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How efficacious is SHINGRIX?
SHINGRIX demonstrated >90% efficacy against shingles in adults 50 years of age and older based on pooled data from two large, phase 3 randomised controlled trials.1,3,4
Meet Jennifer*
She's healthy, and still at risk of shingles**
Who is Jennifer?
Married, self-employed, takes care of her children and is very active in her running club.
Lifestyle:
- Healthy eater
- Daily walker
- Frequent runner
Medical History:
No current medical issues
How would shingles affect her life?
She won't be able to both manage her business and take care of her children.
Recommendation Opportunity:
When scheduling a flu vaccination
*Not an actual patient
**The risk of shingles increases with age, with a steep increase occurring at age 50.7
Meet Karl*
Takes care of others, even though he has a higher risk of shingles.**
Who is Karl?
Friendly dog owner and beloved neighbour who enjoys playing with his dogs and helping around the neighbourhood.
Lifestyle:
- Too busy to exercise regularly
- Unhealthy eating habits
Medical History:
COPD
How would shingles affect his life?
He would find it difficult to do routine tasks, and an HZ episode may exacerbate his COPD symptoms.^
Recommendation Opportunity:
- When in for patient review
- When seeking a repeat prescription
- When scheduling a flu vaccination
*Not an actual patient
**The risk of shingles increases with age, with a steep increase occurring at age 50.7 COPD patients have a higher risk of herpes zoster RR 1.41 (95% CI: 1.28-1.55)8
^Survey of 735 COPD patients, of whom 192 reported previous HZ . 49 (25.5%) reported increased COPD symptoms during HZ episodes.9
Meet Susan*
As she adjusts to life as a caregiver, she needs protection from shingles.**
Who is Susan?
Married mother of two college graduates, caretaker of her ailing mother, and a non-profit organisation co-founder.
Lifestyle:
- Eats well
- Exercises frequently
Medical History:
Type 2 diabetes that is well controlled
How would shingles affect her life?
Shingles would disrupt the care she provides to her mother and may increase her HbA1c levels.10^
Recommendation Opportunity:
- When in for medical review
- When seeking repeat prescription
- When in for seasonal vaccinations
*Not an actual patient
**The risk of shingles increases with age, with a steep increase occurring at age 50.7
^Retrospective cohort of 2,289,485 subjects >50 years from Spain, 397,940 of whom had diabetes. 24% of patients with well-controlled diabetes (HbA1c ≤ 6.5%) before the shingles diagnosis had increased HbA1c levels after the shingles diagnosis (HbA1c > 6.5%).10
Meet
Richard*
As he's getting older, he should prioritise his shingles risk.**
Who is Richard?
Married, father, doctor and teacher. While he could have retired by now, his students and profession are very important to him.
Lifestyle:
- Isn't exercising enough
- Has decreased mobility
Medical History:
Cardiovascular (CV) disease
How would shingles affect his life?
Shingles would remove him from his true passion - teaching, and may increase his risk of PHN.7
Recommendation Opportunity:
- When in for medical review
- When seeking a repeat prescription
- When in for seasonal vaccinations
*Not an actual patient
**The risk of shingles increases with age, with a steep increase occurring at age 50 and continuing to increase at age 70.7
More information on SHINGRIX
References
- Shingrix, Summary of Product Characteristics (SPC), available on https://www.medicines.ie/medicines/shingrix-powder-and-suspension-for-suspension-for-injection-herpes-zoster-vaccine-recombinant-adjuvanted--35192/spc. Last Accessed: May 2023
- Kimberlin DW, Whitley RJ. Varicella-zoster vaccine for the prevention of herpes zoster. N Engl J Med. 2007 Mar;356 (13):1338-43.
- Lal H, Cunningham AL, Godeaux O, Chlibek R, Diez-Domingo J, Hwang S-J, et al. Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. N Engl J Med. 2015 May;372 (22):2087-96.
- Cunningham AL, Lal H, Kovac M, Chlibek R, Hwang S-J, Diez-Domingo J, et al. Efficacy of the herpes zoster subunit vaccine in adults 70 years of age or older. N Engl J Med. 2016 Sep;375 (11):1019-32.
- Chlibek R, Smetana J, Pauksens K, Rombo L, Van den Hoek JA, Richardus JH, et al. Safety and immunogenicity of three different formulations of an adjuvanted varicella-zoster virus subunit candidate vaccine in older adults: a phase II, randomized, controlled study. Vaccine. 2014 Mar;32 (15):1745-53.
- Leroux-Roels I, Leroux-Roels G, Clement F, Vandepapelière P, Vassilev V, Ledent E, Heineman TC. A phase 1 /2 clinical trial evaluating safety and immunogenicity of a varicella zoster glycoprotein e subunit vaccine candidate in young and older adults. J Infect Dis. 2012 Oct;206 (8):1280-90.
- Centers for Disease Control and Prevention. Shingles Vaccination. Reviewed May 24, 2022. Accessed March 2023. https://www.cdc.gov/vaccines/vpd/shingles/public/shingrix/index.html
- Marra F, Parhar K, Huang, B, et al. Risk Factors for Herpes Zoster Infection: A Meta-Analysis. Open Forum Infect Dis. 2020;7(1):ofaa005
- Yawn; Knowledge and Attitudes Concerning Herpes Zoster among People with COPD: An Interventional Survey StudyYP; Vaccine;2022;10;1-13
- Muños-Quiles C, Lópes-Lacort M, Ampudia-Blasco FJ, et al. Risk and impact of herpes zoster on patients with diabetes: a population-based study, 2009-2014. Human Vacc Immunother. 2017;13(11):2606-11. doi.org/10.1080/21645515.2017.1368600
Adverse events should be reported directly to the Health Products Regulatory Authority (HPRA) on their website: www.hpra.ie. Adverse events should also be reported to GlaxoSmithKline on 1800 244 255.
SHINGRIX is owned by or licensed to the GSK group of companies. © 2023 GSK group of companies or its licensor.
Trade marks are owned by or licensed to the GSK group of companies.
PM-IE-SGX-WCNT-210006 | Date of Preparation: May 2023
