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COMPARATIVE STUDY OF DOVATO vs TAF-CONTAINING REGIMENS IN MORE THAN 700 VIROLOGICALLY SUPPRESSED PATIENTS
Phase III, Randomised, Multicentre, Parallel-Group, Non-Inferiority Switch Study 1
CONFIDENCE WITH POWERFUL EFFICACY MAINTAINED AT WEEK 48
No Increased Risk of Virological Failure vs TAF-Containing Regimens 1‡
ITT–E Snapshot analysis.
Adapted from van Wyk et al, 2019. 1
REASSURANCE WITH A HIGH BARRIER TO RESISTANCE UP TO 48 WEEKS
§Patients met confirmed virological withdrawal criteria if they had 1 assessment with HIV-1 RNA ≥200 copies/mL after Day 1 with an immediately prior HIV-1 RNA ≥50 copies/mL
References:
- van Wyk J, Ajana F, Bisshop F, et al. Switching to DTG/3TC fixed-dose combination (FDC) is non-inferior to continuing a TAF-based regimen in maintaining virologic suppression through 48 weeks (TANGO study). Presented at: International AIDS Conference; July 21-24, 2019; Mexico City. Slides WEAB0403LB.
- Dovato Summary of Product Characteristics. Available at: https://www.medicines.ie/medicines/dovato-50-mg-300-mg-film-coated-tablets-34871/smpc. Last Accessed, June 2020.
Adverse events should be reported to the Health Products Regulatory Authority (HPRA) using an Adverse Reaction Report Form obtained either from the HPRA or electronically via the website at www.hpra.ie. Adverse reactions can also be reported to the HPRA by calling (01) 6764971. Adverse events should also be reported to GlaxoSmithKline on 1800 244 255.
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