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Why molecules matter

Achieving asthma control is influenced by many factors including delivery of inhaled therapies to the lung.

The particle size* range of 1–5 μm is considered optimal for drug delivery to the small airways (<2000 μm).1–6

All particles in Relvar Ellipta* are within the optimal size range for the treatment of asthma.1,2,5–7

Relvar molecule size graphic Relvar molecule size graphic

There is no evidence that extrafine particles offer any additional clinically relevant benefits compared with standard ICS/LABA particle sizes.7

Relvar's ICS – selected for a longer duration of action vs both budesonide and beclomethasone†8–10

Molecule icon

Fluticasone furoate is longer acting and more targeted to the appropriate receptors, compared with both budesonide and beclomethasone (in vitro data)†8–10

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Footnotes

*Mass median aerodynamic diameter. Lung deposition data does not necessarily predict clinical effects.
In vitro data: clinical relevance is uncertain.

Abbreviations

AE, adverse event; ICS, inhaled corticosteroid; LABA, long-acting β2-agonist.

Relvar Safety Information11

Contraindications
Hypersensitivity to the active substances or to any of the excipients.

Undesirable effects
Very Common: Headache, Nasopharyngitis.

Common: Infections and infestations, Oropharyngeal pain, Sinusitis, Pharyngitis, Rhinitis, Cough, Dysphonia, Abdominal pain, Arthralgia, Back pain, Fractures, Muscle spasms and Pyrexia.

References
  1. GSK Data on File RF/FFT/0013/15(1);2018.
  2. Scichilone N, et al. J Asthma Allergy 2013;6:11–21.
  3. Scheuch G, et al. Adv Drug Del Rev 2006;58:996–1008.
  4. Gentile DA. Curr Opin Pharmacol 2010;10:260–265.
  5. Laube BL, et al. ERS Journal 2011;37:1308–1331.
  6. Zeidler MR, et al. Eur Respir J 2006;27:307–315.
  7. El Baou C, et al. BMC Pulm Med 2017;17:31.
  8. Daley-Yates P. Br J Clin Pharmacol 2015;80:372–380. 
  9. Rossios C, et al. Eur J Pharmacol 2011;670:244–251.
  10. Salter M, et al. Am J Physiol Lung Cell Mol Physiol 2007;293:L660–667. 
  11. Relvar Prescribing Information.

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For more information, please refer to the prescribing information or contact GlaxoSmithKline via gcc.medinfo@gsk.com
To report Adverse Event/s associated with the use of GSK product/s, please contact us via
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Department of Pharmacovigilance & Drug Information
Drug Safety Center
Ministry of Health, Sultanate of Oman
Phone Nos. 0096822357687 / 0096822357690
Fax: 0096822358489
Email: pharma-vigil@moh.gov.om
Website: https://moh.gov.om/en/

دائرة التيقظ و المعلومات الدوائية
مركز سلامة الدواء
وزارة الصحة, سلطنة عمان
هاتف: 0096822357687 / 0096822357690
0096822358489 :فاكس
pharma-vigil@moh.gov.om :البريد االكتروني
https://moh.gov.om/en/ : الموقع االكتروني

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PM-RCH-FFV-WCNT-250001 Date of preparation: July 2025