FEV1, forced expiratory volume in one second;
Cardiovascular events, such as cardiac arrhythmias, may be seen after the administration of muscarinic recepter antagonists and sympatho-mimetic agents, including umeclidinium/vilanterol. Therefore, Anoro Ellipta should be used with caution in patients with severe cardiovascular disease. 5
Details of the blinding process for all tiotropium comparatory studies discusses in this web page can be found on page 474 in Decramer M et al. Lancet Respir Med 2014; 2:472-486,3 and page 2190 in Maleki-Yazdi M et al. Adv Ther 2016; 33:2188-21991
*Trough FEV1 improved by 252mL for Anoro (n=230¶) vs. 107mL for tiotropium (n=216¶) 12
**Reduced by 2.0 puffs/day for Anoro (n=776) vs. 1.4 puffs/day for tiotropium (n=764) 1
¶Number of subjects with analysable data at Day 169 based on a pooled post hoc subgroup analysis of three studies 12
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