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Invasive Pneumococcal Disease 1

  • IPD is a severe illness that occurs when bacteria invade normally sterile sites, such as the bloodstream or central nervous system.1
  • S. pneumoniae is the primary cause of IPD, which manifests as bacteraemia, bacteraemic pneumonia and meningitis.2
  • IPD can result in serious morbidity and mortality, particularly in children, even in developed countries with high standards of healthcare.2
  • In Canada, overall incidence of IPD in combined age groups has remained steady at approximately 9.0 cases per 100 000 since 2013.3
  • The highest rates of IPD in children occur in infants <1 year of age at 15.51 per 100,000 in 2016.3

Synflorix is not indicated to reduce the morbidity or mortality associated with IPD.


  1. Government of Canada. Canadian Immunization Guide: Part 4. Available at: Accessed July 24, 2018.
  2. Synflorix Product Monograph. GlaxoSmithKline Inc. August 31, 2018.
  3. Government of Canada. Notifiable diseases on-line: Invasive pneumococcal disease. Available at: Accessed July 24, 2018.