BEXSERO can be given concomitantly with any of the following vaccine antigens (either as monovalent or as combination vaccines):
As higher percentages of subjects reported systemic reactions, including fever, change in eating habits, tenderness at the injection site and irritability, following BEXSERO given concomitantly with routine vaccines than after BEXSERO alone, separate vaccinations can be considered when possible. Prophylactic use of acetaminophen reduces the incidence and severity of fever without affecting the immunogenicity of either BEXSERO or most antigens of routine vaccines. The effect of antipyretics other than acetaminophen on the immune response has not been studied.
Concomitant administration of BEXSERO with vaccines other than those mentioned above has not been studied.
BEXSERO should be given by deep intramuscular injection, preferably in the anterolateral aspect of the thigh in infants or in the deltoid muscle region of the upper arm in older subjects.
When given concomitantly with other vaccines, BEXSERO should be administered at a different injection site. BEXSERO must not be mixed with other medicinal products or other vaccines in the same syringe.