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  • Efficacy

    POWERFUL EFFICACY IN TREATMENT-NAÏVE ADULT

    RAPID, POWERFUL AND DURABLE EFFICACY

    DOVATO Non-Inferior to DTG + TDF/FTC at 96 Weeks 1

    POWERFUL EFFICACY IN TREATMENT-NAÏVE ADULT

    Efficacy graph

    ITT–E Snapshot analysis.

    Adapted from Cahn et al, 2019. 1

  • Baseline Viral Load Strata

    POWERFUL SUPPRESSION ACROSS VIRAL LOAD STRATA

    Virological Outcomes by Baseline Viral Load at 96 Weeks (ITT–E Pooled Analysis) 1

    Baseline viral load strata

    DTG 50 mg + 3TC 300 mg used in the GEMINI studies.

    Adapted from Cahn et al, 2019. 1

  • Viral Blips

    ROBUST VIROLOGICAL CONTROL COMPARABLE TO DTG + TDF/FTC

    Similar Viral Blip* Frequencies Across Both Arms Through Week 48 2

    Viral blips

    Adapted from Cahn et al, 2019. 1

    • Proportion of patients with viral blips was similar across both arms: 12% (83/716) in DOVATO vs 13% (93/717) in DTG + TDF/FTC 2

    DTG 50 mg + 3TC 300 mg used in the GEMINI studies.

    *A viral blip is a transient increase in viral load ≥50 copies/mL to <200 copies/mL bounded by viral loads <50 copies/mL. Note: individual patients could have had ≥1 blip.

Virological Outcomes by Baseline CD4+ T-cell Count Strata at 96 Weeks 1

  • ITT-E: >200 cells/mm2 DOVATO 88% (573/653) vs DTG + TDF/FTC 90% (594/662) 
  • When treatment-related discontinuation=failure (TRDF)* analysis is applied: >200 cells/mm2  DOVATO 97% (633/653) vs DTG + TDF/FTC 96% (638/662) 
  • ITT-E: ≤200 cells/mm3 DOVATO 68% (43/63) vs DTG + TDF/FTC 87% (48/55) 
  • When TRDF analysis is applied: ≤200 cells/mm3 DOVATO 94% (59/63) vs DTG + TDF/FTC 96% (53/55)

References:

  1. Cahn P, Sierra Madero J, Arribas J, et al. Durable efficacy of dolutegravir (DTG) plus lamivudine (3TC) in antiretroviral treatment-naïve adults with HIV-1 infections: 96-week results from the GEMINI studies, Presented at: International AIDS Conference; July 21-24, 2019; Mexico City, Mexico, Slides WEAB0404LB.
  2. Underwood M, Wang R, Horton J, et al. Dolutegravir (DTG) plus lamivudine (3TC) versus DTG plus tenofovir/emtricitabine (TDF/FTC) fixed-dose combination in the GEMINI studies-viral load rebound including 'blips' through 48 weeks. Presented at: International AIDS Conference ; July 21-24, 2019; Mexico City, Mexico. Poster MOPEB231.
  3. Dovato Summary of Product Characteristics. Available at www.medicines.ie. Last Accessed June 2020

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