Indications and clinical use:
- Indicated for prevention of herpes zoster (HZ, or shingles) in adults 50 years of age or older
Contraindications:
- Patients with a known hypersensitivity to the active substance or to any component of the vaccine
Most serious warnings and precautions:
- Administration: Do not administer the vaccine intravascularly, intradermally or subcutaneously
Other relevant warnings and precautions:
- A protective immune response may not be elicited in all vaccinees
- Not for prevention of primary varicella infection or treatment of HZ or postherpetic neuralgia
- Postpone in those with acute severe febrile illness
- Use with caution in those with thrombocytopenia or any coagulation disorder
- Syncope following or before any vaccination as a psychogenic response
- Fever and shivering were more frequent when the 23-valent pneumococcal polysaccharide (PPV23) vaccine was co-administered with SHINGRIX
- Use in special populations such as pregnant or nursing women or pediatrics (<18 years of age) has not been established
- Limited data in immunocompromised adults 50 years of age or older