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Pick section Severe Eosinophilic Asthma (SEA)

Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)

Severe Eosinophilic Asthma (SEA)

SEA - Dosing & administration

On this page

At home and in hospital dosing administration

How to use Nucala

At home and in hospital dosing & administration

Nucala is an asthma biologic with a fixed dose for patients aged 12 years and older (100 mg once every 4 weeks) and children from 6 to 11 years old (40 mg once every 4 weeks).¹

Nucala is indicated as an add-on treatment for severe refractory eosinophilic asthma in adults, adolescents and children aged 6 years and older.¹

Pre-filled pen

AT HOME
PRE-FILLED PEN

Pre-filled syringe

IN HOSPITAL
PRE-FILLED SYRINGE

Lyophilised powder

IN HOSPITAL
POWDER FOR SOLUTION

Nucala may be administered by a caregiver if a healthcare professional determines that it is appropriate, and the caregiver is trained in injection techniques.

Dosing and Administration¹

	Patients aged 6 to 11 years	Patients aged ≥12 years
Form	Lyophilised powder Pre-filled syringe	Pre-filled pen Pre-filled syringe Lyophilised powder
Administration	40 mg subcutaneously every 4 weeks	100 mg subcutaneously every 4 weeks
Injection site	Lyophilised powder by healthcare professional: abdomen, thigh or upper arm Healthcare professional or caregiver*: abdomen, thigh or upper arm	Lyophilised powder by healthcare professional: abdomen, thigh or upper arm Self-administration: abdomen or thigh (for pre-filled formulations only) By caregiver: abdomen, thigh or upper arm (for pre-filled formulations only)

*Nucala may be administered by a caregiver (for pre-filled syringe only) if a healthcare professional determines that it is appropriate, and the caregiver is trained in injection techniques.
**Nucala may be self-administered by the patient or administered by a caregiver if their healthcare professional determines that it is appropriate, and the patient or caregiver are trained in injection techniques.

Biologic licensed to treat SEA in children 6-11 years old¹

Nucala in the paediatric population

See the paediatric safety profile

SELECTED SAFETY INFORMATION

Warnings/Precautions: Should not be used to treat acute asthma exacerbations. Patients should be instructed to seek medical advice if their asthma remains uncontrolled or worsens after starting treatment. Abrupt discontinuation of corticosteroids after initiation of mepolizumab treatment is not recommended.

Allergic reactions: Acute and delayed systemic reactions, including hypersensitivity reactions, have occurred following administration of mepolizumab. Patients should be instructed to seek medical attention immediately if allergic reactions occur. In the event of a hypersensitivity reaction, appropriate treatment as clinically indicated should be initiated.

Parasitic infections: Pre-existing helminth infections should be treated before starting therapy. If patients become infected whilst receiving treatment with mepolizumab and do not respond to anti-helminth treatment, temporary discontinuation of therapy should be considered.

Organ-threatening or life-threatening manifestations of EGPA and HES: Has not been studied

Adverse reactions: In clinical studies in patients with severe refractory eosinophilic asthma and EGPA, headache, injection site reactions and back pain were the most commonly reported adverse reactions during treatment. In patients with CRSwNP: Headache and back pain. In patients with HES: Headache, urinary tract infection, injection site reactions and pyrexia.