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Efficacy in generalised epilepsy

Keppra significantly reduced the percentage of seizure days/week vs placebo in patients with adolescent-onset generalised epilepsy as an adjunct1

Median percentage reduction from baseline in seizure days/week over the treatment period (up-titration and maintenance)1

Supplementary analysis of two double-blind, placebo-controlled trials. Patients received LEV (target dose: adults 3000 mg/day; children 60 mg/kg/day) or placebo for 16–24 weeks (including 4-week up-titration) in addition to 1–2 anti-epileptic drugs. Patients across the two studies were aged 4–65 years.1

The same results were first published in Rosenfeld WE, et al. Epilepsy Research 2009;85:72–80. The graph has been independently created by GSK from the original data.

Safety information: The most frequent adverse events reported in these studies on levetiracetam vs placebo were headache (16.8% vs 14.8%) and somnolence  (9.7% vs 3.9%).1

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Abbreviations

LEV: levetiracetam; SD: study design.

References

  1. Rosenfeld WE, et al. Epilepsy Research 2009;85:72–80.

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PM-NG-LVT-WCNT-200004 Date of preparation: November 2020.