BEXSERO MOA

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BEXSERO: Mechanism of action 1*

BEXSERO was developed, using a multiple antigen approach. Immunization with BEXSERO is intended to raise the titer of bactericidal antibodies that specifically bind the vaccine antigens fHbp, NadA, NHBA and PorA P1.4 (the immunodominant antigen present in the OMV component). 1*

fHbp
Factor H binding protein

NadA
Neisserial adhesin A

NHBA
Neisseria Heparin Binding Antigen

OMV
Outer Membrane Vesicles that contain PorA 1.4

* Clinical significance unknown.

Reference:

BEXSERO Product Monograph. February 25, 2019.

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BEXSERO: Mechanism of action 1*

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