- Sebum is produced by the pilosebaceous glands, which are predominantly found on the face, back and chest
- This may be due to an increased response to normal levels of androgens
- Abnormal proliferation and differentiation of keratinocytes leads to comedone formation
- Sebum and comedone formation alters the micro environment in the pilosebaceous duct, which leads to colonisation of the duct
- Acne lesions begin with an initial inflammatory event, triggered by an infiltration of inflammatory cells
Stages of acne 4
Stages of acne. (A) Normal follicle; (B) open comedone (blackhead); (C) closed comedone (whitehead); (D) papule; (E) pustule.
Common causes of acne 2
- Increased androgens/sebum production in puberty
- Resistance bacteria
- Use of cosmetics
- Stress (increased androgen production)
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