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Short titration time


Keppra needs minimal dose titration to reach a therapeutic dose, compared with other AEDs1,2

Approximate titration times of common AEDS*

* Values are approximate and indicative only. Some patients may need slower titration and larger doses while others may need smaller doses and can tolerate faster titration. The same results were first published in Panayiotopoulos CP. Oxfordshire (UK): Bladon Medical Publishing; 2005. Chapter 4 Principles of Therapy in Epilepsies. Available at: https://www.ncbi.nlm.nih.gov/books/NBK2606/. Accessed March 2020. This figure has been independently created by GSK from the original data.

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Abbreviations

AED: anti-epileptic drug; CBZ: carbamazepine; CLON: clonazepam; CLZ: clobazam; ETH: ethosuximide; GBP: gabapentin; LEV: levetiracetam; LTG: lamotrigine; OXC: oxcarbazepine; PB: phenobarbital; PHT: phenytoin; TOP: topiramate; TIG: tiagabine; VPA: valproate; ZNS: zonisamide.

References

  1. Levetiracetam. Non Central Data Sheet Version Number: 10. Version Date: 6 January 2020.
  2. Panayiotopoulos CP. Oxfordshire (UK): Bladon Medical Publishing; 2005. Chapter 4 Principles of Therapy in Epilepsies. Available at: https://www.ncbi.nlm.nih.gov/books/NBK2606/. Accessed April 2020.

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PM-NG-LVT-WCNT-200004 Date of preparation: November 2020.