~50% of high-grade serous ovarian tumours are HRd4,5
~25% are BRCAmut4,5
- BRCA1 and BRCA2 produce proteins essential for repairing DNA damage via the HR pathway5
- Mutations in BRCA1/2 correlate with an HRd status5
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ZEJULA works by inhibiting PARP to prevent the repair of damaged DNA1
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June 2023 | PM-GB-NRP-WCNT-220018 (V1.0)