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PEDIATRIC USE (AGES 6-11)

The FIRST and ONLY severe eosinophilic asthma biologic indicated down to age 6

Identifying Appropriate Pediatric Patients

Patients aged 6 to 11 years with severe asthma and:
  • Medium- to high-dose* ICS, plus additional controller 
  • 2+ exacerbations in the previous 12 months
  • Baseline blood eosinophils ≥150 cells/μL, which is predictive of efficacy for NUCALA

The safety and efficacy of NUCALA for severe eosinophilic asthma have been established in patients aged 6 years and older.

*Medium- to high-dose ICS defined as >200 μg/day fluticasone propionate dry powder inhaler or equivalent daily.1

Exacerbations were defined as the worsening of asthma that required use of oral/systemic corticosteroids and/or hospitalization and/or emergency department visits.1

Image is for illustrative purposes only.

Dosing

The recommended dose of NUCALA in children aged 6 to 11 years is 40-mg subcutaneous (SC) administered once every 4 weeks. 

Administration of 40-mg dose

NUCALA lyophilized powder should be reconstituted and administered by a healthcare professional. Follow the instructions in the Prescribing Information for reconstitution. 

Remove 0.4 mL of reconstituted NUCALA (equivalent to 40 mg of mepolizumab) and administer SC injection into the upper arm, thigh, or abdomen. In line with clinical practice, monitoring of patients after administration of biologic agents is recommended.

Each vial of NUCALA contains 100 mg/mL of reconstituted solution. Any residual should be discarded. Each vial should be used for a single patient. 

 

 

Dosing

The recommended dose of NUCALA in children aged 6 to 11 years is 40 mg subcutaneous (SC), administered once every 4 weeks. 

Administration of 40-mg dose

NUCALA lyophilized powder should be reconstituted and administered by a healthcare professional. Follow the instructions in the Prescribing Information for reconstitution. 

Remove 0.4 mL of reconstituted NUCALA (equivalent to 40 mg of mepolizumab) and administer SC injection into the upper arm, thigh, or abdomen. In line with clinical practice, monitoring of patients after administration of biologic agents is recommended.

Each vial of NUCALA contains 100 mg/mL of reconstituted solution. Any residual should be discarded. Each vial should be used for a single patient. 

REFERENCE:

  1. Gupta A, Manasoori I, Geng B, et al. Long-term safety and pharmacodynamics of mepolizumab in children with severe asthma with an eosinophilic phenotype. J Allergy Clin Immunol. 2019:144(5):1336-1342.e7.