- In every new line of therapy, approximately 50% of patients die, or are lost to follow-up2
- As the disease progresses and becomes resistant to treatment, there are fewer treatment options resulting in poor outcomes for triple class refractory patients, who have less than 12 months overall survival.3,4
- BCMA is expressed in 100% of multiple myeloma patients, making it an ideal target5,6
For GB healthcare professionals only.*
Why do we need treatment options in multiple myeloma?
BLENREP is indicated as monotherapy for the treatment of multiple myeloma in adult patients, who have received at least four prior therapies and whose disease is refractory to at least one proteasome inhibitor, one immunomodulatory agent, and an anti-CD38 monoclonal antibody, and who have demonstrated disease progression on the last therapy.1
The DREAMM-2 clinical trial studied BLENREP as a single agent in triple-class refractory patients with multiple myeloma (n=97; 40-month follow up analysis)*7,8
*Median seven prior lines of therapy in DREAMM-2 patient population. BLENREP is indicated for patients who have received at least four prior lines of therapy.1,8
DREAMM-2 clinical trial
Learn more about the pivotal DREAMM-2 clinical trial for BLENREP
Explore our range of BLENREP content
Rethink your treatment strategy with a different MoA: BLENREP is the first and only licensed B-cell maturation antigen (BCMA) targeted antibody drug conjugate treatment for triple-class refractory multiple myeloma patients. 1
The evolving treatment landscape and unmet needs in relapsed/refractory multiple myeloma (RRMM)Dr Karthik Ramasamy discusses the current standard of care in triple refractory multiple myeloma, and the rationale for targeting BCMA.
BLENREP in triple refractory RRMM: A clinical data reviewDr Rakesh Popat presents the DREAMM-2 study, including efficacy results, safety data, and how eye-related side effects were managed.
Responses to BLENREP were deep, durable and fast in a heavily pre-treated triple-class refractory population1,8
- 32% response rate (n=31/97; 97.5% confidence interval (CI): 21.7-43.6) for patients who have received a median of seven prior lines of therapy - 58% (n=18/31) of patients whose disease responded achieved a very good partial response (VGPR) or better response8
BLENREP has a generally well tolerate and manageable safety profile1
- Side effects were generally manageable through supportive care and dose modifications, with no requirement for steroids as premedication1
BLENREP offers a practical treatment option for a broad range of patients who need BCMA-targeted therapy1
- Outpatient administration, with an intravenous infusion over a minimum of 30 minutes, once every 3 weeks1
- No steroids, like dexamethasone, are required prior to starting treatment with BLENREP1
UNDERSTAND BLENREP DOSING HERE
Please refer to the SmPC for a full list of adverse events and for the dosing schedule.
*BLENREP is not commercially available in Northern Ireland.
BCMA, B-cell maturation antigen; CI, confidence interval; DREAMM-2, DRiving Excellence in Approaches to Multiple Myeloma 2; MoA, mechanism of action; NR, not reached; RRMM, relapsed/refractory multiple myeloma; VGPR, very good partial response.
- BLENREP Summary of Product Characteristics.
- Fonseca R, et al. Characterization of Frontline Treatment Patterns and Attrition Rates According to Subsequent Lines of Therapy in Non-Transplant Patients with Newly Diagnosed Multiple Myeloma. Poster presented at the 60th American Society of Hematology (ASH) Annual Meeting & Exposition; December 1–4, 2018; San Diego, California. Abstract #3291.
- Mikhael J. Clin Lymphoma Myeloma Leuk. 2020;20(1):1–7.
- Gandhi UH et al. Leukemia. 2019;33:2266-2275.
- Tai YT, Anderson KC. Immunotherapy. 2015;7(11):1187–1199.
- Farooq AV, et al. Ophthalmol Ther. 2020;9(4):889–911.
- Lonial S, et al. Cancer. 2021;127(22):4198–4212.
- Nooka S, et al. Presented at the 64th American Society of Hematology Annual Meeting and Exposition, New Orleans, USA, December 10-13, 2022. Poster 3246.
▼This medicine is subject to additional monitoring. This will allow quick identification of new safety information.
Adverse events should be reported. Reporting forms and information can be found at https://yellowcard.mhra.gov.uk/ or search for MHRA Yellowcard in the Google Play or Apple App store. Adverse events should also be reported to GlaxoSmithKline on 0800 221 441.
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May 2023 | PM-GB-BLM-WCNT-220010 (V3.0)