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DOSING & ADMINISTRATION

POWER TO CHOOSE

The only asthma biologic to offer:

Once-monthly dosing

(every 4 weeks)

+

No loading dose

+

Fixed-dose

(independent of weight)

Lyophilized Powder

Administering NUCALA In Office: Severe Asthma

Patients aged 6 to 11 years

Recommended dose is 40 mg

Administer 0.4 mL of the reconstituted solution

Patients aged ≥12 years

Recommended dose is 100 mg

Administer 1 mL of the reconstituted solution

Learn more about use in pediatric patients (aged 6-11 years)

Reconstituting NUCALA

NUCALA should be reconstituted by a healthcare professional. The reconstituted solution will contain a concentration of 100 mg/mL mepolizumab. Do not mix with other medications.

Ensure you have everything you need to reconstitute NUCALA:

  • 1 vial of NUCALA
  • Sterile water (1.2 mL) for Injection, USP
  • A syringe (preferably 2 to 3 mL)
  • A needle (preferably 21 gauge)

Withdraw 1.2 mL of Sterile Water for Injection into the syringe.

Direct the stream of Sterile Water for Injection vertically onto the center of the lyophilized cake.

Gently swirl the vial for 10 seconds with circular motion at 15-second intervals until the powder is dissolved.*

DO NOT SHAKE the reconstituted solution during the procedure because this may lead to product foaming or precipitation.

INSPECT the reconstituted solution. If particulate matter remains in the solution or if it appears cloudy or milky, the solution must not be administered.

Manual reconstitution is typically complete ~5 minutes after the water
has been added.

  • *If a mechanical reconstitution device (swirler) is used to reconstitute NUCALA, swirl at 450 rpm for no longer than 10 minutes. Alternatively, swirling at 1000 rpm for no longer than 5 minutes is acceptable.
  • The solution should be clear to opalescent, and colorless to pale yellow or pale brown, essentially particle free. Small air bubbles, however, are expected and acceptable.

Storage

If the reconstituted solution is not used immediately:

  • Store below 30°C (86°F)
    • Does not require refrigeration if stored below 30°C (86°F)
  • Do not freeze
  • Discard if not used within 8 hours of reconstitution

Storage

If the reconstituted solution is not used immediately:

  • Store below 30°C (86°F)
    • Does not require refrigeration if stored below 30°C (86°F)
  • Do not freeze
  • Discard if not used within 8 hours of reconstitution

Manual and mechanical
reconstitution instructions for NUCALA

MANUAL RECONSTITUTION INSTRUCTIONS

This video includes instructions for the manual reconstitution of one vial of NUCALA. See also Section 2 of the Prescribing Information.
 

MECHANICAL RECONSTITUTION INSTRUCTIONS

This video includes instructions for the mechanical reconstitution of one vial of NUCALA. See also Section 2 of the Prescribing Information.