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SHINGRIX mechanism of action

SHINGRIX IS DESIGNED TO INDUCE CELLULAR AND HUMORAL IMMUNE RESPONSES TO VZV1*

SHINGRIX is the first and only shingles vaccine to combine two components, a non-live antigen with an Adjuvant System.1,2*

SHINGRIX Mechanism of Action SHINGRIX Mechanism of Action

VZV = varicella zoster virus.
* Clinical significance has not been established.

Learn more about the design of SHINGRIX

Discover the components and the mechanism of action of SHINGRIX.

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Meet the patients that are eligible to receive SHINGRIX

Nearly everyone ≥50 years old should be protected against shingles.3

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What was shown to be the dominant driver of shingles?

Learn about age-related decline in immunity.4

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The safety profile of SHINGRIX in adults ≥50 years was extensively studied in two large phase III clinical trials (ZOE-50 and ZOE-70)1-3

Learn more about the safety profile of SHINGRIX.1

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References:

  1. SHINGRIX Product Monograph. GlaxoSmithKline Inc., November 15, 2022.
  2. Lal H et al. Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. N Engl J Med 2015;372(22):2087-2096.
  3. Public Health Agency of Canada. An Advisory Committee Statement (ACS), National Advisory Committee on Immunization (NACI) – Updated Recommendations on the Use of Herpes Zoster Vaccines. Ottawa, Ontario: Public Health Agency of Canada; June 2018. Available at: https://www.canada.ca/en/services/health/publications/healthy-living/updated-recommendations-use-herpes-zoster-vaccines.html. Accessed November 30, 2022.
  4. Harpaz R, Ortega-Sanchez IR, Seward JF; Advisory Committee on Immunization Practices (ACIP), Centers for Disease Control and Prevention (CDC). Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2008;57(RR-5):1-30.

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