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Safety

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Most common adverse reactions

In TIVICAY (dolutegravir) Phase IIb and Phase III clinical studies the most common* treatment emergent adverse reactions were the following:1

Tivicay adverse reactions

*Definitions of frequencies: very common ≥ 1/10, common ≥1/100 to <1/10

Drug-drug interactions

TIVICAY has few significant interactions with commonly used medications.1-5

The table below is a useful guide to dosing TIVICAY concomitantly with other medications your patients may be taking.*

Tivicay drug-drug interactions

*The table is not exhaustive.
 §In paediatric patients the weight-based once daily dose should be administered twice daily if used in combination with these medications.1

 EFV: efavirenz
 NVP: nevirapine
 TPV/r: tipranavir/ritonavir

For a more comprehensive list of interactions, please see the HIV DDI database of University of Liverpool.

Contraindications

TIVICAY and dofetilide coadministration is contraindicated due to potential life-threatening toxicity caused by high dofetilide concentration.1

For further information on Tivicay safety, please see the Summary of Product Characteristics.

References:

  1. TIVICAY preparatomtale.
  2. Fantauzzi A, Turriziani O, Mezzaroma I. Potential benefit of dolutegravir once daily: efficacy and safety. HIV/AIDS (Auckl). 2013;5:29-40. doi: 10.2147/HIV.S27765
  3. Teixeira R, Nascimento Y, Crespo D. Safety aspects of protease inhibitors for chronic hepatitis C: adverse events and drug-to-drug interactions. Braz J Infect Dis. 2013;17(2):194-204.
  4. Patel P, Song I, Borland J, et al. Pharmacokinetics of the HIV integrase inhibitor S/GSK1349572 co-administered with acid- reducing agents and multivitamins in healthy volunteers. J Antimicrob Chemother. 2011;66(7):1567-1572.
  5. Kandel CE, Walmsley S. Dolutegravir - a review of the pharmacology, efficacy, and safety in the treatment of HIV. Drug Design, Development and Therapy. 2015:9 3547-3555. doi: 10.2147/DDDT.S84850

TIVICAY trademark is owned by or licensed to the ViiV Healthcare group of companies.