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Glossary (Created by GSK)

A

ABPA – allergic bronchopulmonary aspergillosis
ACE inhibitor – angiotensin-converting enzyme inhibitor
ACT – Asthma Control Test
ACQ – Asthma Control Questionnaire
ADA – anti-drug antibodies
ATAQ – Asthma Therapy Assessment Questionnaire
ATS – American Thoracic Society
AUC – area under the curve

B

BDI-II – Beck Depression Inventory-II
BMI – body mass index

C

CDR – complementarity-determining region
CFC MDI – chlorofluorocarbon metered dose inhaler
COPD – chronic obstructive pulmonary disease
CT-scan – computed-tomography scan

DPI – dry powder inhaler
DREAM – Dose Ranging Efficacy And Safety With Mepolizumab In Severe Asthma

E

ERS – European Respiratory Society

F

Fab – fragment antigen-binding
Fc – fragment crystallisation
FEV1 – forced expiratory volume in 1 second
FVC – forced vital capacity

GINA – Global Initiative in Asthma

HFA MDI – hydroflyoroalkane metered dose inhaler
HRQoL – health-related quality of life

ICS – inhaled corticosteroids
IgE – immunoglobulin E
IgG – immunoglobulin G
IL-5/4/13 – interleukin-5/4/13
ILC2 – innate lymphoid cells type 2
i.v. – intravenous

LABA – long-acting beta-adrenoceptor agonist
LTRA – leukotriene receptor antagonist

M

mAb – monoclonal antibody
MDI - metred dose inhaler
MENSA - Mepolizumab As Adjunctive Therapy In Patients With Severe Asthma
MHC – major histocompatibility class
MoA – mechanism of action

O

OCS – oral corticosteroids

PEF – peak expiratory flow

QoL – quality of life

SABA – short-acting beta-adrenoceptor agonist
SARP – Severe Asthma Research Programme
s.c. - subcutaneous
SGRQ – St George’s Respiratory Questionnaire
SIRIUS – Steroid Reduction With Mepolizumab Study

Th2 – T-helper cell type 2
TSLP – thymic stromal lymphopoietin
TENOR – The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens study

U-BIOPRED – Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes

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