You are now leaving GSK’s website

You are now leaving a GSK Website. By clicking this link, you will be taken to a website that is not owned or controlled by GSK, and GSK is not responsible for the content provided on that site

Continue

Go back

Psychiatric side effects associated with AED usage
 

  • Among paediatric and adult patients with epilepsy, about 30% (newly diagnosed cases) to 50% (resistant cases) suffer from complex psychiatric, behavioural and other symptoms1
  • Patients with history of a psychiatric condition, absence seizures, intractable epilepsy, or frontal lobe epilepsy are more likely to develop PBSE2,3


Psychiatric side effects associated with levetiracetam
 

  • Common psychiatric (≥1/100 to <1/10) AEs associated with LEV are depression, hostility/aggression, anxiety, insomnia, nervousness / irritability4
  • Psychiatric behavioural side effects (PBSE) with LEV are more common in children than adults4
  • Most of the behavioural/psychiatric AEs observed with LEV are mild to moderate in severity5
  • Very low number of patients discontinued LEV in both randomised controlled trials and observational studies5
  • Slow titration of LEV is advisable in patients with past psychiatric history6

Summary of aggression-related behavior incidence from AED labels

AEDs are listed in alphabetical order. 
Adverse drug reactions (ADRs) frequencies are defined as: 
Very common ≥1/10; Common ≥1/100 to <1/10; Uncommon ≥1/1000 to <1/100; 
Rare ≥1/10000 to <1/1000; Very rare <1/10000; UNK: Not known (cannot be estimated from the available data). For additional details about LEV safety and tolerability please refer to Keppra Prescribing Information.

! – prevalence common in children; * - as an adjuvant; PBO: placebo

Warnings related to psychiatric adverse events associated with levetiracetam:* Levetiracetam may cause psychotic symptoms and behavioural abnormalities, including irritability and aggressiveness. Patients treated with levetiracetam should be monitored for developing psychiatric signs suggesting important mood and/or personality changes. If such behaviours are noticed, treatment adaptation or gradual discontinuation should be considered.

Read more about Keppra

Abbreviations

AE: adverse event; AED: anti-epileptic drug; CBZ: carbamazepine; ESL: eslicarbazepine; ETX: ethosuximide; FLB: felbamate; GBP: gabapentin; LAC: lacosamide; LEV: levetiracetam; LTG: lamotrigine; OXC: oxcarbazepine; PER: perampanel; PGB, pregabalin; PHB: phenobarbital; STR: stiripentol; TGB: tiagabine; TOP: topiramate; VAL: valproate; VGB: vigabatrin; ZNS: zonisamide.

References

  1. Brodie M, et al. Pharmacol Rev 2016;68:563-602.
  2. Stephen LJ, et al. Epilepsy Behav 2017;71:73–78.
  3. Chen B, et al. Eur J Ped Neurol 2017;21: 441-9.
  4. Levetiracetam. Non Central Data Sheet Version Number: 10. Version Date: 6 January 2020.
  5. Halma E, et al. Seizure 2014;23:685–691.
  6. White JR, et al. Neurology 2003;61:1218–1221.

GSK shall not be liable for any damages, claims, liabilities, costs or obligations arising from the use or misuse of information provided herein. 
For safety information on GSK products or to report an Adverse Event, please contact the toll free line 
0800 CALL GSK (0800 2255 475) or email aereporting.ng@gsk.com 
Full prescribing information is available on request on www.gskpro.com
Please note that it may take up to 10 days to process your request. If you need further assistance contact 
GSK House, 1 Industrial Avenue llupeju, Lagos or via email at customercare_ph_nigeria@gsk.com
GlaxoSmithKline Pharmaceutical Nigeria Ltd, 1 Industrial Avenue, llupeju, Lagos 234-1-271 1000 
©2020 GSK group of companies or its licensor 
Trade marks are owned by or licensed to the GSK group of companies

Keppra is a registered trademark of the GlaxoSmithKline group of companies

PM-NG-LVT-WCNT-200004 Date of preparation: November 2020.