You are now leaving GSK’s website

This link will take you to a non-GSK website. GSK does not recommend, endorse or accept liability for sites controlled by third-parties.


Go back

AIDS Conference 2018 - Durable Suppression 2 Years After Switch to DTG + RPV 2-Drug Regimen: SWORD Studies 1

Download the Sword 100 Week Slide Set     Access the SWORD Clinical Paper

Two Large Studies with Over 1,000 Adults

Go To Top Close

Study design: Two identical, open-label Phase III studies 2

SWORD Study Design

JULUCA – Durable Virological Suppression Up To Week 100

Snapshot virological outcomes at Week 48 and Week 100 (SWORD-1 & SWORD-2 pooled) 12

Snapshot virological outcomes at Week 48 and Week 100

* Out to week 100, 5% discontinued due to adverse events (snapshot analysis). 1

JULUCA – High Barrier to Resistance Up to Week 100

Juluca 0 Failures
  • Through Week 100, there was a low number of confirmed virological withdrawals (CVWs) across study populations (1%; 10/990) 1
  • CVWs with resistance-associated treatment-emergent mutations were low across both groups and detected in 3 participants, all receiving DTG + RPV (0.3%; 3/990) 1
  • Three participants on DTG + RPV were identified as having ≥1 NNRTI resistance-associated mutation (1 [E138E/A]; 2 [K101K/E]; 3 [K101E, E138A and M230M/L]) 1

JULUCA – 2 Agents with the Tolerability You Expect

SWORD 100 Week Data Results
  • At Week 48, most common drug-related AEs were headache (JULUCA: 2% vs continued 3-drug regimen: 0%) and diarrhoea (JULUCA: 2% vs continued 3-drug regimen: <1%) 2 
  • At Week 100, most common drug-related AEs occurring in ≥ 2% participants were headache (2%) and nausea (2%), all being Grade 1 1
  • Cumulative adverse events in the early switch arm up to Week 100: 7% (3% from Day 1 to Week 48) 1
  • Cumulative AEs reported in the early-switch group were consistent with the respective labels 1

JULUCA is indicated for HIV-1 virologically suppressed adults on a stable regimen for at least 6 months with no history of virological failure and no known or suspected resistance to any NNRTI or INI.


DTG 50 mg + RPV 25 mg (bioequivalent to JULUCA) used in SWORD studies.
Reported by 2% or more of participants in either group. 2


  1. Aboud M et al. Presented at: International AIDS Conference; July 23-27, 2018; Amsterdam, Netherlands. Poster THPEB047
  2. Llibre JM et al. Lancet. 2018;391:839-849.
  3. Mills A et al. Lancet Infect Dis. 2016;16:43-52.

Adverse events should be reported directly to the HPRA; Freepost, Pharmacovigilance Section, Health Products Regulatory Authority, Earlsfort Terrace, Dublin 2, Tel: +353 1 676 4971 Adverse events should also be reported to GlaxoSmithKline on 1800 244 255.

▼ These medicinal products are subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions.

Trade marks are owned by or licensed to the ViiV Healthcare group of companies.