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THE NUCALA PATIENT

Patients with severe eosinophilic asthma are complex

If you have patients like these, NUCALA may help

FREQUENT EXACERBATIONS AND COMORBID ATOPIC STATUS

37-year-old male

FROM AN EXPERT

See how NUCALA can help in this patient type.

 

Medical History and Report

  • Asthma diagnosis at age 16
  • Atopic status: positive (prior SCIT)
  • 3 exacerbations in the past year (outpatient, treated with high-dose OCS)
  • Currently taking high-dose ICS/LABA + LAMA + LTRA, nasal steroid, albuterol as needed
  • Allergic rhinitis, chronic sinus congestion
  • Persistent dyspnea, intermittent wheezing, frequent awakenings, frequent use of rescue inhaler
  • Symptoms limit exercise and social activity

Spirometry

  • FEV1: 64% predicted
  • FEV1/FVC ratio: 0.71

Laboratory Assessment

  • CBC with differential
    • Eosinophil count: 376 cells/µL
  •  Total IgE: 392 kU/L

CBC=complete blood count; FEV1=forced expiratory volume in 1 second; FVC=forced vital capacity; ICS=inhaled corticosteroid; IgE=immunoglobulin E; LABA=long-acting beta2-adrenergic agonist; LAMA=long-acting muscarinic antagonist; LTRA=leukotriene receptor antagonist; SCIT=subcutaneous immunotherapy.

FREQUENT EXACERBATIONS AND COMORBID NASAL POLYPS

43-year-old male

FROM AN EXPERT

See how NUCALA can help in this patient type.

 

Medical History and Report

  • Asthma diagnosis at age 20
  • Presence of nasal polyps
  • History of SCIT
  • 2 exacerbations in the past year, including a hospitalization
  • Currently taking high-dose ICS/LABA (13 years) + LTRA (6 years), nasal corticosteroid spray, albuterol as needed
  • Persistent dyspnea, interferes with life; chronic sinus congestion

Spirometry

  • FEV1: 66% predicted
  • FEV1/FVC ratio: 0.69

Laboratory Assessment

  • CBC with differential
    • Eosinophil count: 324 cells/µL
  • Total IgE: 352 kU/L

OCS DEPENDENT

47-year-old female

FROM AN EXPERT

See how NUCALA can help in this patient type.

 

Medical History and Report

  • Asthma diagnosis at age 29
  • 2 exacerbations treated with OCS in the past year; 1 outpatient, 1 ED visit
  • Currently taking OCS 12.5 mg (daily, 9 months), high-dose ICS/LABA + LTRA, albuterol as needed
  • Daily cough/wheeze with mucus production
  • Symptoms often restrict daily activities and interfere with work
  • Weight gain of 15 lbs in the last 9 months

Spirometry

  • FEV1: 62% predicted
  • FEV1/FVC ratio: 0.70

Laboratory Assessment

  • CBC with differential
    • Eosinophil count: 190 cells/µL
    • Historical eosinophil count (1 year ago): 390 cells/µL
  • Total IgE: 102 kU/L

OCS=oral corticosteroids.

PEDIATRIC

10-year-old male

Medical History and Report

  • Asthma diagnosis at age 6
  • 2 exacerbations in the past year; 1 hospitalization in the past year
  • Currently taking high-dose ICS/LABA (3 years) + LAMA (2 years), nasal corticosteroid spray, albuterol as needed
  • Persistent dyspnea, intermittent wheezing, frequent use of rescue inhaler
  • Missed school due to asthma symptoms

Spirometry

  • FEV1: 64% predicted
  • FEV1/FVC ratio: 0.71

Laboratory Assessment

  • CBC with differential
    • Eosinophil count: 370 cells/µL
  • Total IgE: 148 kU/L