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BLENREP dosing & administration

For Great Britain (GB) healthcare professionals only - BLENREP is not available in Northern Ireland (NI).

BLENREP has a conditional marketing authorisation.

BLENREP offers a BCMA-targeted therapy to your 5L+ patients with triple- class refractory myeloma, as a monotherapy in the outpatient setting*1

BLENREP is only available via the private market.

Table of contents

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BLENREP dosing regimen

LEARN MORE HERE
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Dose delays and modifications

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Off-the-shelf availability1

Patients will be able to start a BCMA-targeted treatment on its own with no requirement for premedication. A routine eye exam is needed prior to receiving BLENREP.

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Outpatient administration1

BLENREP is administered in an outpatient setting as an intravenous infusion over a minimum of 30 minutes, once every 3 weeks.

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No steroid premedication1

No steroids, like dexamethasone, are required prior to starting treatment with BLENREP.

BLENREP must be reconstituted and diluted by a healthcare professional prior to administration as an intravenous infusion.1

The recommended dose of BLENREP is:1

Infographic outlining the dosing regimen for BLENREP ▼ (belantamab mafodotin)

Treatment should be continued until disease progression or unacceptable toxicity.1

Dig deeper into BLENREP with our resources library

VIEW RESOURCES

Collaborate with eye care professionals* to monitor for eye-related side effects1

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*An eye care professional can be an ophthalmologist or optometrist.
Refer to the SmPC for more information.

BLENREP AEs may be managed through dose delays and modifications in some patients, whilst 12% of patients (n=11/95) discontinued treatment due to all AEs.3

In line with the SmPC, some patients may need to discontinue treatment for severe adverse events.1

Learn more about how to manage side effects with dose modifications, so you can aim to keep your patients on treatment.

LEARN MORE ABOUT DOSE MODIFICATIONS

Find out more about what BLENREP can offer your patients

About BLENREP

Understand how BLENREP works in multiple myeloma

Efficacy

Learn more about the efficacy of BLENREP

Safety

Discover the safety outcomes for BLENREP

BLENREP is indicated as monotherapy for the treatment of multiple myeloma in adult patients, who have received at least four prior therapies and whose disease is refractory to at least one proteasome inhibitor, one immunomodulatory agent, and an anti-CD38 monoclonal antibody, and who have demonstrated disease progression on the last therapy.1

Prescribing information can be found at the top of this webpage, or here.

Abbreviations

AE, adverse event; BCMA, B cell maturation antigen; BCVA, best corrected visual acuity; SmPC, Summary of Product Characteristics.

References

  1. BLENREP Summary of Product Characteristics.
  2. Ramasamy, K et al. Poster presented at the British Society of Haematology (BSH) on the 63rd Annual Scientific Meeting, 23-25 April 2023, ICC in Birmingham
  3. Lonial S, et al. Cancer. 2021;127(22):4198–4212.

▼This medicine is subject to additional monitoring. This will allow quick identification of new safety information.

Adverse events should be reported. Reporting forms and information can be found at https://yellowcard.mhra.gov.uk/ or search for MHRA Yellowcard in the Google Play or Apple App store. Adverse events should also be reported to GlaxoSmithKline on 0800 221 441 or email us on UKSafety@gsk.com.

© 2022 GSK Group of Companies or its licensor. Trademarks are the property of their respective owners.

February 2024 | PM-GB-BLM-WCNT-220006 (V5.0)