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Dovato is indicated for the treatment of HIV-1 in adults and adolescents above 12 years weighing at least 40 kg, with no known or suspected resistance to the integrase inhibitor class, or lamivudine. 3

Dovato Recommended in Treatment Guidelines

EACS Guidelines

Dovato is recommended as an initial regimen for treatment naïve patients and as a switch strategy for virologically supressed patients 1

Requirements for treatment naïve patients:

  • HBsAg negative 
  • HIV Viral load <500,000 copies/ml
  • CD4 count >200 cells/µL
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DHHS Guidelines

Dovato is recommended as an initial regimen for most PLHIV (AI)*+ and as a good option for virologically suppressed patients who have no evidence of resistance to either drug 2

Exclusions for treatment naïve patients:

  • HIV viral load of >500,000 copies/ml
  • HBV co-infection
  • Where ART is to be started before the results of HIV genotype resistance testing for reverse transcriptase or HBV testing are available
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References:

  1. European AIDS Clinical Society Guidelines Version 10.0. November 2019. https://www.eacsociety.org/files/2019_guidelines-10.0_final.pdf. Accessed April 2020.
  2. Department of Health and Human Services. Guidelines for the use of antiretroviral agents in adults and adolescents with HIV https://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf. Accessed April 2020.
  3. DOVATO Summary of Product Characteristics. https://www.medicines.ie/medicines/dovato-50-mg-300-mg-film-coated-tablets-34871/smpc. Last accessed: June 2020.

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