You are now leaving GSK’s website

You are now leaving a GSK Website. By clicking this link, you will be taken to a website that is not owned or controlled by GSK, and GSK is not responsible for the content provided on that site

Continue

Go back

Popup

Efficacy

Ventolin Inhaled Salbutamol

Fast onset

Fast onset of action within 5 minutes, peak bronchodilation within 10 minutes37

Ventolin Packshots

Salbutamol vs formoterol

comparing-molecules

2x = two times
Comparative Pharmacology of Salmeterol and Formoterol and their Interaction with Salbutamol in Healthy Volunteers I M. W Blom and De K. Sommers
Department of Pharmacology, University of Pretoria, Pretoria, South Africa

Salbutamol vs lpratropium

2x = two times
The current role of ipratropium bromide in an acute exacerbation of asthma Colin VE Powell 11and Noel E Cranswick 7

Ventolin vs Xanthines

ventolin_packshot

Salbutamol produced significantly greater bronchodilation than theophylline for the initial 30 min1

Immedlate bronchodllator actlon occurs upon admlnlstratlon of |nhaled Salbutamol - Highly desirable for the effective relief of acute asthma symptoms1

Minimal Systemic effects resulting from stimulation of B-adrenoceptors in the heart, peripheral vasculature and skeletal muscle, due to the low drug systemic circulation after pressurized aerosol inhalation1

Xanthines in view of GINA Guidelines 2020

caution

Sustained-release of theophylline has weak efficacy in Asthma 2 
Theophylline side-effects are common and may be life—threatening at higher doses2
Theophylline is not recommended for use in children due to lack of efficacy and safety data2 
In adults with severe asthma exacerbations, add-on treatment with aminophylline does not improve outcomes vs SABA alone2

*SABA - Short-acting β2 agonist

Ventoloin_Respirator

Go to Close Top

Ventolin Oral Salbutamol

According to The American Society for Pharmacology & Experimental Therapeutics regarding Bronchodilators:5

SALBUTAMOL is considered the drug of choice as relief medication for symptoms of Bronchospasm due to its RAPID ONSET OF ACTION.

Oral Ventolin (Salbutamol) was effective in inducing bronchodilation in children with wheeze.6

Oral Ventolin (Salbutamol) effectively improved wheeze in 83% children after 5 days of therapy.6
 

who_image-new


WHO recommends use of oral salbutamol due to improved compliance and time & resource constraint to educate patients on inhaler techniques4

Ventolin Expectorant

Ventolin Expectorant is designed to relieve respiratory obstruction & improve pulmonary ventilation.8

According to the Journal of COPD Foundation:

Guaiphenesin is thought to increase hydration and decrease viscosity of mucus leading to: improved clearance of accumulated secretions from the upper and lower airway.9

According to American Family Physician,

Guaiphenesin is the only expectorant that has been considered effective by the U.S. Food and Drug Administration.10


References:

  1. MARLIN G.E and B.J.S. HARTNETT, Comparison Of Oral Theophylline and Salbutamol By Inhalation In Asthmatic Patients, Br. J. clin. Pharmac. (1976), 3, 591-594.
  2. GINA. Global strategy for asthma  management and prevention, 2020. Availble at: www.ginaasthma.org.
  3. Ventolin Respiratory Solution Datasheet. Version Number: GDS25/IPI09. Date of Issue: 14 April 2014.
  4. Simon Craig et al, it is time to stop prescribing oral salbutamol The Royal Australian College of General Practitioners 2016, AFP VOL.45,NO.4 APRIL 2016.
  5. Mario Cazzola, Clive P. Page, Luigino Calzetta, and M. Gabriella Matera,Pharmacology and Therapeutics of Bronchodilators Mario , Pharmacol Rev 64:450–504, 2012, Vol 64.
  6. T Hazir et al, Comparison of clinical outcome with oral & inhaled bronchodilators in the management of wheezy children aged 1-59 months in the community: A randomized trial in Pakistan.INT J TUBERC LUNG DIS 8(): 1308-1314 2004.
  7. Ventolin Evohaler Datasheet. Version Number: GDS24/IPI08. Date of Issue: 21st May 2013.
  8. Ventolin Expectorant Datasheet .Version number: 16. Date of Issue : 05 February 2014.
  9. Jill A;Journal of the COPD foundation;2019;6;341-349.
  10. Miller KE; Effectiveness of Guaiphenesin in the treatment of COugh:;Am Fam Physician;2004;70;384-386.
  11. Sanders M. Prim Care Respir J 2007;16:71–81.

 

Adverse Events must be reported. For products related to GSK Pakistan, please report adverse events via email at pk_pharmasafety@gsk.com or call us at +92 (21) 111 475 725 - Ext: 7 & 8

Full prescribing information is available on request.
GlaxoSmithKline Pakistan Limited
35 - Dockyard Road, West Wharf, Karachi - 74000.
Ventolin and Evohaler are trademarks of GlaxoSmithKline group of companies
GlaxoSmithKline Pakistan Limited is a member of GlaxoSmithKline group of companies.
© 2021 GlaxoSmithKline Pakistan Limited