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Middle-aged woman has blown out the candles on her 50th birthday cake, producing red smoke.

Recommend the shingles vaccine formulated to address age-related decline in immunity to varicella-zoster virus.1-3

SHINGRIX demonstrated >90% efficacy against shingles in all age groups 50 years of age and older based on pooled data from two large, phase 3 randomised controlled trials.1,4,5

What is SHINGRIX?

SHINGRIX is indicated for prevention of herpes zoster (HZ) and post-herpetic neuralgia (PHN), in:

  • adults 50 years of age or older;
  • adults 18 years of age or older at increased risk of HZ.1

Use of SHINGRIX should be in accordance with official recommendations.1

SHINGRIX is contraindicated to anyone with hypersensitivity to the active substances or to any of the excipients. Please refer to the prescribing information for further details.

Learn more about SHINGRIX

Red virus icon

Addressing age-related decline in immunity.

SHINGRIX – specifically formulated to help address age-related decline in varicella zoster virus specific immunity in adults 50 years of age and older.1-5

UNDERSTAND THE SCIENTIFIC RATIONALE

Red patient icon, 4 patient figures, 1 of the 4 coloured grey

Who can benefit from SHINGRIX?

There is a 1 in 3 lifetime risk of developing shingles.6,7 Age-related decline in immunity puts patients 50 years of age and older at an increased risk of developing shingles.8,9

View Patient Profiles

Red circular icon, showing greater than 90% efficacy against herpes zoster

How efficacious is SHINGRIX?

SHINGRIX demonstrated >90 % efficacy against shingles in adults 50 years of age and older based on pooled data from two large, phase 3 randomised controlled trials.1,4,5

Review Efficacy Data

NA

SHINGRIX has a clinically acceptable safety and tolerability profile.1-5

The majority of solicited local adverse reactions were mild to moderate based on data from two large, phase 3 clinical studies.4,5

Review Safety Information

References

  1. Shingrix, Summary of Product Characteristics (SPC), available on https://www.medicines.ie/medicines/shingrix-powder-and-suspension-for-suspension-for-injection-herpes-zoster-vaccine-recombinant-adjuvanted--35192/spc. Last Accessed: January 2022
  2. Chlibek R, Smetana J, Pauksens K, Rombo L, Van den Hoek JA, Richardus JH, et al. Safety and immunogenicity of three different formulations of an adjuvanted varicella- zoster virus subunit candidate vaccine in older adults: a phase II, randomized, controlled study. Vaccine. 2014 Mar;32 (15):1745-53.
  3. Leroux-Roels I, Leroux-Roels G, Clement F, Vandepapelière P, Vassilev V, Ledent E, Heineman TC. A phase 1 /2 clinical trial evaluating safety and immunogenicity of a varicella zoster glycoprotein e subunit vaccine candidate in young and older adults. J Infect Dis. 2012 Oct;206 (8):1280-90.
  4. Lal H, Cunningham AL, Godeaux O, Chlibek R, Diez-Domingo J, Hwang S-J, et al. Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. N Engl J Med. 2015 May;372 (22):2087-96.
  5. Cunningham AL, Lal H, Kovac M, Chlibek R, Hwang S-J, Diez-Domingo J, et al. Efficacy of the herpes zoster subunit vaccine in adults 70 years of age or older. N Engl J Med. 2016 Sep;375 (11):1019-32.
  6. Harpaz R, et al. MMWR Recomm Rep. 2008 June;57(RR-5):1-30. 2. Zerboni L, et al. Nat Rev Microbiol. 2014 Mar;12 (3):197-210.
  7. Bollaerts K et al. A systematic review of varicella seroprevaience in European countries before universal childhood immunization: deriving incidence from seroprevaience data. Epidemiol. Infect. (2017), 145, 2666-2677.
  8. Kimberlin DW, Whitley RJ. Varicella-zoster vaccine for the prevention of herpes zoster. N Engl J Med. 2007 Mar;356 (13):1338-43.
  9. Crooke, S.N., et al. Immun Ageing. 2019 Sep 13; 16:25.

Adverse events should be reported directly to the Health Products Regulatory Authority (HPRA) on their website: www.hpra.ie . Adverse events should also be reported to GlaxoSmithKline on 1800 244 255.

SHINGRIX is owned by or licensed to the GSK group of companies.
© 2022 GSK group of companies or its licensor.
Trade marks are owned by or licensed to the GSK group of companies.

Date of Preparation: January 2023 PM-IE-SGX-WCNT-220002