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VZVに初めて感染すると水痘を発症し、その後、VZVは知覚神経節に潜伏します。加齢に伴い細胞性免疫が低下すると、VZVが再活性化し、帯状疱疹を発症します。50歳以上のVZV抗体保有率は100％であったとの報告もあり、50歳以上のほぼすべての人は帯状疱疹の発症リスクがあるといえます。
加齢に伴う細胞性免疫の低下とVZVの再活性化
*2001～2005年に国立感染症研究所により収集された全国の健康な日本人（0～82歳）の血清標本828検体の水痘帯状疱疹ウイルスIgG型抗体を測定。
PM-JP-SGX-WCNT-190002 2023.11
