You are now leaving GSK Malta Health Portal

You are about to leave a GSK Website. By clicking this link, you will be taken to an external website that is not owned or controlled by GSK, and GSK is not responsible for the content provided on this site. If you do not wish to leave this website, click on “Go Back” below:


Go back

Date of preparation: March 2018

How long do associated symptoms last?  

Most people infected with the virus do not develop a clinically recognised illness, although the symptoms vary depending on the severity of disease and the immune system of the individual infected. 12However, 80–90% of infants infected during the first year of life develop chronic infections. 1

Short-term symptoms (acute) can last several weeks and can include: 1

  • Yellowing of the skin and eyes (jaundice)
  • Dark-coloured urine
  • Extreme fatigue
  • Nausea
  • Vomiting
  • Abdominal pain

If the disease becomes life-long, symptoms can also include: 1

  • Cirrhosis of the liver
  • Liver cancer

How do Hepatitis B complications arise?

For a small proportion of people, acute infections with hepatitis B can be severe and lead to death. 3The most serious complications of the viral infection, including chronic hepatitis, cirrhosis, liver failure, and liver cancer, occur in people with chronic infection. 3

80–90% of infants infected during the first year of life develop chronic infections. 3


  1. WHO. Hepatitis B fact sheet. 2015. Available at: Last accessed June 2015.
  2. WHO. Global Alert and Response (GAR): Hepatitis B index 3. 2015. Available from: Last accessed June 2015.
  3. WHO. Hepatitis B - The disease. 2014. Available at: Last accessed June 2015.

Twinrix is a registered trade mark of the GlaxoSmithKline group of companies