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RUMBA Efficacy

THE FIRST HEAD-TO-HEAD CLINICAL TRIAL vs BIC/FTC/TAF

97% (79/81) and 98% (39/40) of participants in the DOVATO and BIC/FTC/TAF arms respectively had plasma HIV-1 RNA <50 copies/mL at Week 48¹
Viral reservoir (primary endpoint): Early data show no difference in the HIV-1 reservoir dynamics between DOVATO and BIC/FTC/TAF¹

Switch to DOVATO from a 3-drug regimen did not increase the total or intact HIV-1 viral reservoir after 48 weeks compared with a switch from BIC/FTC/TAF¹

Adapted from Vandekerckhove et al, 2022.¹

RUMBA Study Design

MORE THAN 130 VIRLOGICALLY SUPPRESSED PATIENTS RANDOMISED TO SWITCH TO DOVATO OR STAY ON BIC/FTC/TAF

Prospective, Single-Centre, Open-Label Randomised, Non-Inferiority Switch Study¹
Baseline Characteristics

PEOPLE LIVING WITH HIV SWITCHED TO DOVATO OR BIC/FTC/TAF¹

The RUMBA study is a randomised trial evaluating the efficacy of DOVATO vs BIK/FTC/TAF via viral reservoirs in virologically suppressed people living with HIV

Adapted from Vandekerckhove et al, 2022. ¹

References:

Vandekerckhove L, Trypsteen W, Bloome E, et al. Impact of switch towards 3TC/dolutegravir on the intact and total HIV-1 viral reservoir in the Rumba study. Presented at: HIV Glasgow 2022; October 23-26, 2022; Glasgow, UK. Slides MO42.

Dovato is a registered trade mark of the ViiV Healthcare group of companies or its licensor.

Adverse events should be reported directly to the Health Products Regulatory Authority (HPRA) on their website: www.hpra.ie. Adverse events should also be reported to GlaxoSmithKline on 1800 244 255.

Date of Preparation: March 2024
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