Proven and tested in eosinophilic disease3
Help your patients with recurrent nasal polyps today with Nucala1
Nucala is indicated as an add-on therapy with intranasal corticosteroids for the treatment of adult patients with severe CRSwNP (Chronic Rhinosinusitis with Nasal Polyps) for whom therapy with systemic corticosteroids and/or surgery do not provide adequate disease control.3
In the SYNAPSE study, all primary and secondary endpoints were met with statistical significance.1
SELECTED SAFETY INFORMATION
Warnings/Precautions: Should not be used to treat acute asthma exacerbations. Patients should be instructed to seek medical advice if their asthma remains uncontrolled or worsens after starting treatment. Abrupt discontinuation of corticosteroids after initiation of mepolizumab treatment is not recommended.
Allergic reactions: Acute and delayed systemic reactions, including hypersensitivity reactions, have occurred following administration of mepolizumab. Patients should be instructed to seek medical attention immediately if allergic reactions occur. In the event of a hypersensitivity reaction, appropriate treatment as clinically indicated should be initiated.
Parasitic infections: Pre-existing helminth infections should be treated before starting therapy. If patients become infected whilst receiving treatment with mepolizumab and do not respond to anti-helminth treatment, temporary discontinuation of therapy should be considered.
Organ-threatening or life-threatening manifestations of EGPA and HES: Has not been studied.
Adverse reactions: In clinical studies in patients with severe refractory eosinophilic asthma and EGPA, headache, injection site reactions and back pain were the most commonly reported adverse reactions during treatment. In patients with CRSwNP: Headache and back pain. In patients with HES: Headache, urinary tract infection, injection site reactions and pyrexia.
Nucala is a once-monthly biologic with a fixed-dose treatment for your patients with nasal polyps
The recommended dose of mepolizumab is 100 mg administered SC once every 4 weeks.3
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**SOC defined as daily mometasone furoate nasal spray in addition to saline nasal irrigations and courses of systemic corticosteroids and/or antibiotics as required.1,2
CI, confidence interval; CRSwNP, chronic rhinosinusitis with nasal polyps; MOA, mode of action; HR, hazard ratio; IL, interleukin; LS, least squares; SC, subcutaneous; SNOT-22, sino-nasal outcome test (22-item); SOC, standard of care; VAS, visual analogue scale.
References
- Han JK et al. Lancet Respir Med.2021;9:1141-1153
- Han JK et al. Lancet Respir Med.2021;9:1141-1153 (Supplementary)
- Nucala preparatomtale
Nucala is a trademark of the GSK group of companies
PM-NO-MPL-WCNT-230002 November 2024