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SHINGRIX mechanism of action

SHINGRIX is designed to induce cellular and humoral immune responses to VZV 1*

SHINGRIX combines a non-live antigen with an Adjuvant System 1*

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Visual shows the interaction of the antigen and adjuvant components of SHINGRIX. For any additional questions please call GSK customer service at 1-800-387-7374.



Glycoprotein E (gE)



Elicits immune responses to VZV 1

Enhances the immune response to the vaccine antigen 1

  • A major glycoprotein from VZV
  • Unable to replicate
  • Induces local and transient activation of the innate immune response
  • Facilitates the recruitment and activation of antigen-presenting cells

SHINGRIX is designed to help induce antigen-specific immune responses in individuals with pre-existing immunity against the varicella zoster virus (VZV) 1

* Clinical significance has not been established.


  1. SHINGRIX Product Monograph. GlaxoSmithKline Inc., June 3, 2020.