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Make a strong start in the management of bacterial infections

Augmentin has a notably broad spectrum of activity against the commonly occurring bacterial pathogens in general practice and hospital.1

Indication

AUGMENTIN is an antibiotic agent with a notably broad of activity against the commonly occurring bacterial pathogens in general practice and hospital.1-3.

The beta-lactamase inhibitory action of clavulanate extends the spectrum of amoxicillin to embrace a wider range of organisms, including many resistant to other beta-lactam antibiotics.1-3.

Augmentin 625mg and 1g tablets, as well as Augmentin ES, 228mg and 457mg suspension is indicated for the treatment of infections caused by susceptible bacteria, including:1-3

  • Upper respiratory tract including ear, nose and throat infections (e.g. tonsillitis, sinusitis and otitis media, including recurrent or persistent acute otitis media caused by certain bacteria in paediatric patients; Augmentin ES)
  • Lower respiratory tract infections acute of chronic lobar and bronchopneumonia
  • Genito-urinary tract infections (e.g. cystitis, urethritis and pyelonephritis)
  • Skin and soft-tissue infections
  • Bone and joint infections (e.g. osteomyelitis)
  • Dental infections (e.g. dentoalveolar abscess, severe dental abscess with spreading cellulitis)
  • Other infections (e.g. intra-abdominal sepsis, septic abortion and puerperal sepsis)

Understand more about the quality of Clavulanic acid

Safety Information for Augmentin

CONTRAINDICATIONS: Augmentin is contra-indicated in patients with a history of hypersensitivity to beta-lactams e.g. penicillin's and cephalosporins

WARNINGS AND PRECAUTIONS: Before initiating therapy with AUGMENTIN careful enquiry should be made concerning previous hypersensitivity reactions to penicillin, cephalosporins, or other allergens. AUGMENTIN should be avoided if infectious mononucleosis is suspected since the occurrence of a morbilliform rash has been associated with this condition following the use of amoxicillin, Prolonged use may also occasionally result in overgrowth of non-susceptible organisms.

Pseudomembranous colitis has been reported with the use of antibiotics and ay range in severity from mild to life-threatening.

Therefore, it is important to consider its diagnosis in patients who develop diarrhoea during or after antibiotic use, If prolonged or significant diarrhoea occurs or the patient experiences abdominal craps, treatment should be discontinued immediately, and the patient investigated further. Concomitant use of probenecid is not recommended. Probenecid decreases the renal tubular secretion of amoxicillin.

Concomitant use with AUGMENTIN may result in increased and prolonged blood levels of amoxicillin but not clavulanate, Concomitant use of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions. There are no data on the concomitant use of AUGMENTIN and allopurinol.

In common with other antibiotics, AUGMENTIN may affect the gut flora leading to lower oestrogen reabsorption and reduced efficaact of combined oral contraceptives.

ADVERSE EVENTS: Common: Mucocutaneous candidiasis, Nausea, Vomiting and diarrhoea.

Learn more about Augmentin

Important product Information

Augmentin prescribing information for tablets

Augmentin Suspension prescribing information.

Augmentin ES prescribing information

References

  1. Augmentin BD Tablets Prescribing Information, GDS26/IPI13, June 2019.
  2. Augmentin Suspension Prescribing Information, GDS26/IPI14, June 2019.
  3. Augmentin ES Prescribing Information, GDS24/IPI11, June 2019.

PM-NG-ACA-WCNT-220003 Date of Preparation: May 2022