment recommendations</c><c.colorCCCCCC> within</c><c.colorE5E5E5> gold
 </c>

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<c.colorE5E5E5>treatment recommendations</c><c.colorCCCCCC> within</c><c.colorE5E5E5> gold
and<00:02:36.660><c> for</c><00:02:37.560><c> the</c><00:02:37.650><c> patient</c><00:02:38.160><c> themselves</c><00:02:38.720><c> they</c><00:02:39.720><c> I</c></c>

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<c.colorE5E5E5>and for the patient themselves they I
 </c>

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<c.colorE5E5E5>and for the patient themselves they I
often<00:02:40.440><c> talk</c></c><c.colorCCCCCC><00:02:41.220><c> to</c><00:02:41.430><c> patients</c><00:02:41.640><c> who</c><00:02:42.000><c> feel</c></c><c.colorE5E5E5><00:02:42.240><c> that</c></c>

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often talk<c.colorCCCCCC> to patients who feel</c><c.colorE5E5E5> that
 </c>

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often talk<c.colorCCCCCC> to patients who feel</c><c.colorE5E5E5> that
their<00:02:42.660><c> fev1</c><00:02:42.960><c> is</c><00:02:43.380><c> not</c><00:02:43.530><c> explaining</c><00:02:44.190><c> that</c><00:02:44.310><c> today</c></c>

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<c.colorE5E5E5>their fev1 is not explaining that today
 </c>

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<c.colorE5E5E5>their fev1 is not explaining that today</c>
<c.colorE5E5E5>I'm<00:02:44.700><c> much</c><00:02:44.880><c> worse</c></c>

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<c.colorE5E5E5>I'm much worse
 </c>

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<c.colorE5E5E5>I'm much worse
or<00:02:45.450><c> it's</c><00:02:46.260><c> strange</c><00:02:46.590><c> it</c><00:02:46.710><c> hasn't</c><00:02:47.010><c> changed</c></c>

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or it's strange it hasn't changed
 

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or it's strange it hasn't changed
<c.colorCCCCCC>because<00:02:47.430><c> I</c><00:02:47.550><c> feel</c><00:02:47.760><c> much</c><00:02:47.910><c> better</c></c><c.colorE5E5E5><00:02:47.970><c> than</c><00:02:48.450><c> six</c></c>

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<c.colorCCCCCC>because I feel much better</c><c.colorE5E5E5> than six
 </c>

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<c.colorCCCCCC>because I feel much better</c><c.colorE5E5E5> than six
months</c><c.colorCCCCCC><00:02:48.840><c> ago</c><00:02:49.080><c> so</c><00:02:49.740><c> it</c><00:02:49.860><c> has</c></c><c.colorE5E5E5><00:02:50.010><c> clear</c><00:02:50.400><c> limitations</c></c>

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months<c.colorCCCCCC> ago so it has</c><c.colorE5E5E5> clear limitations
 </c>

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months<c.colorCCCCCC> ago so it has</c><c.colorE5E5E5> clear limitations
yes<00:02:52.050><c> as</c><00:02:52.290><c> a</c><00:02:52.590><c> proxy</c></c><c.colorCCCCCC><00:02:53.160><c> measure</c></c><c.colorE5E5E5><00:02:53.460><c> of</c><00:02:54.170><c> what's</c></c>

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yes<c.colorE5E5E5> as a proxy</c><c.colorCCCCCC> measure</c><c.colorE5E5E5> of what's
 </c>

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yes<c.colorE5E5E5> as a proxy</c><c.colorCCCCCC> measure</c><c.colorE5E5E5> of what's
important<00:02:55.770><c> to</c><00:02:55.860><c> the</c></c><c.colorCCCCCC><00:02:55.950><c> patient</c><00:02:56.430><c> health</c><00:02:56.850><c> status</c></c>

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important to the<c.colorCCCCCC> patient health status
 </c>

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important to the<c.colorCCCCCC> patient health status
symptoms<00:02:57.750><c> or</c><00:02:58.020><c> exercise</c><00:02:58.530><c> capacity</c></c><c.colorE5E5E5><00:02:58.770><c> is</c></c><c.colorCCCCCC><00:02:59.370><c> very</c></c>

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symptoms or exercise capacity<c.colorE5E5E5> is</c><c.colorCCCCCC> very
 </c>

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symptoms or exercise capacity<c.colorE5E5E5> is</c><c.colorCCCCCC> very
weak<00:02:59.970><c> yeah</c></c><c.colorE5E5E5><00:03:00.420><c> it</c><00:03:00.900><c> predicts</c></c><c.colorCCCCCC><00:03:01.560><c> all</c><00:03:01.680><c> core</c><00:03:01.920><c> mortality</c></c>

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weak yeah<c.colorE5E5E5> it predicts</c><c.colorCCCCCC> all core mortality
 </c>

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weak yeah<c.colorE5E5E5> it predicts</c><c.colorCCCCCC> all core mortality</c>
<c.colorE5E5E5>but<00:03:02.910><c> at</c><00:03:03.060><c> a</c><00:03:03.180><c> very</c></c><c.colorCCCCCC><00:03:03.210><c> low</c><00:03:03.660><c> level</c><00:03:03.690><c> and</c></c><c.colorE5E5E5><00:03:04.230><c> you</c></c><c.colorCCCCCC><00:03:04.590><c> taking</c></c>

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<c.colorE5E5E5>but at a very</c><c.colorCCCCCC> low level and</c><c.colorE5E5E5> you</c><c.colorCCCCCC> taking
 </c>

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<c.colorE5E5E5>but at a very</c><c.colorCCCCCC> low level and</c><c.colorE5E5E5> you</c><c.colorCCCCCC> taking
it<00:03:05.100><c> out</c><00:03:05.250><c> of</c><00:03:05.310><c> gold</c></c><c.colorE5E5E5><00:03:05.640><c> as</c><00:03:05.970><c> a</c><00:03:06.000><c> predictor</c><00:03:06.510><c> of</c></c>

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it out<c.colorCCCCCC> of gold</c><c.colorE5E5E5> as a predictor of
 </c>

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it out<c.colorCCCCCC> of gold</c><c.colorE5E5E5> as a predictor of
exacerbations<00:03:07.410><c> it</c><00:03:07.980><c> does</c><00:03:08.190><c> tell</c></c><c.colorCCCCCC><00:03:08.430><c> us</c><00:03:08.520><c> about</c></c>

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exacerbations it does tell<c.colorCCCCCC> us about
 </c>

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exacerbations it does tell<c.colorCCCCCC> us about
bronchodilators</c><c.colorE5E5E5><00:03:09.690><c> it</c><00:03:10.230><c> does</c><00:03:10.470><c> and</c><00:03:10.740><c> it</c><00:03:11.100><c> gives</c><00:03:11.340><c> us</c></c>

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bronchodilators<c.colorE5E5E5> it does and it gives us
 </c>

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bronchodilators<c.colorE5E5E5> it does and it gives us
a<00:03:11.730><c> crude</c><00:03:12.450><c> measure</c><00:03:12.990><c> of</c></c><c.colorCCCCCC><00:03:13.350><c> air</c><00:03:14.250><c> flow</c><00:03:14.640><c> sort</c><00:03:15.030><c> of</c></c>

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a crude measure of<c.colorCCCCCC> air flow sort of
 </c>

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a crude measure of<c.colorCCCCCC> air flow sort of
diameter<00:03:15.900><c> which</c><00:03:16.440><c> is</c></c><c.colorE5E5E5><00:03:16.650><c> not</c><00:03:16.920><c> perfect</c><00:03:17.190><c> but</c><00:03:18.090><c> it</c></c>

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diameter which is<c.colorE5E5E5> not perfect but it
 </c>

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diameter which is<c.colorE5E5E5> not perfect but it
does</c><c.colorCCCCCC><00:03:18.240><c> contain</c><00:03:18.810><c> predictive</c><00:03:19.470><c> value</c><00:03:19.800><c> and</c></c><c.colorE5E5E5><00:03:20.010><c> I</c></c>

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does<c.colorCCCCCC> contain predictive value and</c><c.colorE5E5E5> I
 </c>

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does<c.colorCCCCCC> contain predictive value and</c><c.colorE5E5E5> I
think<00:03:20.430><c> for</c><00:03:20.610><c> me</c><00:03:20.760><c> it</c><00:03:20.940><c> gives</c><00:03:21.090><c> me</c></c><c.colorCCCCCC><00:03:21.270><c> a</c><00:03:21.360><c> starting</c></c>

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<c.colorE5E5E5>think for me it gives me</c><c.colorCCCCCC> a starting
 </c>

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<c.colorE5E5E5>think for me it gives me</c><c.colorCCCCCC> a starting</c>
<c.colorCCCCCC>point<00:03:22.050><c> nothing</c></c><c.colorE5E5E5><00:03:22.890><c> more</c></c><c.colorCCCCCC><00:03:23.070><c> but</c><00:03:23.520><c> it's</c><00:03:23.700><c> nice</c><00:03:23.850><c> to</c><00:03:23.880><c> be</c></c>

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<c.colorCCCCCC>point nothing</c><c.colorE5E5E5> more</c><c.colorCCCCCC> but it's nice to be
 </c>

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<c.colorCCCCCC>point nothing</c><c.colorE5E5E5> more</c><c.colorCCCCCC> but it's nice to be
anchored</c><c.colorE5E5E5><00:03:24.420><c> in</c><00:03:24.750><c> something</c><00:03:25.200><c> and</c><00:03:25.320><c> then</c><00:03:25.440><c> going</c><00:03:25.770><c> on</c></c>

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anchored<c.colorE5E5E5> in something and then going on
 </c>

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anchored<c.colorE5E5E5> in something and then going on
from<00:03:26.130><c> there</c><00:03:26.340><c> and</c><00:03:27.000><c> I</c><00:03:27.150><c> think</c><00:03:27.240><c> for</c><00:03:27.390><c> instance</c></c>

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from there<c.colorE5E5E5> and I think for instance
 </c>

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from there<c.colorE5E5E5> and I think for instance
expecting<00:03:28.380><c> it</c><00:03:28.500><c> to</c><00:03:28.830><c> equate</c><00:03:29.280><c> to</c><00:03:29.310><c> breathlessness</c></c>

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<c.colorE5E5E5>expecting it to equate to breathlessness
 </c>

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<c.colorE5E5E5>expecting it to equate to breathlessness</c>
<c.colorCCCCCC>I<00:03:30.300><c> mean</c><00:03:30.900><c> if</c><00:03:31.110><c> I</c><00:03:31.230><c> want</c><00:03:31.410><c> to</c><00:03:31.500><c> know</c><00:03:31.620><c> about</c></c>

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<c.colorCCCCCC>I mean if I want to know about
 </c>

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<c.colorCCCCCC>I mean if I want to know about
breathlessness<00:03:32.250><c> why</c><00:03:32.550><c> would</c><00:03:32.820><c> I</c><00:03:32.850><c> do</c><00:03:33.000><c> a</c></c>

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breathlessness why would I do a
 

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breathlessness why would I do a
physiology<00:03:33.750><c> measure</c><c.colorE5E5E5><00:03:33.959><c> I</c><00:03:34.230><c> can</c><00:03:34.590><c> ask</c><00:03:34.740><c> the</c><00:03:34.980><c> patient</c></c>

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physiology measure<c.colorE5E5E5> I can ask the patient
 </c>

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physiology measure<c.colorE5E5E5> I can ask the patient
and<00:03:35.550><c> did</c><00:03:35.700><c> it</c><00:03:35.790><c> so</c><00:03:35.880><c> it's</c><00:03:36.360><c> about</c><00:03:36.600><c> what</c><00:03:36.810><c> we</c><00:03:36.900><c> expect</c></c>

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and<c.colorE5E5E5> did it so it's about what we expect
 </c>

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and<c.colorE5E5E5> did it so it's about what we expect
from<00:03:37.500><c> a</c><00:03:37.650><c> measure</c><00:03:37.830><c> I</c></c><c.colorCCCCCC><00:03:38.100><c> think</c><00:03:38.310><c> that's</c><00:03:38.490><c> the</c></c>

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from a measure I<c.colorCCCCCC> think that's the
 </c>

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from a measure I<c.colorCCCCCC> think that's the
crucial</c><c.colorE5E5E5><00:03:38.790><c> thing</c><00:03:39.240><c> yes</c><00:03:40.110><c> and</c><00:03:40.380><c> I</c><00:03:41.070><c> think</c></c><c.colorCCCCCC><00:03:41.400><c> the</c></c>

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crucial<c.colorE5E5E5> thing yes and I think</c><c.colorCCCCCC> the
 </c>

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crucial<c.colorE5E5E5> thing yes and I think</c><c.colorCCCCCC> the
probably<00:03:42.180><c> gone</c></c><c.colorE5E5E5><00:03:42.360><c> as</c><00:03:42.540><c> far</c><00:03:42.840><c> as</c></c><c.colorCCCCCC><00:03:42.900><c> we</c><00:03:43.230><c> can</c><00:03:43.500><c> do</c><00:03:43.680><c> in</c></c>

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<c.colorCCCCCC>probably gone</c><c.colorE5E5E5> as far as</c><c.colorCCCCCC> we can do in
 </c>

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<c.colorCCCCCC>probably gone</c><c.colorE5E5E5> as far as</c><c.colorCCCCCC> we can do in</c>
<c.colorCCCCCC>terms<00:03:44.010><c> of</c><00:03:44.190><c> the</c><00:03:44.310><c> everyone</c><00:03:44.850><c> in</c><00:03:45.060><c> new</c><00:03:45.570><c> treatments</c></c>

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<c.colorCCCCCC>terms of the everyone in new treatments
 </c>

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<c.colorCCCCCC>terms of the everyone in new treatments</c>
<c.colorE5E5E5>-<00:03:46.530><c> oh</c><00:03:46.770><c> absolutely</c></c>

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<c.colorE5E5E5>- oh absolutely
 </c>

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<c.colorE5E5E5>- oh absolutely
which<00:03:47.760><c> brings</c><00:03:48.150><c> us</c><00:03:48.360><c> to</c><00:03:48.510><c> the</c><00:03:48.780><c> other</c><00:03:48.810><c> newer</c></c>

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which brings us to<c.colorE5E5E5> the other newer
 </c>

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which brings us to<c.colorE5E5E5> the other newer
methods<00:03:50.070><c> yes</c><00:03:50.400><c> it</c><00:03:50.790><c> seems</c><00:03:51.600><c> to</c><00:03:51.720><c> me</c><00:03:51.930><c> a</c><00:03:51.959><c> primarily</c></c>

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methods<c.colorE5E5E5> yes it seems to me a primarily
 </c>

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methods<c.colorE5E5E5> yes it seems to me a primarily
focused<00:03:53.340><c> on</c><00:03:53.489><c> the</c><00:03:53.670><c> small</c></c><c.colorCCCCCC><00:03:53.970><c> Airways</c><00:03:54.390><c> which</c><00:03:54.870><c> is</c></c>

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focused on<c.colorE5E5E5> the small</c><c.colorCCCCCC> Airways which is
 </c>

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focused on<c.colorE5E5E5> the small</c><c.colorCCCCCC> Airways which is
probably<00:03:55.410><c> where</c><00:03:55.650><c> the</c><00:03:55.770><c> disease</c><00:03:56.270><c> starts</c><00:03:57.270><c> and</c></c>

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probably where the disease starts and
 

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probably where the disease starts and
<c.colorE5E5E5>it's</c><c.colorCCCCCC><00:03:58.980><c> in</c><00:03:59.250><c> although</c></c><c.colorE5E5E5><00:03:59.550><c> there</c><00:04:00.209><c> were</c><00:04:00.270><c> some</c></c>

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<c.colorE5E5E5>it's</c><c.colorCCCCCC> in although</c><c.colorE5E5E5> there were some
 </c>

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<c.colorE5E5E5>it's</c><c.colorCCCCCC> in although</c><c.colorE5E5E5> there were some</c>
<c.colorCCCCCC>examples<00:04:01.290><c> of</c><00:04:01.410><c> their</c><00:04:01.590><c> clinical</c><00:04:02.190><c> application</c></c>

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<c.colorCCCCCC>examples of their clinical application
 </c>

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<c.colorCCCCCC>examples of their clinical application
it<00:04:03.989><c> seems</c><00:04:04.470><c> that</c><00:04:05.130><c> these</c><00:04:05.370><c> are</c><00:04:05.670><c> more</c><00:04:05.880><c> research</c></c>

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it seems that these are more research
 

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it seems that these are more research
tools<00:04:06.870><c> that</c><00:04:07.140><c> could</c><c.colorE5E5E5><00:04:07.290><c> be</c></c><c.colorCCCCCC><00:04:07.350><c> used</c><00:04:07.440><c> to</c></c><c.colorE5E5E5><00:04:07.770><c> identify</c></c>

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tools that could<c.colorE5E5E5> be</c><c.colorCCCCCC> used to</c><c.colorE5E5E5> identify
 </c>

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tools that could<c.colorE5E5E5> be</c><c.colorCCCCCC> used to</c><c.colorE5E5E5> identify
therapeutic<00:04:09.630><c> targets</c><00:04:10.250><c> earlier</c><00:04:11.250><c> in</c><00:04:11.370><c> the</c></c>

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therapeutic targets earlier in the
 

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therapeutic targets earlier in the
disease<c.colorE5E5E5><00:04:11.790><c> and</c><00:04:12.090><c> end-stage</c><00:04:12.600><c> COPD</c><00:04:12.959><c> that</c><00:04:13.560><c> we</c><00:04:13.650><c> have</c></c>

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disease<c.colorE5E5E5> and end-stage COPD that we have
 </c>

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disease<c.colorE5E5E5> and end-stage COPD that we have
yes<00:04:14.370><c> I</c><00:04:14.550><c> would</c><00:04:14.760><c> imagine</c><00:04:14.970><c> that</c><00:04:15.209><c> if</c><00:04:15.420><c> you</c><00:04:15.540><c> had</c><00:04:15.720><c> a</c></c>

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yes<c.colorE5E5E5> I would imagine that if you had a
 </c>

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yes<c.colorE5E5E5> I would imagine that if you had a
new<00:04:15.989><c> biologic</c><00:04:16.709><c> that</c><00:04:16.919><c> would</c><00:04:17.160><c> reduce</c></c>

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new biologic that would reduce
 

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new biologic that would reduce
inflammation<00:04:18.720><c> in</c><00:04:18.810><c> small</c><00:04:19.080><c> Airways</c><00:04:19.500><c> and</c><00:04:19.770><c> you</c>

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inflammation in small Airways and you
 

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inflammation in small Airways and you
wanted<00:04:20.609><c> a</c><00:04:20.700><c> quick</c><00:04:20.940><c> signal</c><00:04:21.359><c> for</c><00:04:21.570><c> a</c><c.colorCCCCCC><00:04:21.600><c> phase</c><00:04:21.810><c> 2</c></c>

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wanted a quick signal for a<c.colorCCCCCC> phase 2
 </c>

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wanted a quick signal for a<c.colorCCCCCC> phase 2
study<00:04:22.350><c> you</c><00:04:22.860><c> will</c></c><c.colorE5E5E5><00:04:23.039><c> not</c><00:04:23.310><c> get</c><00:04:23.550><c> that</c><00:04:23.729><c> signal</c><00:04:24.210><c> with</c></c>

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study you will<c.colorE5E5E5> not get that signal with
 </c>

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study you will<c.colorE5E5E5> not get that signal with</c>
<c.colorCCCCCC>Fe</c>

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<c.colorCCCCCC>Fe
 </c>

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<c.colorCCCCCC>Fe</c>
<c.colorE5E5E5>one<00:04:25.009><c> over</c><00:04:25.759><c> the</c><00:04:25.819><c> symptoms</c></c><c.colorCCCCCC><00:04:26.300><c> all</c></c><c.colorE5E5E5><00:04:26.599><c> the</c><00:04:26.780><c> six</c><00:04:26.990><c> minute</c></c>

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<c.colorE5E5E5>one over the symptoms</c><c.colorCCCCCC> all</c><c.colorE5E5E5> the six minute
 </c>

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<c.colorE5E5E5>one over the symptoms</c><c.colorCCCCCC> all</c><c.colorE5E5E5> the six minute
walk<00:04:27.319><c> distance</c><00:04:27.889><c> not</c><00:04:28.129><c> even</c><00:04:28.400><c> health</c><00:04:28.639><c> status</c></c><c.colorCCCCCC><00:04:29.090><c> I</c></c>

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walk distance not even health status<c.colorCCCCCC> I
 </c>

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walk distance not even health status<c.colorCCCCCC> I
think<00:04:29.900><c> you</c><00:04:30.020><c> need</c><00:04:30.139><c> a</c></c><c.colorE5E5E5><00:04:30.199><c> measurement</c><00:04:30.800><c> of</c><00:04:31.009><c> where</c></c>

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think you need<c.colorCCCCCC> a</c><c.colorE5E5E5> measurement of where
 </c>

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think you need<c.colorCCCCCC> a</c><c.colorE5E5E5> measurement of where
things<00:04:31.610><c> are</c><00:04:31.819><c> going</c><00:04:32.000><c> on</c><00:04:32.240><c> and</c><00:04:32.449><c> that's</c><00:04:32.840><c> where</c><00:04:33.080><c> I</c></c>

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things are<c.colorE5E5E5> going on and that's where I
 </c>

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things are<c.colorE5E5E5> going on and that's where I</c>
<c.colorCCCCCC>will<00:04:33.349><c> see</c><00:04:33.470><c> multi</c><00:04:33.889><c> breath</c><00:04:34.069><c> washout</c></c><c.colorE5E5E5><00:04:34.490><c> or</c><00:04:35.000><c> the</c><00:04:35.389><c> old</c></c>

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<c.colorCCCCCC>will see multi breath washout</c><c.colorE5E5E5> or the old
 </c>

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<c.colorCCCCCC>will see multi breath washout</c><c.colorE5E5E5> or the old
single<00:04:35.870><c> breath</c><00:04:36.050><c> for</c></c><c.colorCCCCCC><00:04:36.229><c> that</c><00:04:36.319><c> matter</c><00:04:36.560><c> or</c><00:04:36.889><c> perhaps</c></c>

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single breath for<c.colorCCCCCC> that matter or perhaps
 </c>

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single breath for<c.colorCCCCCC> that matter or perhaps</c>
<c.colorE5E5E5>a<00:04:37.669><c> salami</c><00:04:38.000><c> tree</c><00:04:38.270><c> in</c><00:04:38.479><c> providing</c><00:04:39.110><c> a</c><00:04:39.319><c> tool</c><00:04:39.560><c> that</c></c>

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<c.colorE5E5E5>a salami tree in providing a tool that
 </c>

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<c.colorE5E5E5>a salami tree in providing a tool that
could<00:04:39.949><c> help</c></c><c.colorCCCCCC><00:04:40.009><c> so</c><00:04:40.669><c> clearly</c><00:04:41.180><c> for</c><00:04:41.539><c> sort</c></c><c.colorE5E5E5><00:04:41.750><c> of</c><00:04:41.840><c> more</c></c>

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could help<c.colorCCCCCC> so clearly for sort</c><c.colorE5E5E5> of more
 </c>

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could help<c.colorCCCCCC> so clearly for sort</c><c.colorE5E5E5> of more
advanced<00:04:42.949><c> physiology</c></c><c.colorCCCCCC><00:04:43.580><c> I</c><00:04:43.789><c> think</c><00:04:44.300><c> they</c><00:04:44.509><c> have</c><00:04:44.659><c> a</c></c>

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advanced physiology<c.colorCCCCCC> I think they have a
 </c>

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advanced physiology<c.colorCCCCCC> I think they have a
role<00:04:44.930><c> but</c><00:04:45.830><c> the</c><00:04:45.949><c> discussion</c><00:04:46.370><c> was</c><00:04:46.520><c> more</c><00:04:46.729><c> how</c><00:04:46.940><c> do</c></c>

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role<c.colorCCCCCC> but the discussion was more how do
 </c>

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role<c.colorCCCCCC> but the discussion was more how do
we</c><c.colorE5E5E5><00:04:47.240><c> apply</c></c><c.colorCCCCCC><00:04:47.449><c> it</c><00:04:47.599><c> in</c><00:04:47.810><c> populations</c></c><c.colorE5E5E5><00:04:48.470><c> and</c><00:04:48.650><c> patients</c></c>

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we<c.colorE5E5E5> apply</c><c.colorCCCCCC> it in populations</c><c.colorE5E5E5> and patients
 </c>

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we<c.colorE5E5E5> apply</c><c.colorCCCCCC> it in populations</c><c.colorE5E5E5> and patients
yes<00:04:49.610><c> I</c><00:04:49.940><c> will</c><00:04:50.569><c> I</c><00:04:50.720><c> was</c><00:04:50.900><c> impressed</c><00:04:51.289><c> by</c><00:04:51.500><c> the</c><00:04:51.949><c> the</c></c>

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yes I will<c.colorE5E5E5> I was impressed by the the
 </c>

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yes I will<c.colorE5E5E5> I was impressed by the the
multi<00:04:53.150><c> breath</c><00:04:53.360><c> washout</c><00:04:53.810><c> data</c><00:04:54.110><c> in</c><00:04:54.740><c> patients</c></c>

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multi breath<c.colorE5E5E5> washout data in patients
 </c>

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multi breath<c.colorE5E5E5> washout data in patients
with<00:04:56.169><c> bronchiolitis</c><00:04:57.169><c> obliterans</c></c><c.colorCCCCCC><00:04:57.669><c> no</c><00:04:58.669><c> matter</c></c>

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with bronchiolitis obliterans<c.colorCCCCCC> no matter
 </c>

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with bronchiolitis obliterans<c.colorCCCCCC> no matter
what<00:04:59.120><c> the</c><00:04:59.270><c> cause</c><00:04:59.539><c> was</c></c><c.colorE5E5E5><00:04:59.569><c> but</c><00:05:00.440><c> that's</c></c><c.colorCCCCCC><00:05:00.560><c> a</c></c><c.colorE5E5E5><00:05:00.740><c> very</c></c>

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what the cause was<c.colorE5E5E5> but that's</c><c.colorCCCCCC> a</c><c.colorE5E5E5> very
 </c>

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what the cause was<c.colorE5E5E5> but that's</c><c.colorCCCCCC> a</c><c.colorE5E5E5> very
specialized<00:05:01.880><c> groups</c><00:05:02.389><c> of</c><00:05:02.720><c> group</c><00:05:03.080><c> of</c><00:05:03.229><c> patients</c></c>

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specialized<c.colorE5E5E5> groups of group of patients
 </c>

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specialized<c.colorE5E5E5> groups of group of patients</c>
<c.colorE5E5E5>but<00:05:03.979><c> again</c><00:05:04.280><c> this</c><00:05:04.490><c> is</c><00:05:04.699><c> detecting</c><00:05:05.569><c> early</c></c>

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<c.colorE5E5E5>but again this is detecting early
 </c>

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<c.colorE5E5E5>but again this is detecting early</c>
<c.colorE5E5E5>disease<00:05:07.389><c> where</c><00:05:08.389><c> the</c></c><c.colorCCCCCC><00:05:08.419><c> FE</c></c><c.colorE5E5E5><00:05:08.810><c> one</c><00:05:09.050><c> is</c><00:05:09.229><c> not</c><00:05:09.710><c> going</c><00:05:09.919><c> to</c></c>

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<c.colorE5E5E5>disease where the</c><c.colorCCCCCC> FE</c><c.colorE5E5E5> one is not going to
 </c>

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<c.colorE5E5E5>disease where the</c><c.colorCCCCCC> FE</c><c.colorE5E5E5> one is not going to
help<00:05:10.220><c> at</c><00:05:10.430><c> all</c></c><c.colorCCCCCC><00:05:10.580><c> now</c><00:05:11.300><c> and</c><00:05:11.479><c> I</c><00:05:11.539><c> think</c><00:05:11.720><c> that's</c><00:05:11.870><c> a</c></c>

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help at all<c.colorCCCCCC> now and I think that's a
 </c>

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help at all<c.colorCCCCCC> now and I think that's a</c>
<c.colorCCCCCC>very<00:05:12.139><c> specific</c><00:05:12.380><c> example</c><00:05:12.740><c> where</c></c><c.colorE5E5E5><00:05:13.190><c> we</c><00:05:13.460><c> know</c><00:05:13.639><c> that</c></c>

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<c.colorCCCCCC>very specific example where</c><c.colorE5E5E5> we know that
 </c>

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<c.colorCCCCCC>very specific example where</c><c.colorE5E5E5> we know that</c>
<c.colorCCCCCC>if</c><c.colorE5E5E5><00:05:13.880><c> things</c><00:05:14.300><c> start</c><00:05:14.630><c> happening</c><00:05:14.810><c> in</c></c><c.colorCCCCCC><00:05:15.199><c> small</c></c>

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<c.colorCCCCCC>if</c><c.colorE5E5E5> things start happening in</c><c.colorCCCCCC> small
 </c>

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<c.colorCCCCCC>if</c><c.colorE5E5E5> things start happening in</c><c.colorCCCCCC> small</c>
<c.colorE5E5E5>Airways<00:05:15.889><c> they</c><00:05:16.490><c> will</c><00:05:16.669><c> lead</c><00:05:16.819><c> to</c><00:05:17.030><c> something</c><00:05:17.240><c> bad</c></c>

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<c.colorE5E5E5>Airways they will lead to something bad
 </c>

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<c.colorE5E5E5>Airways they will lead to something bad</c>
<c.colorCCCCCC>so<00:05:17.900><c> if</c><00:05:17.960><c> you're</c><00:05:18.080><c> a</c><00:05:18.110><c> post</c><00:05:18.380><c> transplant</c><00:05:18.740><c> patient</c></c>

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<c.colorCCCCCC>so if you're a post transplant patient
 </c>

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<c.colorCCCCCC>so if you're a post transplant patient</c>
<c.colorE5E5E5>you<00:05:19.729><c> don't</c><00:05:19.940><c> want</c><00:05:20.150><c> things</c><00:05:20.389><c> to</c><00:05:20.569><c> get</c><00:05:20.690><c> worse</c><00:05:20.900><c> in</c></c>

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<c.colorE5E5E5>you don't want things to get worse in
 </c>

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<c.colorE5E5E5>you don't want things to get worse in
your<00:05:21.169><c> small</c><00:05:21.500><c> Airways</c><00:05:21.889><c> of</c><00:05:22.069><c> course</c><00:05:22.849><c> if</c><00:05:23.060><c> you</c><00:05:23.509><c> are</c></c>

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your<c.colorE5E5E5> small Airways of course if you are
 </c>

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your<c.colorE5E5E5> small Airways of course if you are
a<00:05:23.750><c> smoker</c><00:05:24.080><c> or</c><00:05:24.379><c> exposed</c><00:05:24.889><c> to</c><00:05:25.069><c> things</c><00:05:25.250><c> that</c><00:05:25.490><c> might</c></c>

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a smoker or exposed to things that might
 

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a smoker or exposed to things that might
give<00:05:26.270><c> you</c><c.colorCCCCCC><00:05:26.389><c> C</c><00:05:26.599><c> or</c><00:05:26.719><c> D</c><00:05:26.810><c> you</c><00:05:26.930><c> don't</c></c><c.colorE5E5E5><00:05:27.229><c> want</c><00:05:27.469><c> things</c></c>

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give you<c.colorCCCCCC> C or D you don't</c><c.colorE5E5E5> want things
 </c>

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give you<c.colorCCCCCC> C or D you don't</c><c.colorE5E5E5> want things
happening<00:05:28.159><c> in</c><00:05:28.250><c> the</c></c><c.colorCCCCCC><00:05:28.340><c> small</c><00:05:28.610><c> Airways</c></c><c.colorE5E5E5><00:05:28.909><c> either</c></c>

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happening<c.colorE5E5E5> in the</c><c.colorCCCCCC> small Airways</c><c.colorE5E5E5> either
 </c>

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happening<c.colorE5E5E5> in the</c><c.colorCCCCCC> small Airways</c><c.colorE5E5E5> either
but<00:05:30.259><c> I</c><00:05:30.289><c> think</c><00:05:30.500><c> there's</c><00:05:30.650><c> a</c><00:05:30.710><c> history</c><00:05:31.099><c> from</c><00:05:31.340><c> when</c></c>

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but I<c.colorE5E5E5> think there's a history from when
 </c>

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but I<c.colorE5E5E5> think there's a history from when
we<00:05:31.819><c> try</c><00:05:32.270><c> to</c><00:05:32.330><c> apply</c><00:05:32.750><c> single</c><00:05:33.259><c> breath</c><00:05:33.440><c> nitrogen</c></c>

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we try<c.colorE5E5E5> to apply single breath nitrogen
 </c>

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we try<c.colorE5E5E5> to apply single breath nitrogen</c>
<c.colorCCCCCC>tests</c><c.colorE5E5E5><00:05:34.250><c> to</c><00:05:34.789><c> populations</c><00:05:35.479><c> and</c></c><c.colorCCCCCC><00:05:35.690><c> showed</c><00:05:35.900><c> that</c><00:05:35.930><c> a</c></c>

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<c.colorCCCCCC>tests</c><c.colorE5E5E5> to populations and</c><c.colorCCCCCC> showed that a
 </c>

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<c.colorCCCCCC>tests</c><c.colorE5E5E5> to populations and</c><c.colorCCCCCC> showed that a
lot<00:05:36.800><c> of</c></c><c.colorE5E5E5><00:05:36.830><c> patients</c></c><c.colorCCCCCC><00:05:37.069><c> had</c><00:05:37.490><c> abnormal</c></c><c.colorE5E5E5><00:05:37.789><c> values</c><00:05:38.360><c> but</c></c>

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lot of<c.colorE5E5E5> patients</c><c.colorCCCCCC> had abnormal</c><c.colorE5E5E5> values but
 </c>

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lot of<c.colorE5E5E5> patients</c><c.colorCCCCCC> had abnormal</c><c.colorE5E5E5> values but
didn't<00:05:39.409><c> go</c><00:05:39.530><c> on</c><00:05:39.710><c> to</c><00:05:39.830><c> develop</c></c><c.colorCCCCCC><00:05:40.039><c> c</c><00:05:40.400><c> over</c><00:05:40.639><c> d</c></c><c.colorE5E5E5><00:05:40.669><c> so</c><00:05:41.210><c> it's</c></c>

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didn't go on to<c.colorE5E5E5> develop</c><c.colorCCCCCC> c over d</c><c.colorE5E5E5> so it's
 </c>

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didn't go on to<c.colorE5E5E5> develop</c><c.colorCCCCCC> c over d</c><c.colorE5E5E5> so it's
not<00:05:41.539><c> a</c><00:05:41.599><c> really</c></c><c.colorCCCCCC><00:05:42.110><c> good</c><00:05:42.349><c> mark</c><00:05:42.800><c> of</c><00:05:43.009><c> early</c><00:05:43.310><c> disease</c></c>

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not a really<c.colorCCCCCC> good mark of early disease
 </c>

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not a really<c.colorCCCCCC> good mark of early disease
it's<00:05:43.849><c> a</c><00:05:43.940><c> mark</c><00:05:44.150><c> of</c><00:05:44.240><c> something</c></c><c.colorE5E5E5><00:05:44.599><c> going</c><00:05:44.840><c> on</c><00:05:44.960><c> but</c><00:05:45.620><c> it</c></c>

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it's a mark of something<c.colorE5E5E5> going on but it
 </c>

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it's a mark of something<c.colorE5E5E5> going on but it
may</c><c.colorCCCCCC><00:05:45.949><c> not</c></c><c.colorE5E5E5><00:05:46.190><c> lead</c><00:05:46.370><c> to</c><00:05:46.400><c> disease</c></c><c.colorCCCCCC><00:05:46.880><c> and</c><00:05:47.150><c> that's</c><00:05:47.270><c> where</c></c>

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may<c.colorCCCCCC> not</c><c.colorE5E5E5> lead to disease</c><c.colorCCCCCC> and that's where
 </c>

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may<c.colorCCCCCC> not</c><c.colorE5E5E5> lead to disease</c><c.colorCCCCCC> and that's where
we<00:05:48.979><c> want</c><00:05:49.219><c> to</c><00:05:49.310><c> be</c></c><c.colorE5E5E5><00:05:49.639><c> I</c><00:05:50.020><c> was</c><00:05:51.020><c> put</c><00:05:51.349><c> in</c></c><c.colorCCCCCC><00:05:51.469><c> my</c></c><c.colorE5E5E5><00:05:51.620><c> place</c><00:05:51.860><c> by</c></c>

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we want to<c.colorCCCCCC> be</c><c.colorE5E5E5> I was put in</c><c.colorCCCCCC> my</c><c.colorE5E5E5> place by
 </c>

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we want to<c.colorCCCCCC> be</c><c.colorE5E5E5> I was put in</c><c.colorCCCCCC> my</c><c.colorE5E5E5> place by
by<00:05:52.400><c> my</c><00:05:53.000><c> question</c><00:05:53.449><c> about</c><00:05:53.690><c> effort</c></c><c.colorCCCCCC><00:05:54.169><c> II</c><00:05:54.349><c> when</c><00:05:54.620><c> when</c></c>

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by my question about<c.colorE5E5E5> effort</c><c.colorCCCCCC> II when when
 </c>

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by my question about<c.colorE5E5E5> effort</c><c.colorCCCCCC> II when when
Peter</c><c.colorE5E5E5><00:05:55.460><c> Kelly</c><00:05:56.000><c> says</c><00:05:56.240><c> it</c><00:05:56.690><c> helps</c><00:05:57.169><c> in</c><00:05:57.319><c> my</c><00:05:57.800><c> disease</c></c>

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Peter<c.colorE5E5E5> Kelly says it helps in my disease
 </c>

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Peter<c.colorE5E5E5> Kelly says it helps in my disease
management<00:05:58.639><c> and</c><00:05:59.060><c> he</c><00:05:59.330><c> actually</c><00:05:59.479><c> didn't</c><00:06:00.050><c> give</c></c>

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management<c.colorE5E5E5> and he actually didn't give
 </c>

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management<c.colorE5E5E5> and he actually didn't give
me<00:06:00.440><c> a</c><00:06:00.469><c> direct</c><00:06:00.860><c> answer</c><00:06:01.009><c> when</c><00:06:01.310><c> I</c><00:06:01.430><c> asked</c><00:06:01.759><c> him</c><00:06:01.819><c> for</c></c>

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me a<c.colorE5E5E5> direct answer when I asked him for
 </c>

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me a<c.colorE5E5E5> direct answer when I asked him for</c>
<c.colorCCCCCC>a<00:06:02.060><c> specific</c></c><c.colorE5E5E5><00:06:02.300><c> example</c><00:06:03.020><c> but</c><00:06:03.949><c> I</c><00:06:04.190><c> was</c><00:06:04.789><c> impressed</c></c>

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<c.colorCCCCCC>a specific</c><c.colorE5E5E5> example but I was impressed
 </c>

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<c.colorCCCCCC>a specific</c><c.colorE5E5E5> example but I was impressed
by</c><c.colorCCCCCC><00:06:05.360><c> the</c><00:06:05.509><c> answer</c><00:06:06.050><c> in</c><00:06:06.229><c> all</c><00:06:06.500><c> the</c><00:06:06.800><c> people</c><00:06:07.190><c> who</c><00:06:07.310><c> are</c></c>

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<c.colorE5E5E5>by</c><c.colorCCCCCC> the answer in all the people who are
 </c>

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<c.colorE5E5E5>by</c><c.colorCCCCCC> the answer in all the people who are
cognitively</c><c.colorE5E5E5><00:06:08.029><c> impaired</c><00:06:08.509><c> who</c><00:06:08.960><c> can't</c></c><c.colorCCCCCC><00:06:09.349><c> let</c><00:06:09.620><c> a</c></c>

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<c.colorCCCCCC>cognitively</c><c.colorE5E5E5> impaired who can't</c><c.colorCCCCCC> let a
 </c>

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<c.colorCCCCCC>cognitively</c><c.colorE5E5E5> impaired who can't</c><c.colorCCCCCC> let a
force</c><c.colorE5E5E5><00:06:09.949><c> expertly</c><00:06:10.729><c> maneuver</c><00:06:11.330><c> it</c><00:06:11.690><c> help</c><00:06:12.050><c> exclude</c></c>

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force<c.colorE5E5E5> expertly maneuver it help exclude
 </c>

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force<c.colorE5E5E5> expertly maneuver it help exclude
significant<00:06:13.789><c> Airways</c><00:06:14.539><c> disease</c><00:06:14.569><c> and</c><00:06:15.349><c> I</c></c>

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significant Airways disease<c.colorE5E5E5> and I
 </c>

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significant Airways disease<c.colorE5E5E5> and I
thought<00:06:15.620><c> that</c><00:06:15.830><c> was</c><00:06:15.979><c> a</c><00:06:16.009><c> nice</c><00:06:16.580><c> application</c></c><c.colorCCCCCC><00:06:16.880><c> I</c></c>

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thought that was a nice application<c.colorCCCCCC> I
 </c>

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thought that was a nice application<c.colorCCCCCC> I
think<00:06:17.779><c> it</c><00:06:18.110><c> is</c><00:06:18.229><c> because</c><00:06:18.560><c> there</c><00:06:18.740><c> are</c><00:06:18.830><c> a</c><00:06:18.860><c> lot</c><00:06:18.919><c> of</c></c>

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think<c.colorCCCCCC> it is because there are a lot of
 </c>

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think<c.colorCCCCCC> it is because there are a lot of</c>
<c.colorE5E5E5>elderly<00:06:19.490><c> patients</c></c><c.colorCCCCCC><00:06:19.759><c> who</c></c><c.colorE5E5E5><00:06:20.120><c> have</c></c>

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<c.colorE5E5E5>elderly patients</c><c.colorCCCCCC> who</c><c.colorE5E5E5> have
 </c>

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<c.colorE5E5E5>elderly patients</c><c.colorCCCCCC> who</c><c.colorE5E5E5> have
uncharacteristic<00:06:21.979><c> symptoms</c><00:06:22.490><c> that</c><00:06:22.669><c> may</c></c>

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uncharacteristic symptoms that may
 

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uncharacteristic symptoms that may
include<00:06:23.150><c> breathlessness</c><c.colorE5E5E5><00:06:23.719><c> and</c></c><c.colorCCCCCC><00:06:23.870><c> if</c><00:06:24.169><c> they</c><00:06:24.289><c> have</c></c>

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include breathlessness<c.colorE5E5E5> and</c><c.colorCCCCCC> if they have
 </c>

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include breathlessness<c.colorE5E5E5> and</c><c.colorCCCCCC> if they have
a<00:06:24.469><c> smoking</c></c><c.colorE5E5E5><00:06:24.800><c> history</c><00:06:25.069><c> it's</c><00:06:25.580><c> becoming</c><00:06:26.180><c> very</c></c>

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a smoking<c.colorE5E5E5> history it's becoming very
 </c>

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a smoking<c.colorE5E5E5> history it's becoming very
fashionable<00:06:26.960><c> say</c><00:06:27.139><c> they</c><00:06:27.319><c> probably</c><00:06:27.500><c> have</c><00:06:27.770><c> COPD</c></c>

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fashionable say they probably<c.colorE5E5E5> have COPD
 </c>

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fashionable say they probably<c.colorE5E5E5> have COPD</c>
<c.colorCCCCCC>and<00:06:28.580><c> then</c><00:06:29.240><c> you</c><00:06:29.330><c> start</c></c><c.colorE5E5E5><00:06:29.569><c> treating</c><00:06:29.990><c> them</c><00:06:30.110><c> and</c></c>

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<c.colorCCCCCC>and then you start</c><c.colorE5E5E5> treating them and
 </c>

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<c.colorCCCCCC>and then you start</c><c.colorE5E5E5> treating them and
although<00:06:30.560><c> we</c><00:06:30.889><c> know</c><00:06:31.009><c> our</c><00:06:31.219><c> treatments</c><00:06:31.819><c> are</c></c><c.colorCCCCCC><00:06:31.940><c> safe</c></c>

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although<c.colorE5E5E5> we know our treatments are</c><c.colorCCCCCC> safe
 </c>

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although<c.colorE5E5E5> we know our treatments are</c><c.colorCCCCCC> safe</c>
<c.colorE5E5E5>and</c><c.colorCCCCCC><00:06:32.509><c> all</c><00:06:32.599><c> that</c><00:06:32.779><c> you</c></c><c.colorE5E5E5><00:06:32.960><c> don't</c><00:06:33.169><c> want</c><00:06:33.320><c> to</c><00:06:33.409><c> over</c></c>

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<c.colorE5E5E5>and</c><c.colorCCCCCC> all that you</c><c.colorE5E5E5> don't want to over
 </c>

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<c.colorE5E5E5>and</c><c.colorCCCCCC> all that you</c><c.colorE5E5E5> don't want to over
treat<00:06:33.889><c> people</c><00:06:34.180><c> especially</c><00:06:35.180><c> not</c><00:06:35.270><c> the</c><00:06:35.509><c> elderly</c></c>

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treat people<c.colorE5E5E5> especially not the elderly
 </c>

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treat people<c.colorE5E5E5> especially not the elderly</c>
<c.colorCCCCCC>so<00:06:36.500><c> I</c><00:06:36.529><c> think</c><00:06:36.649><c> for</c><00:06:36.949><c> making</c><00:06:37.250><c> sure</c><00:06:37.460><c> that</c></c>

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<c.colorCCCCCC>so I think for making sure that
 </c>

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<c.colorCCCCCC>so I think for making sure that
in<00:06:38.550><c> this</c></c><c.colorE5E5E5><00:06:38.730><c> patient</c><00:06:39.150><c> it's</c></c><c.colorCCCCCC><00:06:39.270><c> not</c><00:06:39.420><c> relevant</c><00:06:39.630><c> I</c></c>

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in this<c.colorE5E5E5> patient it's</c><c.colorCCCCCC> not relevant I
 </c>

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in this<c.colorE5E5E5> patient it's</c><c.colorCCCCCC> not relevant I
don't<00:06:40.290><c> have</c><00:06:40.440><c> spirometry</c><00:06:40.800><c> but</c><00:06:41.430><c> I'm</c></c><c.colorE5E5E5><00:06:41.550><c> happy</c><00:06:41.880><c> with</c></c>

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don't have spirometry<c.colorCCCCCC> but I'm</c><c.colorE5E5E5> happy with
 </c>

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don't have spirometry<c.colorCCCCCC> but I'm</c><c.colorE5E5E5> happy with</c>
<c.colorE5E5E5>what<00:06:42.210><c> I</c><00:06:42.240><c> have</c><00:06:42.540><c> I</c><00:06:42.690><c> thought</c><00:06:43.080><c> that</c><00:06:43.260><c> was</c><00:06:43.380><c> a</c><00:06:43.410><c> good</c></c>

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<c.colorE5E5E5>what I have I thought that was a good
 </c>

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<c.colorE5E5E5>what I have I thought that was a good
answer<00:06:43.650><c> as</c><00:06:43.950><c> well</c></c><c.colorCCCCCC><00:06:44.100><c> I</c></c><c.colorE5E5E5><00:06:44.160><c> like</c><00:06:44.460><c> that</c><00:06:44.670><c> one</c><00:06:44.820><c> yes</c><00:06:45.090><c> yes</c></c>

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answer as well<c.colorCCCCCC> I</c><c.colorE5E5E5> like that one yes yes
 </c>

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answer as well<c.colorCCCCCC> I</c><c.colorE5E5E5> like that one yes yes</c>
<c.colorE5E5E5>children<00:06:46.139><c> wait</c><00:06:47.419><c> it's</c><00:06:48.419><c> not</c><00:06:48.600><c> telling</c><00:06:48.960><c> us</c><00:06:49.050><c> about</c></c>

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<c.colorE5E5E5>children wait it's not telling us about
 </c>

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<c.colorE5E5E5>children wait it's not telling us about
the<00:06:49.530><c> disease</c><00:06:49.889><c> is</c><00:06:50.130><c> moving</c><00:06:50.700><c> the</c><00:06:50.820><c> measurement</c></c>

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<c.colorE5E5E5>the disease is moving the measurement
 </c>

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<c.colorE5E5E5>the disease is moving the measurement
into<00:06:51.419><c> patient</c><00:06:51.930><c> groups</c><00:06:52.139><c> who</c><00:06:52.500><c> we</c><00:06:52.650><c> couldn't</c></c>

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into<c.colorE5E5E5> patient groups who we couldn't
 </c>

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into<c.colorE5E5E5> patient groups who we couldn't</c>
<c.colorE5E5E5>measure<00:06:53.130><c> before</c><00:06:53.430><c> yes</c><00:06:53.910><c> and</c><00:06:54.150><c> then</c><00:06:54.720><c> I</c><00:06:54.990><c> would</c><00:06:55.500><c> like</c></c>

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<c.colorE5E5E5>measure before yes and then I would like
 </c>

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<c.colorE5E5E5>measure before yes and then I would like
a<00:06:55.980><c> test</c><00:06:56.340><c> that</c><00:06:56.880><c> seemed</c><00:06:57.540><c> more</c><00:06:58.010><c> attractive</c></c><c.colorCCCCCC><00:06:59.010><c> to</c></c>

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a test<c.colorE5E5E5> that seemed more attractive</c><c.colorCCCCCC> to
 </c>

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a test<c.colorE5E5E5> that seemed more attractive</c><c.colorCCCCCC> to
GPS</c><c.colorE5E5E5><00:07:00.000><c> and</c><00:07:00.330><c> so</c><00:07:01.110><c> none</c><00:07:01.470><c> pulmonologist</c><00:07:02.250><c> who</c></c><c.colorCCCCCC><00:07:02.490><c> don't</c></c>

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GPS<c.colorE5E5E5> and so none pulmonologist who</c><c.colorCCCCCC> don't
 </c>

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GPS<c.colorE5E5E5> and so none pulmonologist who</c><c.colorCCCCCC> don't
do<00:07:03.120><c> spirometry</c><00:07:03.510><c> and</c><00:07:04.050><c> I</c><00:07:04.440><c> think</c><00:07:04.650><c> it</c><00:07:04.800><c> is</c></c>

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do spirometry<c.colorCCCCCC> and I think it is
 </c>

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do spirometry<c.colorCCCCCC> and I think it is</c>
<c.colorE5E5E5>overcoming<00:07:06.030><c> that</c><00:07:06.150><c> actually</c><00:07:06.540><c> you</c><00:07:06.630><c> have</c><00:07:06.810><c> to</c></c>

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<c.colorE5E5E5>overcoming that actually you have to
 </c>

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<c.colorE5E5E5>overcoming that actually you have to
make<00:07:07.650><c> first</c><00:07:07.980><c> explorations</c><00:07:08.790><c> where</c><00:07:09.000><c> you</c><00:07:09.090><c> have</c></c>

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make first explorations where you have
 

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make first explorations where you have
to<00:07:09.540><c> shout</c><c.colorE5E5E5><00:07:10.320><c> a</c></c><c.colorCCCCCC><00:07:10.350><c> patient's</c></c><c.colorE5E5E5><00:07:11.010><c> so</c><00:07:11.220><c> make</c></c><c.colorCCCCCC><00:07:11.400><c> sure</c><00:07:11.640><c> they</c></c>

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to shout<c.colorE5E5E5> a</c><c.colorCCCCCC> patient's</c><c.colorE5E5E5> so make</c><c.colorCCCCCC> sure they
 </c>

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to shout<c.colorE5E5E5> a</c><c.colorCCCCCC> patient's</c><c.colorE5E5E5> so make</c><c.colorCCCCCC> sure they
do</c><c.colorE5E5E5><00:07:11.910><c> the</c></c><c.colorCCCCCC><00:07:12.120><c> right</c><00:07:12.270><c> thing</c><00:07:12.540><c> I</c><00:07:12.690><c> don't</c><00:07:13.169><c> think</c><00:07:13.230><c> health</c></c>

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do<c.colorE5E5E5> the</c><c.colorCCCCCC> right thing I don't think health
 </c>

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do<c.colorE5E5E5> the</c><c.colorCCCCCC> right thing I don't think health
professionals</c><c.colorE5E5E5><00:07:14.130><c> like</c><00:07:14.490><c> being</c><00:07:14.940><c> mean</c><00:07:15.150><c> to</c></c>

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professionals<c.colorE5E5E5> like being mean to
 </c>

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professionals<c.colorE5E5E5> like being mean to
patients<00:07:15.900><c> I</c><00:07:16.020><c> hope</c><00:07:16.290><c> not</c><00:07:16.470><c> at</c><00:07:16.680><c> least</c><00:07:16.800><c> and</c><00:07:17.520><c> that's</c></c>

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patients I hope not at least and<c.colorE5E5E5> that's
 </c>

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patients I hope not at least and<c.colorE5E5E5> that's
why<00:07:17.850><c> if</c><00:07:18.150><c> we</c></c><c.colorCCCCCC><00:07:18.210><c> had</c><00:07:18.600><c> a</c><00:07:18.630><c> test</c><00:07:18.930><c> that</c><00:07:19.200><c> was</c><00:07:19.350><c> more</c></c>

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why if we<c.colorCCCCCC> had a test that was more
 </c>

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why if we<c.colorCCCCCC> had a test that was more
acceptable</c><c.colorE5E5E5><00:07:20.010><c> I</c><00:07:20.220><c> think</c><00:07:20.430><c> we</c><00:07:20.669><c> would</c></c><c.colorCCCCCC><00:07:20.790><c> do</c><00:07:20.910><c> much</c></c>

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acceptable<c.colorE5E5E5> I think we would</c><c.colorCCCCCC> do much
 </c>

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acceptable<c.colorE5E5E5> I think we would</c><c.colorCCCCCC> do much</c>
<c.colorCCCCCC>better<00:07:21.360><c> and</c><00:07:21.630><c> it's</c><00:07:21.870><c> a</c><00:07:21.990><c> very</c><00:07:22.200><c> good</c><00:07:22.350><c> point</c><00:07:22.590><c> I</c><00:07:22.950><c> hope</c></c>

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<c.colorCCCCCC>better and it's a very good point I hope
 </c>

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<c.colorCCCCCC>better and it's a very good point I hope</c>
<c.colorE5E5E5>you'll<00:07:23.280><c> get</c><00:07:23.430><c> there</c><00:07:23.669><c> we</c><00:07:24.000><c> weren't</c><00:07:24.240><c> quite</c><00:07:24.540><c> there</c></c>

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<c.colorE5E5E5>you'll get there we weren't quite there
 </c>

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<c.colorE5E5E5>you'll get there we weren't quite there
yet</c>

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yet
 

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yet
so<00:07:26.460><c> to</c><c.colorE5E5E5><00:07:27.060><c> summarize</c><00:07:27.620><c> Jurgen</c><00:07:28.620><c> and</c><00:07:28.800><c> I</c><00:07:28.860><c> both</c></c><c.colorCCCCCC><00:07:29.370><c> feel</c></c>

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so to<c.colorE5E5E5> summarize Jurgen and I both</c><c.colorCCCCCC> feel
 </c>

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so to<c.colorE5E5E5> summarize Jurgen and I both</c><c.colorCCCCCC> feel
that<00:07:29.750><c> that</c><00:07:30.750><c> the</c><00:07:31.050><c> f1</c><00:07:31.650><c> is</c><00:07:31.830><c> an</c><00:07:32.040><c> essential</c></c>

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that that the<c.colorCCCCCC> f1 is an essential
 </c>

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that that the<c.colorCCCCCC> f1 is an essential
measurement<00:07:33.479><c> to</c><00:07:33.810><c> diagnose</c><00:07:34.350><c> COPD</c></c><c.colorE5E5E5><00:07:35.389><c> but</c><00:07:36.389><c> it</c><00:07:36.540><c> has</c></c>

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measurement to diagnose COPD<c.colorE5E5E5> but it has
 </c>

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measurement to diagnose COPD<c.colorE5E5E5> but it has
limited<00:07:37.470><c> application</c><00:07:38.220><c> in</c><00:07:38.340><c> routine</c></c>

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limited application in routine
 

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limited application in routine
management<c.colorCCCCCC><00:07:39.300><c> after</c><00:07:39.780><c> that</c><00:07:39.960><c> we're</c><00:07:40.830><c> both</c><00:07:41.010><c> quite</c></c>

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management<c.colorCCCCCC> after that we're both quite
 </c>

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management<c.colorCCCCCC> after that we're both quite
excited<00:07:42.270><c> about</c></c><c.colorE5E5E5><00:07:42.419><c> the</c><00:07:42.900><c> use</c></c><c.colorCCCCCC><00:07:43.050><c> of</c><00:07:43.320><c> new</c><00:07:43.650><c> techniques</c></c>

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excited about<c.colorE5E5E5> the use</c><c.colorCCCCCC> of new techniques
 </c>

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excited about<c.colorE5E5E5> the use</c><c.colorCCCCCC> of new techniques</c>
<c.colorCCCCCC>to<00:07:44.790><c> look</c><00:07:44.910><c> at</c><00:07:45.120><c> small</c><00:07:45.540><c> Airways</c><00:07:45.990><c> disease</c><00:07:46.020><c> much</c></c>

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<c.colorCCCCCC>to look at small Airways disease much
 </c>

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<c.colorCCCCCC>to look at small Airways disease much
earlier<00:07:47.430><c> in</c><00:07:47.610><c> disease</c><00:07:47.970><c> development</c><00:07:48.540><c> that</c></c>

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earlier in disease development<c.colorCCCCCC> that
 </c>

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earlier in disease development<c.colorCCCCCC> that
might<00:07:49.380><c> help</c><00:07:49.620><c> us</c><00:07:49.890><c> target</c></c><c.colorE5E5E5><00:07:50.430><c> and</c><00:07:50.820><c> identify</c><00:07:51.600><c> new</c></c>

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might help us target<c.colorE5E5E5> and identify new
 </c>

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might help us target<c.colorE5E5E5> and identify new
treatments<00:07:52.560><c> so</c><00:07:53.490><c> with</c><00:07:53.610><c> that</c><00:07:53.729><c> I'd</c><00:07:53.940><c> like</c><00:07:54.120><c> to</c></c>

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treatments<c.colorE5E5E5> so with that I'd like to
 </c>

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treatments<c.colorE5E5E5> so with that I'd like to</c>
<c.colorE5E5E5>thank</c><c.colorCCCCCC><00:07:54.330><c> you</c></c><c.colorE5E5E5><00:07:54.660><c> very</c><00:07:54.810><c> much</c><00:07:55.050><c> for</c><00:07:55.260><c> joining</c><00:07:55.320><c> us</c><00:07:55.800><c> and</c></c>

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<c.colorE5E5E5>thank</c><c.colorCCCCCC> you</c><c.colorE5E5E5> very much for joining us and
 </c>

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<c.colorE5E5E5>thank</c><c.colorCCCCCC> you</c><c.colorE5E5E5> very much for joining us and
remember<00:07:56.100><c> there</c><00:07:56.850><c> will</c><00:07:57.060><c> be</c><00:07:57.090><c> more</c><00:07:57.479><c> reports</c></c><c.colorCCCCCC><00:07:58.020><c> from</c></c>

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remember there will be more reports<c.colorCCCCCC> from
 </c>

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remember there will be more reports<c.colorCCCCCC> from
the<00:07:58.320><c> eros</c><00:07:58.890><c> over</c><00:07:59.370><c> the</c><00:07:59.520><c> next</c><00:07:59.729><c> few</c></c><c.colorE5E5E5><00:07:59.940><c> days</c></c>

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the<c.colorCCCCCC> eros over the next few</c><c.colorE5E5E5> days
 </c>

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the<c.colorCCCCCC> eros over the next few</c><c.colorE5E5E5> days
thank<00:08:00.750><c> you</c><00:08:00.870><c> very</c><00:08:00.900><c> much</c></c>