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Maternal Immunization offers passive immunity to the newborn via transplacental transfer of maternal
antibodies 1 2

Results from a prospective controlled cohort study showed that infants born to mothers vaccinated against pertussis had higher titers of anti-pertussis antibodies at birth, and during the first 2 months before their primary vaccine series, compared to infants of unvaccinated mothers 3

Infants born to vaccinated women had higher antibody GMCs against pertussis antigens at birth, and during the first 2 months of life, compared to infants of unvaccinated women 3

  • STUDY DESCRIPTION

    Maertens K, et al. Pertussis vaccination during pregnancy in Belgium: Results of a prospective controlled cohort study. Vaccine. 2016;34(1):142-150.

    • A prospective controlled cohort study was conducted by Maertens K, et al 3
    • These graphs show data comparing the antibody response of newborn and very young infants whose mothers had received the Tdap vaccination in pregnancy with those who had not 3
    • The left-hand graph shows the antibody response of newborns, with blood samples taken from the umbilical cord 3
    • The right-hand graph shows the antibody response of infants aged 2 months, before they had started their vaccination program 3
    • In both graphs, there is a significant difference in antibody response between the two
      groups 3
    • Infants born to vaccinated women had significantly higher geometric mean concentrations (GMC) at birth and during the first 2 months of life for all vaccine antigens compared to the offspring of unvaccinated women, thereby closing the susceptibility gap for pertussis in
      infants 3

References:

  1. Healy CM. Pertussis vaccination in pregnancy. Hum Vaccin Immunother. 2016;12(8):1972-1981.
  2. Gkentzi D, et al. Maternal vaccination against pertussis: a systematic review of the recent literature. Arch Dis Child Fetal Neonatal Ed. 2017;102:F456-F463.
  3. Maertens K, et al. Pertussis vaccination during pregnancy in Belgium: Results of a prospective controlled cohort study. Vaccine. 2016;34(1):142-150.