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Duac is a combination of clindamycin and benzoyl peroxide with dual antibacterial and anti-inflammatory effects 1

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Benzoyl peroxide (BPO) generates free radicals, which in combination with clindamycin (CDP) results in a synergism contributing to their complementary effects on acne 2 3

    • Duac vehicle gel contains hydrating excipients (glycerine and dimethicone) with humectant and emollient activities to help reduce skin dryness 4

    Duac 3% contains 1.25 times more glycerol and 10 times more dimeticone than Duac 5% for patients who require added moisturiser 6 7

  • The inclusion of benzoyl peroxide in Duac reduces the potential for the emergence of organisms resistant to clindamycin 1

    • Antibiotics kill susceptible bacteria and the addition of BPO destroys resistant strains, reducing their proliferation 8

    EDF Guideline recommendations for reducing antibiotic resistance 9

    The use of topical and systemic antibiotics should be optimized by using appropriate combinations for a predefined duration, in order to reduce the development of antibiotic resistance.9


  1. Duac 5% Summary of Product Characteristics, January 2015.
  2. Burkhart CG, Burkhart CN. Br J Dermatol 2008;159(2):480–481.
  3. Lookingbill DP et al. J Am Acad Dermatol 1997;37:590–595.
  4. Dhawan SS. Cutis 2009;83:265–272.
  5. Draelos ZD. Plast Reconstr Surg 2010;125(2):719–724.
  6. Data on File: 2016N276844_00; Glycerol and Dimeticone Content of Clindamycin 1% Benzoyl Peroxide 3% Gel, GlaxoSmithKline, March 2016.
  7. Data on File: 2016N276774_00; Glycerol and Dimeticone Content of Clindamycin 1% Benzoyl Peroxide 5% Gel, GlaxoSmithKline, March 2016.
  8. Burkhart CN et al. Skin Pharmacol Appl Skin Physiol 2000;13:292–296.
  9. Nast A et al. European Dermatology Forum. S3-Guideline for the treatment of acne (Update 2016). Available at: (Accessed February 2020)

Duac is a registered trademark of the GlaxoSmithKline group of companies.