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BEXSERO dosing and administration

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Recommended dosing schedule for BEXSERO 1

Recommended dosing schedule 1

The table shows the Recommended dosing schedule for BEXSERO. For a detailed description of the table, please contact GSK customer service at 1-800-387-7374.

* The initial course can also be given as 3 injections with ≥1 month interval between the primary doses. A booster dose should be given in the 2nd year of life after an interval of ≥6 months from the last injection of the initial course. 
† The need for, and timing of further doses has not yet been determined.

BEXSERO should be given by deep intramuscular injection, preferably in the anterolateral aspect of the thigh in infants or in the deltoid muscle region of the upper arm in older subjects. The vaccine must not be mixed with other vaccines or medicinal products in the same syringe.

When given concomitantly with other vaccines, BEXSERO should be administered at a different injection site. BEXSERO must not be mixed with other medicinal products or other vaccines in the same syringe.

Sufficient data are not available on the safety and effectiveness of using BEXSERO and other meningococcal group B vaccines interchangeably to complete the vaccination series. Therefore, it is recommended that subjects who receive a first dose of BEXSERO complete the vaccination course with BEXSERO.

Your patients can visit the consumer website BEXSERO.ca for a handy dose planner. They can also sign up for dose reminders via text or email.

For children, adolescents and adults aged 2 through 25 years, the second dose should be administered not less than one month after the first dose; a booster should be considered in individuals at continued risk of exposure to meningococcal disease, based on guideline recommendations.

BEXSERO provides flexible dosing options intended to fit routine vaccination visits and can be co-administered with other vaccines 1

BEXSERO can be given concomitantly with any of the following vaccine antigens (either as monovalent or as combination vaccines):

  • diphtheria
  • tetanus
  • acellular pertussis
  • H. influenzae type b
  • inactivated poliomyelitis
  • hepatitis B
  • heptavalent pneumococcal conjugate
  • measles
  • mumps
  • rubella
  • varicella
  • meningococcal groups A, C, W, Y conjugate

As higher percentages of subjects reported systemic reactions, including fever, change in eating habits, tenderness at the injection site and irritability, following BEXSERO given concomitantly with routine vaccines than after BEXSERO alone, separate vaccinations can be considered when possible. Prophylactic use of acetaminophen reduces the incidence and severity of fever without affecting the immunogenicity of either BEXSERO or most antigens of routine vaccines. The effect of antipyretics other than acetaminophen on the immune response has not been studied.

Concomitant administration of BEXSERO with vaccines other than those mentioned above has not been studied.

BEXSERO should be given by deep intramuscular injection, preferably in the anterolateral aspect of the thigh in infants or in the deltoid muscle region of the upper arm in older subjects.

When given concomitantly with other vaccines, BEXSERO should be administered at a different injection site. BEXSERO must not be mixed with other medicinal products or other vaccines in the same syringe.

Reference:

  1. BEXSERO Product Monograph. November 9, 2023.

This page is for Healthcare Professionals only. If you are not a Healthcare Professional, please visit our consumer website BEXSERO.ca.

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