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CHOOSE NUCALA FOR REAL-LIFE RESULTS
NUCALA is indicated for the add-on maintenance treatment of patients 6 years and older with severe asthma with an eosinophilic phenotype. NUCALA is not indicated for the relief of acute bronchospasm or status asthmaticus.
long-term results
The only anti-interleukin 5 (IL-5) with a
4.5-year
open-label study that evaluated safety and efficacy3
- †REALITI-A2: Interim analysis of a prospective observational cohort study of 368 patients. Exacerbations: 4.63/year at baseline vs 1.43/year at 12 months. OCS: 34% (43/125) during Weeks 53-56 of patients on maintenance OCS at baseline. Results are descriptive. Study Limitations: May not reflect final results. Real-world studies are designed to evaluate associations among variables and not to definitively establish causality. Limitations important when interpreting results: lack of comparator arm; differences in patient populations and data collection vs randomized controlled trials.
- *MENSA1: 32-week placebo-controlled study in 576 patients. NUCALA: 0.83/year, placebo: 1.74/year; P<0.001.
- ‡Following the optimization phase in a controlled OCS reduction trial, 14% (10/69) of patients treated with NUCALA vs 8% (5/66) treated with placebo eliminated daily OCS use while maintaining asthma control (See Clinical Efficacy).5
What does a NUCALA patient look like?
REFERENCES:
- Ortega HG, Liu MC, Pavord ID, et al. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med. 2014;371(13):1198-1207.
- Data on file, GSK.
- Khatri S, Moore W, Gibson PG, et al. Assessment of the long-term safety of mepolizumab and durability of clinical response in patients with severe eosinophilic asthma. J Allergy Clin Immunol. 2019;143(5):1742-1751.
- Pavord ID, Korn S, Howarth P, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012;380:651-659.
- Bel EH, Wenzel SE, Thompson PJ, et al. Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med. 2014;371(13):1189-1197.